IDM Department News

Early HIV Treatment Improves Survival in Some Patients with Newly Diagnosed TB

Starting anti-HIV treatment within two weeks of the diagnosis of tuberculosis, or TB, improved survival among patients with both infections who had very low immune-cell counts, according to an analysis by researchers at the University of Pittsburgh Graduate School of Health. Those with strong immune systems, however, might benefit from waiting until after the end of the six-month TB treatment before initiating anti-HIV therapy, they found.   

Call for Applications:PHDL International Student Fellowships

The Public Health Dynamics Lab (PHDL) is requesting applications for an International Student Fellowship Award that provides $5,000 to a Pitt Public Health graduate student. 

Special Epidemiology Seminar - Perspectives on Ebola

A special seminar on the Ebola Outbreak hosted by the Department of Epidemiology. 

Experts examine HIV/AIDS epidemic in Pittsburgh area

“It’s important to remember that the epidemic is not over and still growing in the United States and around the world,” said Linda Frank, director of the Pennsylvania MidAtlantic AIDS Education and Training Center.Read the Post-Gazette article.  

NEW Multidisciplinary Group! Pitt Trauma & Emergency League

The Pitt Trauma & Emergency League (PTEL) is a group of public health, nursing, medical, undergraduate emergency medicine and pre-health students. 

Low Cholesterol in Immune Cells Tied to Slow Progression of HIV

People infected with HIV whose immune cells have low cholesterol levels experience much slower disease progression, even without medication, according to University of Pittsburgh Graduate School of Public Health research that could lead to new strategies to control infection. 

Pitt Public Health Analysis Challenges Assumptions About Bisexual Men and HIV Transmission

The number of HIV positive men who have sex with both men and women is likely no higher than the number of HIV positive heterosexual men, according to a U.S.-based analysis by University of Pittsburgh Graduate School of Public Health researchers. The finding challenges a popular assumption that bisexual men are responsible for significant HIV transmission to their female partners.  

Considerable Gender, Racial and Sexuality Differences Exist in Attitudes Toward Bisexuality

Men who identify themselves as heterosexual are three times more likely to categorize bisexuality as "not a legitimate sexual orientation," an attitude that can encourage negative health outcomes in people who identify as bisexual, according to an analysis led by University of Pittsburgh Graduate School of Public Health researcher Mackey Friedman, Ph.D., M.P.H.  

Debra Cen (IDM '91)

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A passion for science, business, and American culture has propelled Hui “Debra” Cen (ScDHy ’91) to a sweet spot. Having sold one successful biotech start-up and handed off another, the Silicon Valley entrepreneur is now turning her attention to a high-tech way to promote the cultural strength of the United States and China to each other. 

Pitt Researchers Plan CFAR Application for 2013

On December 18, 2012, twelve HIV-AIDS researchers from the University of Pittsburgh established a Pitt CFAR Planning Working Group (PCPWG) to prepare an application to the NIH for a CFAR. Such designation would allow the University to build on its 30 year history of HIV-AIDS research. It was agreed we will proceed with the development of a regular CFAR proposal for submission June, 2013. 

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Recent IDM Publications

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Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions 

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

JOURNAL OF VIROLOGY - Using samples from participants in the Multicenter AIDS Cohort study, Garcia-Bates, Palma, Shen, Gambotto, Macatangay, Ferris, Rinaldo, and Mailliard showed that PD-1 activation plays a positive role in initiating the primary T cell response. But later blocking of that pathway... (12/13/2018)

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)

Zika virus displacement by a chikungunya outbreak in Recife, Brazil 

Zika virus displacement by a chikungunya outbreak in Recife, Brazil

PUBLIC LIBRARY OF SCIENCE - Magalhaes, Braga, Cordeiro, Oliveira, Castanha, Maciel, Amancio, Gouveia, Peixoto-deSilva Jr., Peixoto, Britto, Lima, Lima, and Marques detected the tail end of a Zika epidemic in 2015-16 which was displaced by a chikungunya epidemic. Few dengue cases were identified des... (06/14/2018)

Rift Valley fever in animals and humans: Current perspectives 

Rift Valley fever in animals and humans: Current perspectives

ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease. (06/11/2018)

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN 

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.  (05/18/2018)

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury 

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM in... (05/18/2018)

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques 

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques

JOURNAL OF IMMUNOLOGY - Wonderlich, Swan, Bissel, Hartman, Carney, O'Malley, Obadan, Santos, Walker, Sturgeon, Frye, Maiello, Scanga, Bowling, Duangkhae, Wiley, Flynn, Wang, Cole, Reed, Barratt-Boyes establish a new nonhuman primate disease model for evaluation of vaccine and therapeutic approaches... (02/14/2018)

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IDM Videos

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Smith talks in-depth immunotherapy for lung cancer 

Smith talks in-depth immunotherapy for lung cancer

HOPE WITH ANSWERS - Discover in-depth information about immunotherapy for lung cancer through this conversation between Kellie Smith (IDM '13) of Johns Hopkins and patient advocate Lysa Buonanno, part of a video series providing the next level of information for patients to understand treatment opt... (08/12/2019)
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Hartman among researchers trying to prevent virus more dangerous than Zika (video) 

Hartman among researchers trying to prevent virus more dangerous than Zika (video)

WPXI - Pitt researchers are looking to lessons learned about Zika when preparing for the possibility of Rift Valley Fever virus, noting that it's important to develop therapies and vaccines now. "We saw the ffects of Zika when it got into a larger population and so our work highlights the need to r... (02/11/2019)
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Hernandez's research adds to pharmaceutical industry's growing pressure over high price of drugs 

Hernandez's research adds to pharmaceutical industry's growing pressure over high price of drugs

FOX NEWS - "It's not about innovation, it's about inflation in existing products," explains Inmaculada Hernandez (HPM '16). "They are the same companies that operate in other countries and they don't show this behavior and that's because in other countries they are lucky to have this regulatory env... (01/24/2019)
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IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO) 

IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO)

UPMC HEALTH NEWS – In the late 1990s, new and highly potent anti-HIV drugs emerged— including protease and reverse transcriptase inhibitors—which could for the first time control HIV infection. For this 1998 World AIDS Day, Pitt IDM AIDS researcher Charles Rinaldo and the late Bridget Murtagh of th... (07/17/2018)
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