IDM Department News

Nachega recognized by African Science Institutions

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The African Academy of Sciences elected IDM and EPI's Jean Nachega a fellow in recognition of his efforts to develop patient care, teaching, and research around epidemiology and infectious diseases in Africa. In addition, the Academy of Sciences of South Africa - which aims to provide evidence-based scientific advice on issues of public interest - named him a member-elect.  

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

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JOURNAL OF VIROLOGY - Using samples from participants in the Multicenter AIDS Cohort study, Garcia-Bates, Palma, Shen, Gambotto, Macatangay, Ferris, Rinaldo, and Mailliard showed that PD-1 activation plays a positive role in initiating the primary T cell response. But later blocking of that pathway can enhance the overall magnitude of the immune system’s ability to remember and respond to HIV.   

Hartman and team study tropical mosquito-borne virus linked to miscarriage, stillbirth in animals

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WESA-FM - Research suggests the Rift Valley Fever can affect developing human fetuses. IDM's Amy Hartman, along with first author Cynthia McMillen who is an IDM postdoc, chose to study Rift Valley’s effects on pregnant rats, since humans and rats have similar placental structures. They found that 65 percent of pups born to infected rats died, even when the mother rats appeared healthy.   

Frank on why, after more than 30 years, there is still no vaccine for HIV

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KDKA-AM - More than 30 years after HIV was uncovered there is still no AIDS vaccine, but IDM's Linda Frank, who heads the MidAtlantic AIDS Education and Training Center, says, “People who are uninfected can take anti-retrovirals to prevent them from getting HIV infected. This is so wonderful.” Frank says the new frontier in HIV treatment is in conjunction with diseases like hepatitis, sexually transmitted disease, and substance abuse.  

County project tackling AIDS and HIV reports fewer new cases

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POST GAZETTE - Allegheny County health officials are reporting progress in the fight against AIDS by reducing new HIV cases. A key part of this effort is education. The MidAtlantic AIDS Education and Training Center, led by Linda Frank, has been involved in efforts to fight AIDS for the past 30 years. The World AIDS Day 2018 conference “is about the new treatments and advancements to help us get to zero new cases,” says Frank.  

Student Noreen Chatta shares her analysis of endoscope procedures and bacterial cultures at APHA 2018

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APHA - Noreen Chatta (IDM) presented her research on Safety of Gastrointestinal (GI) Endoscopic Procedures at a Large Academic Medical Center during a poster symposium at APHA's 2018 annual meeting. In this study, she assessed and monitored the safety of endoscopic procedures using microbiologic cultures and electronic medical records, evaluating for 30-day microbiologic results after endoscopic procedures.  

Pitt Men's Study mourns loss of doctor among the first in Pittsburgh to treat gay men and people with HIV

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The Pitt Men’s Study extends its heartfelt sympathy and condolences to all those touched by the shooting at the Tree of Life Synagogue in Squirrel Hill on October 27. While all the deaths that day were tragic, the death of Dr. Jerry Rabinowitz is particularly significant to our volunteers and staff. Dr. Rabinowitz was one of the first doctors in Pittsburgh to welcome both gay men and people with HIV into his practice.   

Turning ideas into transformative action: Pitt Public Health students selected as Future Health Leaders

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Complex health issues are easy to determine, but finding solutions can be challenging. Three Pitt Public Health students, ASHLEY SIMENSON (EPI ’19), JESSICA SALERNO (IDM ’20), and KAITLYN SAAL-RIDPATH (HPM ’20) were chosen as part of the inaugural class of Future Health Leaders to present their ideas at the Milken Institute's Future of Health Summit 2018 in Washington DC.  

Simenson, Salerno, Saal-Ridpath selected for future health leaders program

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PITT WIRE - Three students from Pitt Public Health were selected for the inaugural class of The Milken Institute’s Future Health Leaders Program. The students, ASHLEY SIMENSON (EPI '19), JESSICA SALERNO (IDM '20), and KAITLYN SAAL-RIDPATH (HPM '20), are among a dozen of fellows selected nationwide. The program aims to give the students exposure to health leadership to help accelerate their future work tackling complex public health challenges.... 

