My primary research interests include the design and analysis of clinical trials. Specifically, multi-center clinical trials. I am currently coordinating multi-center trials of traumatic brain injury, psychiatric disorder, pulmonary disorders and trauma induced coagulopathy.
1994 | University of Pittsburgh, Pittsburgh, PA | PhD, Epidemiology
1988 | The Ohio State University, Columbus, Ohio | MAS, Statistics
1987 | The Pennsylvania State University, University Park, PA | BS, Mathematics
My teaching experience in the Department of Epidemiology has focused on epidemiological methods. Over the course of my career I have been the primary instructor or a visiting lecturer for both Epidemiology 2180 (Epidemiology Method 1) and Epidemiology 2230 (Epidemiology Methods 2).
My primary research interests include the design and analysis of clinical trials. Specifically, multi-center clinical trials. I am currently coordinating multi-center trials evaluating treatments of traumatic injuries, glaucoma, cerebral palsy, and cardiac defects in newborns.
From over 450 peer-reviewed publications
- Sperry JL, Guyette FX, Rosario-Rivera BL, Kutcher ME, Kornblith LZ, Cotton BA, Wilson CT, Inaba K, Zadorozny EV, Vincent LE, Harner AM, Love ET, Doherty JE, Cuschieri J, Kornblith AE, Fox EE, Bai Y, Hoffman MK, Seger CP, Hudgins J, Mallett-Smith S, Neal MD, Leeper CM, Spinella PC, Yazer MH, Wisniewski SR. Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial. Annals of Surgery. 280(2):212-221, 2024 Aug 01.
- Bell MJ, Rosario BL, Kochanek PM, Adelson PD, Morris KP, Au AK, Schober M, Butt W, Edwards RJ, Zimmerman J, Pineda J, Le TM, Dean N, Whalen MJ, Figaji A, Luther J, Beers SR, Gupta DK, Carpenter J, Buttram S, Wisniewski SR, Approaches and Decisions for Acute Pediatric TBI (ADAPT) Investigators. Comparative Effectiveness of Diversion of Cerebrospinal Fluid for Children With Severe Traumatic Brain Injury. JAMA Network Open, 5(7):e2220969, 2022 07 01.
- Brooks MM, Wisniewski SR. Assessing Unexpected Circumstances That Lead to Modifications in Clinical Trial Design, Conduct, or Analysis: Application of the CONSERVE Reporting Guideline. Journal of the American Medical Association, 2022;327:868–869. doi:10.1001/jama.2022.1748.
- Connors JM, Brooks MM, Sciurba FC, Krishnan JA, Bledsoe JR, Kindzelski A, Baucom AL, Kirwan BA, Eng H, Martin D, Zaharris E, Everett B, Castro L, Shapiro NL, Lin JY, Hou PC, Pepine CJ, Handberg E, Haight DO, Wilson JW, Majercik S, Fu Z, Zhong Y, Venugopal V, Beach S, Wisniewski S, Ridker PM. Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19: The ACTIV-4B Randomized Clinical Trial. JAMA. 326(17):1703-1712, 2021 11 02. https://dx.doi.org/10.1001/jama.2021.17272
- Forno E, Bacharier LB, Phipatanakul W, Guilbert TW, Cabana MD, Ross K, Covar R, Gern JE, Rosser FJ, Blatter J, Durrani S, Han Y-Y, Wisniewski SR, Celedón JC. Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children with Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial. Journal of the American Medical Association, 2020;324:752-760. doi: 10.1001/jama.2020.12384
- Mannix, R, Zemek R, Yeates KO, Arbogast K, Atabaki S, Badawy M, Beauchamp MH, Beer D, Bin S, Burstein B, Craig W, Corwin D, Doan Q, Ellis M, Freedman SB, Gagnon I, Gravel J, Leddy J, Lumba-Brown A, Master C, Mayer AR, Park G, Penque M, Rhine T, Russell K, Schneider K, Bell M, Wisniewski SR. Practice patterns in pharmacological and non-pharmacological therapies for children with mild traumatic brain injury: A survey of 15 Canadian and United States centers. Journal of Neurotrauma, 2019,36: 2886-2894.
- Wisniewski SR, Rush AJ, Nierenberg AA, Gaynes BN, Warden D, Luther JF, McGrath PJ, Lavori PW, Thase ME, Fava M, Trivedi MH. Can Phase III Trial Results of Antidepressant Medications be Generalized to Clinical Practice? A STAR*D Report. American Journal of Psychiatry, 2009;166;599-607. PMID: 19339358
- Sachs GS, Nierenberg AA, Calabrese JR, Marangell LB, Wisniewski SR, Gyulai L, Friedman ES, Bowden CL, Fossey MD, Ostacher MJ, Ketter TA, Patel J, Hauser P, Rapport D, Martinex JM, Allen MH, Miklowitz DJ, Otto MW, Dennehy EB, Thase ME. Effectiveness of Adjunctive Antidepressant Treatment for Bipolar Disorder. The New England Journal of Medicine, 2007:356:1711-1722. PMID: 17392295
- Trivedi MH, Fava M, Wisniewski SR, Thase ME, Quitkin F, Warden D, Ritz L, Nierenberg A, Lebowitz BD, Biggs MM, Luther JF, Shores-Wilson K, Rush AJ for the STAR*D Study Team. A Comparison of Citalopram Augmentation with Bupropion-SR and Buspirone Following SSRI Failure for Depressed Outpatients: A STAR*D Report. New England Journal of Medicine, 2006;354:1243-1252. PMID: 16554526.
- Rush AJ, Trivedi MH, Wisniewski SR, Stewart JW, Nierenberg A, Thase ME, Ritz L, Biggs MM, Warden D, Luther JF, Shores-Wilson K, Niederehe G, Fava M for the STAR*D Team. A Comparison of Bupropion-SR, Sertraline, and Venlafaxine-XR Following SSRI Failure for Depressed Outpatients: A STAR*D Report. New England Journal of Medicine, 2006;354:1231-1242. PMID: 16554525
