My research interests primarily focuses on oxidative stress, peroxidase activity of hemoproteins, lipid peroxidation as death signals inducing ferroptotic cell death. I also interested in oxidative biodegradation of carbon nanomaterials.
2000 | Kyiv University, Kyiv, Ukraine | Doctor of Sciences in Biochemistry
1986 | Institute of Biochemistry Ukrainian Academy of Sciences, Kyiv, Ukraine | PhD in Biochemistry
1979 | Kyiv State University, Kyiv, Ukraine | Master of Science in General and Molecular Genetics
Vlasova II,Kapralov AA, Michael ZP, Burkert SC, Shurin MR, Star A, Shvedova AA, KaganVE. Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications. Toxicol Appl Pharmacol. 2016 May 15;299:58-69
Tejero J,Kapralov AA, Baumgartner MP, Sparacino-Watkins CE, Anthonymutu TS, Vlasova II, Camacho CJ, Gladwin MT, Bayir H, Kagan VE.Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences.Biochim Biophys Acta. 2016 May;1861(5):391-401
Bakan A,Kapralov AA, Bayir H, Hu F, Kagan VE, Bahar I.Inhibition of Peroxidase Activity of Cytochrome c: De Novo Compound Discovery and Validation. Mol Pharmacol. 2015; 88(3):421-7
Seo W,Kapralov AA, Shurin GV, Shurin MR, Kagan VE, Star A. Payload drug vs. nanocarrier biodegradation by myeloperoxidase- and peroxynitrite-mediated oxidations: pharmacokinetic implications. Nanoscale. 2015 May 7;7(19):8689-94. PMID:25902750.
Yanamala N,Kapralov AA, Djukic M, Peterson J, Mao G, Klein-Seetharaman J, Stoyanovsky DA, Stursa J, Neuzil J, Kagan VE. Structural re-arrangement and peroxidase activation of cytochrome c by anionic analogues of vitamin E, tocopherol succinate and tocopherol phosphate. The Journal of Biological Chemistry. 2014 Nov 21;289(47):32488-98. PMID:25278024.
Kagan VE,Kapralov AA, St Croix CM, Watkins SC, Kisin ER, Kotchey GP, Balasubramanian K, Vlasova II, Yu J, Kim K, Seo W, Mallampalli RK, Star A, Shvedova AA. Lung Macrophages “Digest” Carbon Nanotubes Using a Superoxide/Peroxynitrite Oxidative Pathway. ACS Nano. 2014 Jun 4. PMID: 24871084.
Jiang J, Bakan A,Kapralov AA, Ishara Silva K, Huang Z, Amoscato AA, Peterson J, Krishna Garapati V, Saxena S, Bayir H, Atkinson J, Bahar I, Kagan VE. Designing inhibitors of cytochrome c/cardiolipin peroxidase complexes: mitochondria-targeted imidazole-substituted fatty acids. Free Radical Biology & Medicine. 2014 Jun; 71:221-30. PMID: 24631490.
Tyurina YY, Poloyac SM, Tyurin VA,Kapralov AA, Jiang J, Anthonymuthu TS, Kapralova VI, Vikulina AS, Jung MY, Epperly MW, Mohammadyani D, Klein-Seetharaman J, Jackson TC, Kochanek PM, Pitt BR, Greenberger JS, Vladimirov YA, Bayir H, Kagan VE. A mitochondrial pathway for biosynthesis of lipid mediators. Nature Chemistry. 2014 Jun; 6 (6):542-52. PMID: 24848241.
Tyurin VA, Balasubramanian K, Winnica D, Tyurina YY, Vikulina AS, He RR,Kapralov AA, Macphee CH, Kagan VE. Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic ‘eat-me’ signals: cleavage and inhibition of phagocytosis by Lp-PLA2. Cell Death and Differentiation. 2014 May; 21 (5):825-35. PMCID: PMC3978307. PMID: 24464221.
Chu CT, Ji J, Dagda RK, Jiang JF, Tyurina YY,Kapralov AA, Tyurin VA, Yanamala N, Shrivastava IH, Mohammadyani D, Qiang Wang KZ, Zhu J, Klein-Seetharaman J, Balasubramanian K, Amoscato AA, Borisenko G, Huang Z, Gusdon AM, Cheikhi A, Steer EK, Wang R, Baty C, Watkins S, Bahar I, Bayir H, Kagan VE. Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nature Cell Biology. 2013 Oct; 15 (10):1197-205. PMCID: PMC3806088. PMID: 24036476.
Andón FT,Kapralov AA, Yanamala N, Feng W, Baygan A, Chambers BJ, Hultenby K, Ye F, Toprak MS, Brandner BD, Fornara A, Klein-Seetharaman J, Kotchey GP, Star A, Shvedova AA, Fadeel B, Kagan VE. Biodegradation of single-walled carbon nanotubes by eosinophil peroxidase. Small (Weinheim An Der Bergstrasse, Germany). 2013 Aug 26; 9 (16):2721-9, 2720. PMCID: PMC4039041. PMID: 23447468.
Kotchey GP, Gaugler JA,Kapralov AA, Kagan VE, Star A. Effect of antioxidants on enzyme-catalysed biodegradation of carbon nanotubes. Journal of materials chemistry. B, Materials for biology and medicine. 2013; 1 (3):302-309. PMCID: PMC3634595. PMID: 23626907.
Kapralov AA, Feng WH, Amoscato AA, Yanamala N, Balasubramanian K, Winnica DE, Kisin ER, Kotchey GP, Gou P, Sparvero LJ, Ray P, Mallampalli RK, Klein-Seetharaman J, Fadeel B, Star A, Shvedova AA, Kagan VE. Adsorption of surfactant lipids by single-walled carbon nanotubes in mouse lung upon pharyngeal aspiration. ACS Nano. 2012 May 22; 6 (5):4147-56. PMCID: PMC3358590. PMID: 22463369.
