Dr. Yuan’s research focuses on the etiologic and protective roles of environmental exposures and genetic factors, and their interaction in the development of cancers. He is Principal Investigator (PI) of both the Shanghai Cohort Study and the Singapore Chinese Health Study - two population-based prospective cohort studies of more than 80,000 middle-aged men and women with available biospecimens collected at baseline and under surveillance for more than 25 years. He is also the current PI of the Pittsburgh Lung Screening Study that has collected repeated annual blood samples and biannual low-dose CT scans on a cohort of 3600 smokers at high risk for lung cancer. The ultimate goal of Dr. Yuan’s research is to discover and validate biomarkers that can characterize individuals at high risk for cancer and early detection of cancer, and to identify natural agents for primary cancer prevention. Dr. Yuan is passionate about teaching and training on graduate students and post-doctoral fellows. He is the Director of the Translational Research Training in Cancer Etiology and Prevention Program, a multi-disciplinary cross-college training program at University of Pittsburgh Cancer Institute and the Department of Epidemiology, and is PI of the National Cancer Institute (NCI) funded T32 training grant.
1983 | Fudan University Shanghai Medical College | MD, Medicine
1986 | Fudan University School of Public Health | MPH, Public Health/Epidemiology
1996 | University of Southern California Keck School of Medicine | PhD, Epidemiology
- Yuan J-M, Grouls M, Carmella SG, Wang R, Heskin A, Jiang Y, Tan YT, Adams-Haduch J, Gao YT, Hecht SS: Prediagnostic levels of urinary 8-epi-prostaglandin F2alpha and prostaglandin E2 metabolite, biomarkers of oxidative damage and inflammation, and risk of hepatocellular carcinoma. Carcinogenesis 2019;40:989-997. PMC7967701
- Yuan J-M, Wang Y, Wang R, Luu HN, Adams-Haduch J, Koh WP, Gao YT, Behari J, Lotze MT. Serum IL27 in Relation to Risk of Hepatocellular Carcinoma in Two Nested Case-Control Studies. Cancer Epidemiol Biomarkers Prev 30:388-395, 2021. PMC7867592.
- Luu HN, Behari J, Goh GB, Wang R, Jin A, Thomas CE, Clemente JC, Odegaard AO, Koh WP, Yuan J-M. Composite Score of Healthy Lifestyle Factors and Risk of Hepatocellular Carcinoma: Findings from a Prospective Cohort Study. Cancer Epidemiol Biomarkers Prev 30:380-387, 2021. PMC7867589.
- Yu YC, Luu HN, Wang R, Thomas CE, Glynn NW, Youk AO, Behari J, Yuan J-M. Serum Biomarkers of Iron Status and Risk of Hepatocellular Carcinoma Development in Patients with Nonalcoholic Fatty Liver Disease. Cancer Epidemiol Biomarkers Prev 31:230-235, 2022 Jan. PMC9204666.
- Thomas CE, Adibi JJ, Kuipers AL, Diergaarde B, Luu HN, Jin A, Koh WP, Gao YT, Adams-Haduch J, Wang R, Lokshin A, Behari J, Yuan J-M. Soluble CD137 and risk of hepatocellular carcinoma: nested case-control studies in cohorts in Shanghai and Singapore. Br J Cancer 128:2081-2088, 2023 Jun. PMC10206096.
- Stacy SL, Buchanich JM, Ma ZQ, Mair C, Robertson L, Sharma RK, Talbott EO, Yuan J-M: Maternal obesity, birth size, and risk of childhood cancer development. Am J Epidemiol 2019;188:1503-1511. PMC6670047
- Samavat H, Luu HN, Beckman KB, Jin A, Wang R, Koh WP, Yuan J-M. Leukocyte telomere length, cancer incidence and all-cause mortality among Chinese adults: Singapore Chinese Health Study. Int J Cancer 148:352-362, 2021. PMC10693991
- Paudel S, Warner BE, Wang R, Adams-Haduch J, Reznik AS, Dou J, Huang Y, Gao YT, Koh WP, Backerholm A, Yuan J-M, Shair KHY. Serologic Profiling Using an Epstein-Barr Virus Mammalian Expression Library Identifies EBNA1 IgA as a Prediagnostic Marker for Nasopharyngeal Carcinoma. Clin Cancer Res 28:5221-5230, 2022 Dec 1. PMC9722633.
- Huang JY, Larose TL, Luu HN, Wang R, Fanidi A, Alcala K, Stevens VL, Weinstein SJ, Albanes D, Caporaso NE, Purdue MP, Ziegler RG, Freedman ND, Lan Q, Prentice RL, Pettinger M, Thomson CA, Cai Q, Wu J, Blot WJ, Shu XO, Zheng W, Arslan AA, Zeleniuch-Jacquotte A, Le Marchand L, Wilkens LR, Haiman CA, Zhang X, Stampfer MJ, Han J, Giles GG, Hodge AM, Severi G, Johansson M, Grankvist K, Langhammer A, Hveem K, Xiang YB, Li HL, Gao YT, Visvanathan K, Ueland PM, Midttun O, Ulvi A, Buring JE, Lee IM, Sesso HD, Gaziano JM, Manjer J, Relton C, Koh WP, Brennan P, Johansson M, Yuan J-M. Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium. Int J Cancer 146:2394-2405, 2020. PMC6960354
- Warkentin MT, Al-Sawaihey H, Lam S, Liu G, Diergaarde B, Yuan J-M, Wilson DO, Atkar-Khattra S, Grant B, Brhane Y, Khodayari-Moez E, Murison KR, Tammemagi MC, Campbell KR, Hung RJ. Radiomics analysis to predict pulmonary nodule malignancy using machine learning approaches. Thorax 79:307-315, 2024 Mar 15. PMC10947877.
