Udai B Pandey

• Mann JR, McKenna ED, Mawrie D, Papakis V, Alessandrini F, Anderson EN, Mayers R, Ball HE, Kaspi E, Lubinski K, Baron DM, Tellez L, Landers JE, Pandey UB, Kiskinis E. Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import. Sci Adv. 2023 Aug 18;9(33):eadi5548. doi: 10.1126/sciadv.adi5548. Epub 2023 Aug 16. PMID: 37585529; PMCID: PMC10431718.
• Fortuna TR, Kour S, Chimata AV, Muiños-Bühl A, Anderson EN, Nelson Iv CH, Ward C, Chauhan O, O'Brien C, Rajasundaram D, Rajan DS, Wirth B, Singh A, Pandey UB. SMN regulates GEMIN5 expression and acts as a modifier of GEMIN5-mediated neurodegeneration. Acta Neuropathol. 2023 Sep;146(3):477-498. doi: 10.1007/s00401-023-02607-8. Epub 2023 Jun 27. PMID: 37369805.
• Boyd-Shiwarski CR, Shiwarski DJ, Griffiths SE, Beacham RT, Norrell L, Morrison DE, Wang J, Mann J, Tennant W, Anderson EN, Franks J, Calderon M, Connolly KA, Cheema MU, Weaver CJ, Nkashama LJ, Weckerly CC, Querry KE, Pandey UB, Donnelly CJ, Sun D, Rodan AR, Subramanya AR. WNK kinases sense molecular crowding and rescue cell volume via phase separation. Cell. 2022 Nov 23;185(24):4488-4506.e20. doi: 10.1016/j.cell.2022.09.042. Epub 2022 Oct 31. PMID: 36318922; PMCID: PMC9699283.
• Kour S, Rajan DS, Fortuna TR, Anderson EN, Ward C, Lee Y, Lee S, Shin YB, Chae JH, Choi M, Siquier K, Cantagrel V, Amiel J, Stolerman ES, Barnett SS, Cousin MA, Castro D, McDonald K, Kirmse B, Nemeth AH, Rajasundaram D, Innes AM, Lynch D, Frosk P, Collins A, Gibbons M, Yang M, Desguerre I, Boddaert N, Gitiaux C, Rydning SL, Selmer KK, Urreizti R, Garcia-Oguiza A, Osorio AN, Verdura E, Pujol A, McCurry HR, Landers JE, Agnihotri S, Andriescu EC, Moody SB, Phornphutkul C, Sacoto MJG, Begtrup A, Houlden H, Kirschner J, Schorling D, Rudnik-Schöneborn S, Strom TM, Leiz S, Juliette K, Richardson R, Yang Y, Zhang Y, Wang M, Wang J, Wang X, Platzer K, Donkervoort S, Bönnemann CG, Wagner M, Issa MY, Elbendary HM, Stanley V, Maroofian R, Gleeson JG, Zaki MS, Senderek J, Pandey UB. Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder. Nature Comm. 2021 May 7;12(1):2558.
• Anderson EN, Morera AA, Kour S, Cherry JD, Ramesh N, Gleixner A, Schwartz JC, Ebmeier C, Old W, Donnelly CJ, Cheng JP, Kline AE, Kofler J, Stein TD,Pandey UB. Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology. eLife. 2021 May 26;10:e67587. PMID: 34060470
• Fortuna TR, Kour S, Anderson EN, Ward C, Rajasundaram D, Donnelly CJ, Wyne H, Shewmaker F, Pandey UB. DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner. Acta Neuropathol. 2021 June 1. doi: 10.1007/s00401-021-02333-z&nbsp
• Lin YC, Kumar MS, Ramesh N, Anderson EN, Nguyen AT, Kim B, Cheung S, McDonough JA, Skarnes WC, Lopez-Gonzalez R, Landers JE, Fawzi NL, Mackenzie IRA, Lee EB, Nickerson JA, Grunwald D, Pandey UB, Bosco DA. Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway. Nature Neurosci. 2021 May 31. doi: 10.1038/s41593-021-00859-9. Epub ahead of print. PMID: 34059832
• Anderson A, Gochenaur L, Singh A, Grant R, Patel K, Watkins S, Wu J, Pandey UB. Traumatic injury induces Stress Granule Formation and enhances Motor Dysfunctions in ALS
• Models. Hum Mol Genet. 2018 Apr 15;27(8):1366-1381.
