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CDC Limits Review of Vaccinated But Infected. Harrison Among Those to Express Concern

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BLOOMBERG - Clinical trials weren’t designed to study how the vaccines perform in specific subgroups and people with certain medical conditions weren’t included, said EPI and IDM's Lee Harrison, also with PItt Medicine.   

Leadership transitions

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Dean Lichtveld announced upcoming leadership changes: Steve Albert to step down as BCHS chair with Velpandi Ayyavoo to serve as interim chair; Eleanor Feingold to become vice dean, Jessie Burke to interim as Feingold receives American Council on Education Fellowship. Dan Weeks will be interim chair of HUGEN.   

Sundermann and Harrison describe genomic surveillance and ending the COVID-19 pandemic

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THE CONVERSATION - Knowing the genome sequence helps researchers understand how the virus is mutating into variants and how it's traveling from person to person. Alexander Sundermann (IDM '14, EPI '22), EPI and IDM's Lee Harrison, and Pitt Medicine's Vaughn Cooper explain genomic surveillance - what it is and why we need more of it to track coronavirus variants and help end the COVID-19 pandemic.  

Pitt Public Health team wins third place at Morningside International Global Health Case Competition

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In collaboration with the Center for Global Health, Pitt held its first-ever Global Health Case Competition last fall. Pitt supported the winning team from that competition to enter Emory University's Morningside International Global Health Case Competition. Emily Crisan (BCHS '24) joined five undergraduate students and faculty mentor HPM's Elizabeth Van Nostrand and won third place out of 53 teams from across the U.S. for their plan and strateg... 

Marques among researchers looking for thousands of participants for COVID-19 study

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UPMC - "Excuse me, are you willing to answer a few survey questions about your experience with COVID-19? Will you provide a blood sample and a nasal swab to test for coronavirus?" Pitt is one of 15 sites nationwide involved in the COMPASS study that will survey residents around the Pittsburgh area to learn who has antibodies against SARS-CoV-2.   

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil

Multiple authors on behalf of the Microcephaly Epidemic Research Group, including IDM's Ernesto Marques, found the frequency of microcephaly in their results is consistent with previous studies. In addition, as children were evaluated at a later age and repeatedly by different groups of specialists our findings provide new insight into the absolute risk of more specific abnormalities, especially those more likely to be persistent, and suggest th... 

Frank receives Alumni Award from Pitt School of Education

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IDM's Linda Frank received the Distinguished Alumni Award from Pitt's School of Education for exceptional professional achievement, public service to the advancement of the educational field, and a commitment to the continued success of the school and the University. Award recipients will be honored at a virtual ceremony on March 25 at 5:30. Congratulations!   

‘Déjà vu’: HIV-positive Pittsburghers say we have much to learn about COVID by comparing it to our other deadly epidemic

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PUBLIC SOURCE — Pittsburghers who have lived with HIV for decades say the COVID pandemic echoed many of the scariest and most dangerous parts of living through the HIV and AIDS epidemic, including confusion about the science, social isolation, a reluctance to adopt public health measures, and a lack of presidential leadership. HIV disease persists, particularly among younger gay Black men living in the South, said Dr.  Mackey Friedman ,  “If yo... 

COVID-19 Update: As Pa. cases decline, did state avoid post-holiday surge?

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PITTSBURGH POST-GAZETTE — Lee Harrison, a Pitt epidemiologist and chairman of the Allegheny County Board of Health, said that the drop in the positivity rate was encouraging, but warned that the state is not done with the winter surge. “We’re in the middle still of a raging pandemic,” he said.  "I would encourage people to really continue to hunker down, stay safe, and, whenever their turn comes up to get vaccinated, get vaccinated.”  

Amanpour & Salk: Vaccine lessons from history (video)

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CNN — Christiane Amanpour discusses with IDM's Peter Salk the 97% drop in polio prevalence within a few years of initial vaccine adoption. In 1953, Dr. Peter Salk was one of the first to receive a polio vaccine—from none other than his father, Jonas Salk. They go on to discuss herd immunity and vaccine hesitancy both in 1954 and today.  

