IDM Department News

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.   

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM interaction and downstream signaling cascades associated with synaptodendritic functions.   

In Harm’s Way: Women, HIV, Hep C, and Substance Use, hosted by MAAETC

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The MidAtlantic AIDS Education and Training Center hosted a conference that brought together regional experts to explore ways to increase awareness of the opioid and Hepatitis C epidemics affecting women and infants in Southwestern Pennsylvania. One outcome of note: they identified solutions to improve the current care model of clinical and behavioral health care for women of childbearing age who are opioid users.   

Bowling selected as grand award judge

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The 2018 grand award judge for the Intel International Science and Engineering Fair for the microbiology category is JENNIFER BOWLING (IDM ’21). The Intel International Science and Engineering Fair, is a Society for Science and the Public and is the world’s largest international pre-college science competition. Thousands of volunteers and judges are recruited for an education outreach day serving over 3,000 middle and high school students. 

Zaccard appointed chair of the Chicago Women in STEM Initiative

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To ensure the continuity of the Chicago Women in STEM and Academia Initiative, and represent postdoctoral women, Northwestern University welcomed IDM's COLLEEN ZACCARD to the Northwestern University Postdoctoral Forum (NUPF) Executive Board as the Chair of the Chicago Women in STEM Initiative.   

Rinaldo's former mentee develops novel technique to monitor anti-tumor T cells

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Pitt Medicine grad Kellie Smith leads a group at John's Hopkins that has developed a novel technique to detect and monitor anti-tumor T cells using a simple liquid biopsy approach. The technique is termed MANAFEST (mutation associated neoantigen functional expansion of specific T cells). Smith is an instructor of Oncology in the Bloomberg-Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins School of Medicine who worked with IDM chair ... 

Kujawa receives travel award to attend ASV 2018

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A $500 Student Travel Award has been awarded to MIKE KUJAWA (IDM '21) to attend the 37th Annual Meeting of the American Society for Virology. The conference is hosted by the University of Maryland and will take place July 14-18, 2018.  

Mailliard on how cells talk and help one another via tiny tube networks

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SCIENTIFIC AMERICAN - Working with dendrites, what he calls "the quarterbacks of the immune system," IDM's ROBBIE MAILLIARD and colleagues are applying the budding field of TNT research to HIV. Now, they are investigating whether drugs that are commonly used to lower cholesterol levels could be repurposed to control viral infections.   

Dean's Day 2018 IDM departmental award recipients

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Department of Infectious Diseases and Microbiology awards during our annual Dean's Day student research competition were given to KELSEY MESSERSCHMIDT (MPH '19), BETHANY FLAGE (MS '18), ROBERTA METTUS (MS '19), and RENEE ANDERKO (PhD '22).  

Dean's Day 2018 Master's Category Winners

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Congratulations to Dean's Day winners in the master's category. Receiving first place is VATSALA RANGACHAR (IDM '18). Second place was awarded to KELSEA LASORDA (EPI '18). Third place was given to HANNAH BITZER (BCHS '21).  

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Recent IDM Publications

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Rubio publishes thesis in Antimicrobial Agents and Therapy 

Rubio publishes thesis in Antimicrobial Agents and Therapy

Abigail Rubio (IDM '20) recently published In vitro Susceptibility of Multidrug-Resistant Pseudomonas aeruginosa following Treatment-emergent Resistance to Ceftolozane-tazobactam, comparing the in vitro susceptibility of multidrug-resistant Pseudomonas aeruginosa isolates 34 collected before and af... (04/20/2021)

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil 

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil

Multiple authors on behalf of the Microcephaly Epidemic Research Group, including IDM's Ernesto Marques, found the frequency of microcephaly in their results is consistent with previous studies. In addition, as children were evaluated at a later age and repeatedly by different groups of specialists... (03/19/2021)

