IDM Department News

Why a vaccine won’t end the covid pandemic

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TRIBUNE-REVIEW — IDM's Amy Hartman said the early results from vaccine trials have her feeling more optimistic than she’s been throughout the pandemic. But, she cautioned, “it’s important to keep in mind that vaccines aren’t necessarily a finite ‘solution’ but they are an important step toward controlling the pandemic.” In the meantime, continuing mitigation efforts—staying physically apart, wearing masks, and washing hands—remain vital.  

Q&A: Peter Salk on the Lessons Learned from Vaccine Development History

Peter Salk was 11 years old when a University of Pittsburgh team led by his father, the late Jonas Salk, created the inactivated poliovirus vaccine. The day of the 1955 announcement that the vaccine was safe, effective and potent, “everything just went crazy,” he recalls. “There were so many calls from reporters that we ended up having to get an answering service. Imagine how embarrassing that would be for a sixth grader.” Today, at 76, he’s bac... 

Egnot: 2020 Delta Omega Initiate

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"I utilize all aspects of my Pitt Public Health training in my current position. As a consultant, I often work on multidisciplinary teams to solve clients’ unique problems related to human health risk management. I am grateful for the diversity of coursework, training, and other applied opportunities afforded to me as a Pitt Public Health student, because I feel like those opportunities have allowed me to make meaningful contributions to the tea... 

Resciniti: 2020 Delta Omega Initiate

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Nicholas V. Resciniti received his MPH with a concentration in infectious disease management, intervention, and community practice from Pitt Public Health in 2016. Currently, he is pursing his PhD in epidemiology from the University of South Carolina, with his dissertation focusing on microbiome disruption and the longitudinal association with cognitive impairment and dementia. His research focus is related to understanding the biological underp... 

Sundermann: 2020 Delta Omega Initiate

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Alexander Sundermann is a clinical research coordinator and a DrPH student in epidemiology at Pitt Public Health. As a doctoral student and clinical research coordinator, Sundermann works in the Microbial Genomic Epidemiology Laboratory (MiGEL). He and the MiGEL team are working with experts at the University of Pittsburgh Medical Center (UPMC) and Carnegie Mellon University to build an Enhanced Detection System for Healthcare Associated Transmi... 

Drs. Dimitrov and Mellors progress in COVID-19 research using monoclonal antibody libraries

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TIMES OBSERVER - Pitt scientists have discovered the fastest way to identify potent, neutralizing human monoclonal antibodies against SARS-CoV-2. When Chinese scientists published the virus' genetic sequence January, Dimitrov’s team rapidly generated the virus’s receptor binding domain-part of the spike protein that attaches to human cells-and used it as “bait” to pan their multiple libraries of over 1 trillion human antibodies built over preced... 

HIV-related stigma in healthcare settings during COVID-19

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As part of the Conversations about COVID-19 seminar series, Mackey Friedman of IDM and BCHS joins IDM's Sarah Krier to discuss how the COVID-19 pandemic is affecting the lives of people living with HIV including their beliefs and attitudes about their healthcare needs and experiences.  

Reed explains what airborne virus means for reopening

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THE CONVERSATION - Respiratory scientist Douglas Reed, IDM and Pitt Med, examined studies that have shown how the virus has spread, including at a call center in South Korea, a restaurant in China, and a choir practice in Washington state. “The evidence strongly suggests that airborne transmission happens easily and is likely a significant driver of this pandemic. It must be taken seriously as people begin to venture back out into the world.”  

Mellors discusses potential COVID-19 drug

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CUMBERLAND TIMES-NEWS - IDM’s John Mellors, UPMC’s chief of infectious diseases, said the biological molecule “is small, which means it penetrates into areas of the body where a full-sized antibody may not. It’s fully human, meaning that there’s no foreign material that’s likely to be rejected by the host… and it appears to be safe.” But he added, it's too early to talk about pricing of a treatment when it’s not (tested) in humans yet.  

Summer of 2020: Evolution of our understanding of SARS-CoV-2 and ability to forecast COVID-19

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What we have learned during the summer of 2020 that puts SARS-CoV-2 into perspective with other emerging viruses and explores the current state of COVID-19 forecasting for the next few months. IDM's Amy Hartman talks what we know (and don't know) about SARS-CoV-2 and EPI's Donald Burke discusses the epidemiological and environmental factors that will shape the likely phases of the epidemic in our region.    