• Bakthavachalu B, Huelsmeier J, Sudhakaran I, Hillebrand J, Singh A, Petrauskas A, Thiagarajan D, Sankaranarayanan M, Mizoe L, Anderson EA, Pandey UB, Ross E,
• VijayRaghavan K, Parker R, Ramaswami M. RNP-granules assembly via Ataxin02
• disordered domains is required for long-term memory and neurodegeneration. Neuron. 2018 May 16;98(4):754-766
• *Previewed in ‘Neuron’
• Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM,
• Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell
• CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 2018 Apr 19;173(3):677-692
• Marrone L, Japtok J, Reinhardt P, Janosch A, Andree A, Lee H, Moebius C, Reinhardt L,
• Hackmann K, Klink B, Alberti S, Bickle M, Hyman AA, Casci I, Pandey UB, Hermann A, and Sterneckert J. Phenotypic screening using iPSC reporter lines identifies brain-penetrant drugs stimulating autophagy as therapeutics for FUS-ALS. Stem Cell Reports 2018 Feb 13;10(2):375-389.
• Kim SH, Stiles SG, Feichtmeier JM, Ramesh N, Zhan L, Scalf MA, Smith LM, Pandey
• UB, Tibbetts RS. Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS. Hum Mol Genet. 2018 Jan 15;27(2):322-337
• Rudich P, Snoznik C, Watkins SC, Monaghan J, Pandey UB, Lamitina T. Nuclear localized C9orf72 associated arginine containing dipeptides exhibit age-dependent toxicity in C. elegans. Hum Mol Genet 2017 Dec 15;26(24):4916-492
• Ramesh N, Pandey UB, Proteostasis dysfunction in ALS: Autophagy eating its way
• to prominence. Front Mol Neurosci (2017) Aug 22; 10:263
• Daigle JG, Krishnamurthy K, Ramesh R, Casci I, Monaghan J, McAvoy K, Godfrey GW, Daniel D, Johnson E, Monahan Z, Shewmaker F, Pasinelli P, Pandey UB. Pur alpha ameliorates FUS toxicity and regulates cytoplasmic stress granule dynamics. Acta Neuropathological 2016 Jan 4
• Scaramuzzino C, Casci I, Parodi S, Lievens PMJ, Milioto C, Polanco MJ, Chivet M, Mishra A, Badders N, Aggarwal N, Grunseich C, Sambataro F, Basso M, Fackelmayer FO, Taylor JP, Pandey UB and Pennuto M. Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy. Neuron 2015 Jan 7; 84(7)
• Casci I and Pandey UB. A Fruitful Endeavor: Modeling ALS in the Fruit Fly. Brain Research 2015 May 14;1607:47-74
• Wen X, Tan W, Westergard T, Krishnamurthy K, Shamamandri Markandaiah S, Lin S, Ichida JK, Monaghan J, Pandey UB, Pasinelli P and Trotti D. Antisense Proline-Arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death, Neuron 2014 Dec 17;84(6)
• Shahidullah M, Le Marchand SJ, Fei H, Zhang J, Pandey UB, Dalva MB, Pasinelli P, Levitan IB. Defects in Synapse Structure and Function Precede Motor Neuron Degeneration in Drosophila Models of FUS-Related ALS. J Neurosci. 2013 Dec 11;33(50):19590-8
• Daigle JG, Lanson NA, Smith RB, Casci I, Maltare A, Monaghan J, Nichols CD, Kryndushkin D, Shewmaker F, Pandey UB. RNA binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations. Human Molecular Genetics 2013 Mar 15;22(6):1193-205.
• Lanson NA, Pandey UB. FUS-related Proteinpathies: Lessons from Animal Models. Brain Research 2012 Jun 26;1462:44-60.
• Lanson NA, Maltare A, King H, Smith R, Kim JH, Taylor JP, Lloyd TE and Pandey UB. A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. Human Molecular Genetics 2011 Jul 1;20(13):2510-23.
• Batlevi Y, Simon C, Pandey UB, Powers C, Taylor JP, and Baehrecke EH. Dynein light chain 1 is required for autophagy, protein clearance and cell death in Drosophila, PNAS, 2010 107, 2
• Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, Schwartz SL, DiProspero NA, Knight MA, Schuldiner O, Padmanabhan R, Hild M, Berry DL, Garza D, Hubbert CC, Yao TP, Baehrecke EH, Taylor JP. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature. 2007 Jun 14; 447(7146):860-4.
• *Previewed in Neuron and selected for ‘must read paper’ by faculty 1000 biology.
• Pandey UB, Batlevi Y, Baehrecke EH, Taylor JP. HDAC6 at the Intersection of Autophagy, the Ubiquitin-proteasome System, and Neurodegeneration. Autophagy. 2007, 3 (6)

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