From polio to the COVID vaccine, IDM's Peter Salk sees great progress

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NPR - IDM's Peter Salk was just 9 when he got one of the first polio vaccine shots in 1953 at the family home outside Pittsburgh. Today, he has been hugely impressed by the development of a vaccine in less than a year. Dr. Salk is a bit concerned about the number of people who are reluctant, or outright opposed, to getting the vaccine. But he believes those numbers will shrink as people see the benefits. Until then, he'll be playing it safe.   

Covid-19 vaccine: Light faint at the end of the tunnel for Vietnam

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VNEXPRESS - Amid a global sigh of relief over vaccine developments, experts say Vietnam's access is fraught with uncertainty. IDM's Toan Ha said the country's ability to produce its own vaccines is critical. "I believe that Vietnam will be able to successfully develop clinically-tested Covid-19 vaccines in the near future. It is better to be self-reliant, being able to locally produce an affordable and safe vaccine than relying on foreign manufa... 

"It's going to be a long road" - What IDM's Peter Salk thinks about COVID-19

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USA TODAY - Jonas Salk’s vaccine helped wipe polio from most of the world, something that many people hope will happen with the coronavirus vaccine. However, IDM's Dr. Peter Salk warns eradicating polio from the U.S. was a long and difficult journey, and he doesn’t expect eliminating COVID-19 will be any easier. “It’s going to be a long road, just even getting enough vaccines out to people around the world."  

White House bet on Pfizer doses raises concerns about vaccine supply

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THE HILL - The Trump administration's decision not to purchase additional doses of Pfizer's COVID-19 vaccine could prove to be a risky gamble resulting in vaccination delays. IDM's Amy Hartman said it appeared that the administration was hedging its bets. "I think it's easy in hindsight to say yeah, they should have [secured more doses]." But Hartman was not sure why the U.S. would decline to buy more doses once they knew initial results wer... 

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Recent IDM Publications

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Rubio publishes thesis in Antimicrobial Agents and Therapy 

Rubio publishes thesis in Antimicrobial Agents and Therapy

Abigail Rubio (IDM '20) recently published In vitro Susceptibility of Multidrug-Resistant Pseudomonas aeruginosa following Treatment-emergent Resistance to Ceftolozane-tazobactam, comparing the in vitro susceptibility of multidrug-resistant Pseudomonas aeruginosa isolates 34 collected before and af... (04/20/2021)

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil 

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil

Multiple authors on behalf of the Microcephaly Epidemic Research Group, including IDM's Ernesto Marques, found the frequency of microcephaly in their results is consistent with previous studies. In addition, as children were evaluated at a later age and repeatedly by different groups of specialists... (03/19/2021)

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts 

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts

Amy L. Hartman, Sham Nambulli, Cynthia M. McMillen, Alexander G. White, Natasha Louise Tilston-Lunel, Joseph R. Albe, Emily Cottle, Matthew D. Dunn, L. James Frye, Theron H. Gilliland, Emily L. Olsen, Katherine J. O’Malley, Madeline M. Schwarz, Jaime A. Tomko, Reagan C. Walker, Mengying Xia, Matthe... (11/17/2020)

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function 

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function

Colleen R. Zaccard, Lauren Shapiro, Maria D. Martin-de-Saavedra, Christopher Pratt, Kristoffer Myczek, Amy Song, Marc P. Forrest, Peter Penzes Dendritic spinules are thin protrusions, formed by neuronal spines, not adequately resolved by diffraction-limited light microscopy, which has limit... (11/17/2020)
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Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States 

Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States

AIDS AND BEHAVIOR - Friedman, MR, Sang, JM, Bukowski, LA, Chandler, CJ, Egan, JE, Eaton, LA, Matthews, DD, Ho, K, Raymond, HF, & Stall, R. found that PrEP awareness campaigns tailored for black men who have sex with men and women (MSMW), concomitant with STI-to-PrEP interventions, will facilitate g... (10/14/2019)
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Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions 

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

JOURNAL OF VIROLOGY - Using samples from participants in the Multicenter AIDS Cohort study, Garcia-Bates, Palma, Shen, Gambotto, Macatangay, Ferris, Rinaldo, and Mailliard showed that PD-1 activation plays a positive role in initiating the primary T cell response. But later blocking of that pathway... (12/13/2018)

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)