IDM Events

IDM Departmental Calendar

Event Category
Mon 9/9/2019 12:00PM - 1:00PM
Open House for Undergraduates IDM Seminar Series
Open House for Undergraduates
Mon 9/9/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 9/16/2019 12:00PM - 1:00PM
Presentation by Laurie Silva, PhD IDM Seminar Series
Presentation by Laurie Silva, PhD
Mon 9/16/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Fri 9/20/2019 8:30AM - 12:00PM
35th Anniversary of the Pitt Men's Study IDM Event
35th Anniversary of the Pitt Men's Study
Fri 9/20/2019 8:30AM - 12:00PM
Public Health Auditorium (G23)


Public Health Auditorium (G23)
IDM
Event
Mon 9/30/2019 12:00PM - 1:00PM
IDM Research Day Winners IDM Seminar Series
IDM Research Day Winners
Mon 9/30/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 10/7/2019 12:00PM - 1:00PM
"TBA" IDM Seminar Series
"TBA"
Mon 10/7/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Tue 10/8/2019 9:00AM - 4:30PM
PrEP Summit: Engagement, Adherence, Retention MidAtlantic AIDS Education and Training Center Conference
PrEP Summit: Engagement, Adherence, Retention
Tue 10/8/2019 9:00AM - 4:30PM
Outside Conference and Meeting Spaces


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference
Mon 10/14/2019 12:00PM - 1:00PM
Presentation by Dustin T. Duncan, ScD IDM Seminar Series
Presentation by Dustin T. Duncan, ScD
Mon 10/14/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 10/21/2019 12:00PM - 1:00PM
Presentations by: Subramanian Thothathri & Jason Yeung IDM Seminar Series
Presentations by: Subramanian Thothathri & Jason Yeung
Mon 10/21/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Tue 10/22/2019 5:00PM - 8:30PM
Erie Evening Update: Sexual Health and Stigma MidAtlantic AIDS Education and Training Center Conference
Erie Evening Update: Sexual Health and Stigma
Tue 10/22/2019 5:00PM - 8:30PM
Outside Conference and Meeting Spaces

This evening dinner update, in collaboration with the Erie Department of Health and Erie HIV Task Force, will be held at the Bayfront Convention Center.  The presenters will discuss Sexual Health History Taking and Sexual Health and Stigma, followed by a panel of local providers.


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference
Mon 10/28/2019 12:00PM - 1:00PM
Presentations by: Byron Chuan & Zachary Koenig IDM Seminar Series
Presentations by: Byron Chuan & Zachary Koenig
Mon 10/28/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/4/2019 12:00PM - 1:00PM
Presentation by Mari Webel, PhD IDM Seminar Series
Presentation by Mari Webel, PhD
Mon 11/4/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/11/2019 12:00PM - 1:00PM
Presentations by: Emily Olsen & Karsen Shoger IDM Seminar Series
Presentations by: Emily Olsen & Karsen Shoger
Mon 11/11/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/18/2019 12:00PM - 1:00PM
Presentations by: Victoria Gould & Katrina Stephenson IDM Seminar Series
Presentations by: Victoria Gould & Katrina Stephenson
Mon 11/18/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 12/2/2019 12:00PM - 1:00PM
Presentation by: Gwen Kettenburg IDM Seminar Series
Presentation by: Gwen Kettenburg
Mon 12/2/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series

Recent Events

IDM Master's Defense

Chris Healy - MS Defense

Thursday 6/15 2:00PM - 4:00PM
Public Health Lecture Hall (A115)

Evaluation of a Novel Computationally Designed Prophylactic against Pandemic Influenza Virus in the Ferret Model 

Abstract: The Influenza virus is responsible for hundreds of thousands of deaths and millions of infections worldwide each year. In spite of the annual seasonal influenza vaccine and various therapeutics that currently exist, influenza currently poses a major health hazard to the world’s population. Vaccine efficacy is diminished due to the high mutation rate commonly exhibited by negative sense RNA viruses. This complicates the decision for which strains to include in the yearly vaccine, and often results in poorly matched vaccine and circulating strains. Antivirals are available to combat influenza infection, but are also becoming less effective due to the increasing development of anti-viral resistance and the limited selection. The development of improved vaccine strategies and novel antivirals are of critical importance to the public’s health and well being.  

Our research group has collaborated with researchers at the University of Washington in the evaluation of computationally designed influenza antiviral binder proteins.  These proteins bind to the viral hemagglutinin surface protein and mimic antibodies that are naturally elicited in vivo during influenza infection, prevents virus from binding and infecting cells by inhibiting the conformational change necessary for viral entry to host cells. Prior work evaluated viral protein binder HB36.6, demonstrating its efficacy against pandemic H1N1 in the ferret model.  The present thesis was designed to evaluate an improved, smaller mini-binder that is less toxic and more soluble in the ferret model.  Studies were designed to compare intranasal and intratracheal administration of mini-binder A13r33 24 hour prior to aerosol challenge with pandemic H1N1 in juvenile ferrets. Our working hypothesis was that the antiviral minibinder A13r33 would result in reduced infection as measured by improved clinical outcome and lower viral loads following virus challenge. Ferrets were monitored for 7 days post infection for clinical, viral and immunological parameters.  Results from these studies are presented in this thesis and provide compelling data for further evaluation of broadly protective novel therapeutics against influenza viruses.

Last Updated On Thursday, June 08, 2017 by Abby Kincaid
Created On Thursday, June 08, 2017

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