Maria Mori Brooks, PhD

My research has focused on the design, conduct, and analysis of multicenter clinical trials and cohort studies.  Most of my work has involved the evaluation of treatments and risk factors in patients with coronary artery disease, diabetes and blood disorders and the epidemiology of cardiovascular diseases and women’s health. I am the Principal Investigator of the Coordinating Center of the Study of Women's Health Across the Nation (SWAN), a multi-racial/ethnic longitudinal cohort study designed to characterize the physiological and psychosocial changes that occur during the menopausal transition. In addition, I am the Principal Investigator of the Data Coordinating Center for the Myocardial Ischemia and Transfusion (MINT) trial, a multicenter randomized clinical trial evaluating transfusion strategies for patients with acute myocardial infarction and anemia and of the Data Coordinating Center for the Sickle Cell Disease and Cardiovascular Risk - Red cell Exchange (SCD-CARRE) trial, a randomized clinical trial evaluating the effectiveness of automated exchange transfusion for adult patients with sickle cell disease. I am also a co-Investigator on the INHIBIT Clinical Trials Platform, two linked randomized clinical trials, the Inhibitor Prevention Trial and the Inhibitor Eradication Trial, that utilize a Bayesian adaptive design to evaluate treatment regimens for patients with severe hemophilia A. Over the years, I have collaborated on projects involving genetics, infectious diseases, and behavioral interventions. I teach advanced epidemiological methods.

1985 | Williams College, Williamstown, MA | Bachelor of Arts, Mathematics, cum laude 

1986 | Harvard University, Cambridge, MA | Master of Arts, Statistics 

1991 | University of North Carolina, Chapel Hill, NC | PhD, Statistics

2006-2012 | EPIDEM 2180: Epidemiological Methods 1

2012-2018 | EPIDEM 2187: Epidemiological Methods 2

2019-Present | EPIDEM 2180: Epidemiological Methods 1

Lin HS, Naimi AI, Brooks MM, Richardson GA, Burke JG, Bromberger JT. Child maltreatment as a social determinant of midlife health-related quality of life in women: do psychosocial factors explain this association? Quality of Life Research. 2018. Dec;27(12):3243-3254. PMID: 30121897. PMCID: PMC7366611. 

Farkouh ME, Sidhu MS, Brooks MM, Vlachos H, Boden WE, Frye RL, Hartigan P, Siami FS,  Bittner VA, Chaitman BR, Mancini GBJ, Fuster V. Impact of Chronic Kidney Disease on Outcomes of Myocardial Revascularization in Patients With Diabetes. Journal of the American College of Cardiology. 2019 Feb 5;73(4):400-411. PMID: 30704571. PMCID: N/A.

Johnson CR, Brown K, Hyman SL, Brooks MM, Aponte C, Levato L, Schmidt B, Evans V, Huo Z, Bendixen R, Eng H, Sax T, Smith T. Parent Training for Feeding Problems in Children With Autism Spectrum Disorder: Initial Randomized Trial. Journal of Pediatric Psychology. 2019 Mar 1;44(2):164-175. PMID: 30101320. PMCID: PMC6365095.

Green DJ, Brooks MM, Burckart GJ, Chinnock RE, Canter C, Addonizio LJ, Bernstein D, Kirklin JK, Naftel DC, Girnita DM, Zeevi A, Webber SA. The Influence of Race and Common Genetic Variations on Outcomes After Pediatric Heart Transplantation. American Journal of Transplanttion. 2017 Jun;17(6):1525-1539. PMID: 27931092.  PMCID: N/A

Matthews KA, El Khoudary SR, Brooks MM, Derby CA, Harlow SD, Barinas-Mitchell EJ, Thurston RC. Lipid Changes Around the Final Menstrual Period Predict Carotid Subclinical Disease in Postmenopausal Women. Stroke. 2017 Jan;48(1):70-76. PMID: 27909203.   PMCID: PMC5183479.

Tepper PG, Brooks MM, Randolph JF Jr, Crawford SL, El Khoudary SR, Gold EB, Lasley BL, Jones B, Joffe H, Hess R, Avis NE, Harlow S, McConnell DS, Bromberger JT, Zheng H, Ruppert K, Thurston RC. Characterizing the trajectories of vasomotor symptoms across the menopausal transition. Menopause. 2016 Oct;23(10):1067-74. PMID:27404029. PMCID: PMC5028150.