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts 

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts

Amy L. Hartman, Sham Nambulli, Cynthia M. McMillen, Alexander G. White, Natasha Louise Tilston-Lunel, Joseph R. Albe, Emily Cottle, Matthew D. Dunn, L. James Frye, Theron H. Gilliland, Emily L. Olsen, Katherine J. O’Malley, Madeline M. Schwarz, Jaime A. Tomko, Reagan C. Walker, Mengying Xia, Matthe... (11/17/2020)

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function 

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function

Colleen R. Zaccard, Lauren Shapiro, Maria D. Martin-de-Saavedra, Christopher Pratt, Kristoffer Myczek, Amy Song, Marc P. Forrest, Peter Penzes Dendritic spinules are thin protrusions, formed by neuronal spines, not adequately resolved by diffraction-limited light microscopy, which has limit... (11/17/2020)
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Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States 

Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States

AIDS AND BEHAVIOR - Friedman, MR, Sang, JM, Bukowski, LA, Chandler, CJ, Egan, JE, Eaton, LA, Matthews, DD, Ho, K, Raymond, HF, & Stall, R. found that PrEP awareness campaigns tailored for black men who have sex with men and women (MSMW), concomitant with STI-to-PrEP interventions, will facilitate g... (10/14/2019)
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Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions 

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

JOURNAL OF VIROLOGY - Using samples from participants in the Multicenter AIDS Cohort study, Garcia-Bates, Palma, Shen, Gambotto, Macatangay, Ferris, Rinaldo, and Mailliard showed that PD-1 activation plays a positive role in initiating the primary T cell response. But later blocking of that pathway... (12/13/2018)

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)

IDM Videos

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Amanpour & Salk: Vaccine lessons from history (video) 

Amanpour & Salk: Vaccine lessons from history (video)

CNN — Christiane Amanpour discusses with IDM's Peter Salk the 97% drop in polio prevalence within a few years of initial vaccine adoption. In 1953, Dr. Peter Salk was one of the first to receive a polio vaccine—from none other than his father, Jonas Salk. They go on to discuss herd immunity and vac... (01/13/2021)
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"It's going to be a long road" - What IDM's Peter Salk thinks about COVID-19 

"It's going to be a long road" - What IDM's Peter Salk thinks about COVID-19

USA TODAY - Jonas Salk’s vaccine helped wipe polio from most of the world, something that many people hope will happen with the coronavirus vaccine. However, IDM's Dr. Peter Salk warns eradicating polio from the U.S. was a long and difficult journey, and he doesn’t expect eliminating COVID-19 will ... (12/29/2020)
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Biden coronavirus task force appointee Michael Osterholm discusses "The COVID Pandemic: The Evolving Reality" (video) 

Biden coronavirus task force appointee Michael Osterholm discusses "The COVID Pandemic: The Evolving Reality" (video)

In a special IDM Seminar, Michael T. Osterholm answers questions regarding the epidemiology of SARS-CoV-2 infection, public health strategies to reduce transmission, and thoughts on how the world will likely look one year from now. Osterholm was recently appointed to President-elect Biden's coronav... (12/17/2020)

Q&A: Peter Salk on the Lessons Learned from Vaccine Development History 

Q&A: Peter Salk on the Lessons Learned from Vaccine Development History

Peter Salk was 11 years old when a University of Pittsburgh team led by his father, the late Jonas Salk, created the inactivated poliovirus vaccine. The day of the 1955 announcement that the vaccine was safe, effective and potent, “everything just went crazy,” he recalls. “There were so many calls ... (11/17/2020)
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HIV-related stigma in healthcare settings during COVID-19 

HIV-related stigma in healthcare settings during COVID-19

As part of the Conversations about COVID-19 seminar series, Mackey Friedman of IDM and BCHS joins IDM's Sarah Krier to discuss how the COVID-19 pandemic is affecting the lives of people living with HIV including their beliefs and attitudes about their healthcare needs and experiences. (10/16/2020)
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