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Recent IDM Publications

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Rubio publishes thesis in Antimicrobial Agents and Therapy 

Rubio publishes thesis in Antimicrobial Agents and Therapy

Abigail Rubio (IDM '20) recently published In vitro Susceptibility of Multidrug-Resistant Pseudomonas aeruginosa following Treatment-emergent Resistance to Ceftolozane-tazobactam, comparing the in vitro susceptibility of multidrug-resistant Pseudomonas aeruginosa isolates 34 collected before and af... (04/20/2021)

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil 

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil

Multiple authors on behalf of the Microcephaly Epidemic Research Group, including IDM's Ernesto Marques, found the frequency of microcephaly in their results is consistent with previous studies. In addition, as children were evaluated at a later age and repeatedly by different groups of specialists... (03/19/2021)

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts 

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts

Amy L. Hartman, Sham Nambulli, Cynthia M. McMillen, Alexander G. White, Natasha Louise Tilston-Lunel, Joseph R. Albe, Emily Cottle, Matthew D. Dunn, L. James Frye, Theron H. Gilliland, Emily L. Olsen, Katherine J. O’Malley, Madeline M. Schwarz, Jaime A. Tomko, Reagan C. Walker, Mengying Xia, Matthe... (11/17/2020)

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function 

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function

Colleen R. Zaccard, Lauren Shapiro, Maria D. Martin-de-Saavedra, Christopher Pratt, Kristoffer Myczek, Amy Song, Marc P. Forrest, Peter Penzes Dendritic spinules are thin protrusions, formed by neuronal spines, not adequately resolved by diffraction-limited light microscopy, which has limit... (11/17/2020)
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Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States 

Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States

AIDS AND BEHAVIOR - Friedman, MR, Sang, JM, Bukowski, LA, Chandler, CJ, Egan, JE, Eaton, LA, Matthews, DD, Ho, K, Raymond, HF, & Stall, R. found that PrEP awareness campaigns tailored for black men who have sex with men and women (MSMW), concomitant with STI-to-PrEP interventions, will facilitate g... (10/14/2019)
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Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions 

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

JOURNAL OF VIROLOGY - Using samples from participants in the Multicenter AIDS Cohort study, Garcia-Bates, Palma, Shen, Gambotto, Macatangay, Ferris, Rinaldo, and Mailliard showed that PD-1 activation plays a positive role in initiating the primary T cell response. But later blocking of that pathway... (12/13/2018)

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)

IDM Videos

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Amanpour & Salk: Vaccine lessons from history (video) 

Amanpour & Salk: Vaccine lessons from history (video)

CNN — Christiane Amanpour discusses with IDM's Peter Salk the 97% drop in polio prevalence within a few years of initial vaccine adoption. In 1953, Dr. Peter Salk was one of the first to receive a polio vaccine—from none other than his father, Jonas Salk. They go on to discuss herd immunity and vac... (01/13/2021)
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"It's going to be a long road" - What IDM's Peter Salk thinks about COVID-19 

"It's going to be a long road" - What IDM's Peter Salk thinks about COVID-19

USA TODAY - Jonas Salk’s vaccine helped wipe polio from most of the world, something that many people hope will happen with the coronavirus vaccine. However, IDM's Dr. Peter Salk warns eradicating polio from the U.S. was a long and difficult journey, and he doesn’t expect eliminating COVID-19 will ... (12/29/2020)
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Biden coronavirus task force appointee Michael Osterholm discusses "The COVID Pandemic: The Evolving Reality" (video) 

Biden coronavirus task force appointee Michael Osterholm discusses "The COVID Pandemic: The Evolving Reality" (video)

In a special IDM Seminar, Michael T. Osterholm answers questions regarding the epidemiology of SARS-CoV-2 infection, public health strategies to reduce transmission, and thoughts on how the world will likely look one year from now. Osterholm was recently appointed to President-elect Biden's coronav... (12/17/2020)

Q&A: Peter Salk on the Lessons Learned from Vaccine Development History 

Q&A: Peter Salk on the Lessons Learned from Vaccine Development History

Peter Salk was 11 years old when a University of Pittsburgh team led by his father, the late Jonas Salk, created the inactivated poliovirus vaccine. The day of the 1955 announcement that the vaccine was safe, effective and potent, “everything just went crazy,” he recalls. “There were so many calls ... (11/17/2020)
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HIV-related stigma in healthcare settings during COVID-19 

HIV-related stigma in healthcare settings during COVID-19

As part of the Conversations about COVID-19 seminar series, Mackey Friedman of IDM and BCHS joins IDM's Sarah Krier to discuss how the COVID-19 pandemic is affecting the lives of people living with HIV including their beliefs and attitudes about their healthcare needs and experiences. (10/16/2020)
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