Human immunodeficiency virus infection induces lymphoid fibrosis in the BM-liver-thymus-spleen humanized mouse model

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JOURNAL OF CLINICAL INVESTIGATION INSIGHT - Jasmine Samal, Samantha Kelly, Ali Na-Shatal, Abdallah Elhakiem, Antu Das, Ming Ding, Anwesha Sanyal, Phalguni Gupta, Kevin Melody, Brad Roland, Watfa Ahmed, Aala Zakir, and Moses Bility developed a potentially novel human immune system–humanized mouse model.  

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Recent IDM Publications

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Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions 

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

JOURNAL OF VIROLOGY - Using samples from participants in the Multicenter AIDS Cohort study, Garcia-Bates, Palma, Shen, Gambotto, Macatangay, Ferris, Rinaldo, and Mailliard showed that PD-1 activation plays a positive role in initiating the primary T cell response. But later blocking of that pathway... (12/13/2018)

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)

Zika virus displacement by a chikungunya outbreak in Recife, Brazil 

Zika virus displacement by a chikungunya outbreak in Recife, Brazil

PUBLIC LIBRARY OF SCIENCE - Magalhaes, Braga, Cordeiro, Oliveira, Castanha, Maciel, Amancio, Gouveia, Peixoto-deSilva Jr., Peixoto, Britto, Lima, Lima, and Marques detected the tail end of a Zika epidemic in 2015-16 which was displaced by a chikungunya epidemic. Few dengue cases were identified des... (06/14/2018)

Rift Valley fever in animals and humans: Current perspectives 

Rift Valley fever in animals and humans: Current perspectives

ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease. (06/11/2018)

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN 

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.  (05/18/2018)

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury 

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM in... (05/18/2018)

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques 

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques

JOURNAL OF IMMUNOLOGY - Wonderlich, Swan, Bissel, Hartman, Carney, O'Malley, Obadan, Santos, Walker, Sturgeon, Frye, Maiello, Scanga, Bowling, Duangkhae, Wiley, Flynn, Wang, Cole, Reed, Barratt-Boyes establish a new nonhuman primate disease model for evaluation of vaccine and therapeutic approaches... (02/14/2018)

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IDM Videos

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Smith talks in-depth immunotherapy for lung cancer 

Smith talks in-depth immunotherapy for lung cancer

HOPE WITH ANSWERS - Discover in-depth information about immunotherapy for lung cancer through this conversation between Kellie Smith (IDM '13) of Johns Hopkins and patient advocate Lysa Buonanno, part of a video series providing the next level of information for patients to understand treatment opt... (08/12/2019)
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Hartman among researchers trying to prevent virus more dangerous than Zika (video) 

Hartman among researchers trying to prevent virus more dangerous than Zika (video)

WPXI - Pitt researchers are looking to lessons learned about Zika when preparing for the possibility of Rift Valley Fever virus, noting that it's important to develop therapies and vaccines now. "We saw the ffects of Zika when it got into a larger population and so our work highlights the need to r... (02/11/2019)
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Hernandez's research adds to pharmaceutical industry's growing pressure over high price of drugs 

Hernandez's research adds to pharmaceutical industry's growing pressure over high price of drugs

FOX NEWS - "It's not about innovation, it's about inflation in existing products," explains Inmaculada Hernandez (HPM '16). "They are the same companies that operate in other countries and they don't show this behavior and that's because in other countries they are lucky to have this regulatory env... (01/24/2019)
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IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO) 

IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO)

UPMC HEALTH NEWS – In the late 1990s, new and highly potent anti-HIV drugs emerged— including protease and reverse transcriptase inhibitors—which could for the first time control HIV infection. For this 1998 World AIDS Day, Pitt IDM AIDS researcher Charles Rinaldo and the late Bridget Murtagh of th... (07/17/2018)
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