Mancini GB, Farkouh ME, Brooks MM, Chaitman BR, Boden WE, Vlachos H, Hartigan PM, Siami FS, Sidhu MS, Bittner V, Frye R, Fuster V. Medical Treatment and Revascularization Options in Patients With Type 2 Diabetes and Coronary Disease. Journal of the American College of Cardiology. 2016 Sep 6;68(10):985-95. PMID: 27585501. PMCID: N/A

Bertolet M, Brooks MM, Bittner V. Tree-based identification of subgroups for time-varying covariate survival data. Statistical Methods Medical Research. 2016 Feb;25(1):488-501. PMID: 23070595. PMCID: PMC5575745. 

Nguyen-Ha P, Howrie D, Crowley K, Vetterly CG, McGhee W, Berry D, Ferguson E, Polischuk E, Brooks MM, Goff J, Stillwell T, Darville T, Thompson AE, Levin JE, Michaels MG, Green M. A Quality Assessment of a Collaborative Model of a Pediatric Antimicrobial Stewardship Program. Pediatrics. 2016;137(5):e20150316. PMCID: N/A.  

Everett BM, Brooks MM, Vlachos HE, Chaitman BR, Frye RL, Bhatt DL; BARI 2D Study Group. Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes. New England Journal of Medicine. 2015 Aug 13;373(7):610-20. doi: 10.1056/NEJMoa1415921. PMID: 26267622. PMCID: PMC4627639. 

Chen YF, Yabes JG, Brooks MM, Singh S, Weissfeld LA. A likelihood ratio test for nested proportions. Statistics in Medicine. 2015;34(3):525-38. PMID:25394913. PMCID: PMC4289453. 

El Khoudary SR, Brooks MM, Thurston RC, Matthews KA. Lipoprotein subclasses and endogenous sex hormones in women at midlife. J Lipid Res. 2014 May 22;55(7):1498-1504. PMID: 24852168. PMCID: PMC4076076. 

Althouse AD, Abbott JD, Sutton-Tyrrell K, Forker AD, Lombardero MS, Buitrón LV, Pena-Sing I, Tardif JC, Brooks MM, BARI 2D Study Group. Favorable effects of insulin sensitizers pertinent to peripheral arterial disease in type 2 diabetes: results from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Diabetes Care. 2013 Oct; 36 (10):3269-75. PMID: 23735723. PMCID: PMC3781574.

Carson JL, Brooks MM, Abbott JD, Chaitman B, Kelsey SF, Triulzi DJ, Srinivas V, Menegus MA, Marroquin OC, Rao SV, Noveck H, Passano E, Hardison RM, Smitherman T, Vagaonescu T, Wimmer NJ, Williams DO. Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. American Heart Journal. 2013 Jun; 165 (6):964-971.e1. PMID: 23708168. PMCID: PMC3664840.

Brooks MM, Chaitman BR, Nesto RW, Hardison RM, Feit F, Gersh BJ, Krone RJ, Sako EY, Rogers WJ, Garber AJ, King SB 3rd, Davidson CJ, Ikeno F, Frye RL, BARI 2D Study Group. Clinical and angiographic risk stratification and differential impact on treatment outcomes in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Circulation. 2012 Oct 23; 126 (17):2115-24. PMID: 23008442. PMCID: PMC4104411. 

Brooks MM, Chung SC, Helmy T, Hillegass WB, Escobedo J, Melsop KA, Massaro EM, McBane RD, Hyde P, Hlatky MA; the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Study Group. Health Status After Treatment for Coronary Artery Disease and Type 2 Diabetes Mellitus in the Bypass Angioplasty Revascularization Investigation 2 Diabetes Trial. Circulation. 2010;122:1690-99. PMID: 20937978. PMCID: PMC2964421.

The BARI 2D Study Group. A randomized trial of therapies for type 2 diabetes and coronary artery disease. New England Journal of Medicine. 2009; 360:2503-15. 

Hlatky MA, Boothroyd DB, Bravata DM, Boersma E, Booth J, Brooks MM, Carrié D, Clayton TC, Danchin N, Flather M, Hamm CW, Hueb WA, Kähler J, Kelsey SF, King SB, Kosinski AS, Lopes N, McDonald KM, Rodriguez A, Serruys P, Sigwart U, Stables RH, Owens DK, Pocock SJ. Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis of individual patient data from ten randomised trials. Lancet. 2009; 4:373:1190-7. PMID: 19303634. PMCID: NA.