My research has focused on the design, conduct, and analysis of multicenter clinical trials and cohort studies. Most of my work has involved the evaluation of treatments and risk factors in patients with coronary artery disease, diabetes and blood disorders and the epidemiology of cardiovascular diseases and women’s health. I am the Principal Investigator of the Coordinating Center of the Study of Women's Health Across the Nation (SWAN), a multi-racial/ethnic longitudinal cohort study designed to characterize the physiological and psychosocial changes that occur during the menopausal transition. In addition, I am the Principal Investigator of the Data Coordinating Center for the Myocardial Ischemia and Transfusion (MINT) trial, a multicenter randomized clinical trial evaluating transfusion strategies for patients with acute myocardial infarction and anemia and of the Data Coordinating Center for the Sickle Cell Disease and Cardiovascular Risk - Red cell Exchange (SCD-CARRE) trial, a randomized clinical trial evaluating the effectiveness of automated exchange transfusion for adult patients with sickle cell disease. Over the years, I have collaborated on projects involving infectious diseases including COVID-19, behavioral interventions and genetics. I teach advanced epidemiological methods.
1985 | Williams College, Williamstown, MA | Bachelor of Arts, Mathematics, cum laude
1986 | Harvard University, Cambridge, MA | Master of Arts, Statistics
1991 | University of North Carolina, Chapel Hill, NC | PhD, Statistics
2006-2012 | EPIDEM 2180: Epidemiological Methods 1
2012-2018 | EPIDEM 2187: Epidemiological Methods 2
2019-2022, 2025 | EPIDEM 2180: Fundamentals of Epidemiological Methods
2022-2024 | EPIDEM 2181: Design and Conduct of Clinical Trials
Myocardial Ischemia and Transfusion (MINT) Trial
Carson JL, Brooks MM, Hébert PC, Goodman SG, Bertolet M, Glynn SA, Chaitman BR, Simon T, Lopes RD, Goldsweig AM, DeFilippis AP, Abbott JD, Potter BJ, Carrier FM, Rao SV, Cooper HA, Ghafghazi S, Fergusson DA, Kostis WJ, Noveck H, Kim S, Tessalee M, Ducrocq G, de Barros E Silva PGM, Triulzi DJ, Alsweiler C, Menegus MA, Neary JD, Uhl L, Strom JB, Fordyce CB, Ferrari E, Silvain J, Wood FO, Daneault B, Polonsky TS, Senaratne M, Puymirat E, Bouleti C, Lattuca B, White HD, Kelsey SF, Steg PG, Alexander JH; MINT Investigators. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia. N Engl J Med. 2023 Dec 28;389(26):2446-2456. doi: 10.1056/NEJMoa2307983. Epub 2023 Nov 11. PMID: 37952133; PMCID: PMC10837004.
Portela GT, Carson JL, Swanson SA, Alexander JH, Hébert PC, Goodman SG, Steg PG, Bertolet M, Strom JB, Fergusson DA, Simon T, White HD, Cooper HA, Abbott JD, Rao SV, Chaitman BR, Fordyce CB, Lopes RD, Daneault B, Brooks MM; MINT Investigators; MINT Investigators*. Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data. Ann Intern Med. 2024 Oct 1. doi: 10.7326/M24-0571. Epub ahead of print. PMID: 39348705.
Study of Women’s Health Across the Nation (SWAN)
Derby CA, Hutchins F, Greendale GA, Matthews KA, Sternfeld B, Everson-Rose SA, Kazlauskaite R, Whitmer RA, Brooks MM. Cardiovascular risk and midlife cognitive decline in the Study of Women's Health Across the Nation. Alzheimers Dement. 2021 Aug;17(8):1342-1352. doi: 10.1002/alz.12300. Epub 2021 Mar 12. PMID: 33710770; PMCID: PMC9210934.
Hutchins F, Krafty R, El Khoudary SR, Catov J, Colvin A, Barinas-Mitchell E, Brooks MM. Gestational Weight Gain and Long-term Maternal Obesity Risk: A Multiple-Bias Analysis. Epidemiology. 2021 Mar 1;32(2):248-258. doi: 10.1097/EDE.0000000000001310. PMID: 33284167; PMCID: PMC7855686.
Matthews KA, Chang Y, Brooks MM, Crawford SL, Janssen I, Joffe H, Kravitz HM, Thurston RC, El Khoudary SR. Identifying women who share patterns of reproductive hormones, vasomotor symptoms, and sleep maintenance problems across the menopause transition: group-based multi-trajectory modeling in the Study of Women's Health Across the Nation. Menopause. 2020 Oct 5;28(2):126-134. doi: 10.1097/GME.0000000000001663. PMID: 33038144; PMCID: PMC9238015.
Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) – 4 Trials
Connors JM, Brooks MM, Sciurba FC, Krishnan JA, Bledsoe JR, Kindzelski A, Baucom AL, Kirwan BA, Eng H, Martin D, Zaharris E, Everett B, Castro L, Shapiro NL, Lin JY, Hou PC, Pepine CJ, Handberg E, Haight DO, Wilson JW, Majercik S, Fu Z, Zhong Y, Venugopal V, Beach S, Wisniewski S, Ridker PM; ACTIV-4B Investigators. Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19: The ACTIV-4B Randomized Clinical Trial. JAMA. 2021 Nov 2;326(17):1703-1712. doi: 10.1001/jama.2021.17272. PMID: 34633405; PMCID: PMC8506296.
REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators; Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, …, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26;385(9):777-789. doi: 10.1056/NEJMoa2103417. Epub 2021 Aug 4. PMID: 34351722; PMCID: PMC8362592.
ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators; Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, …, Angus DC, McArthur CJ, Webb SA, Farkouh ME, Hochman JS, Zarychanski R. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26;385(9):790-802. doi: 10.1056/NEJMoa2105911. Epub 2021 Aug 4. PMID: 34351721; PMCID: PMC8362594.
Student Mentoring/Collaboration
Zhong Y, Brooks MM, Kennedy EH, Bodnar LM, Naimi AI. Use of Machine Learning to Estimate the Per-Protocol Effect of Low-Dose Aspirin on Pregnancy Outcomes: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2022 Mar 1;5(3):e2143414. doi: 10.1001/jamanetworkopen.2021.43414. Erratum in: JAMA Netw Open. 2022 Apr 01;5(4):e229172. doi: 10.1001/jamanetworkopen.2022.9172. PMID: 35262718; PMCID: PMC8908068.
