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IDM's Mellors finds latent HIV may exist in both resting and non-resting CD4 T cells

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INFECTIOUS DISEASE ADVISOR - Work of study co-author and IDM professor JOHN MELLORS reported that different clonal virus populations can be recovered from the two cell types. The findings suggest that inducible virus production may be a good marker of the latent infectious reservoir in both cell types. Identifying the sources of latent HIV and developing tools to measure improvements in therapies are essential for clinicians and their patients. 

Salk's son: Eradication of polio would make Pittsburgh proud

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TRIBLIVE - “The eradication of polio has been tantalizingly close for years now,” said Dean DONALD BURKE.... IDM visiting professor PETER SALK adds, “When polio is ultimately eradicated, it will be something the University of Pittsburgh and Pittsburghers in general can be proud of. The University played a major role in something that will be earthshaking.” Before that milestone is achieved, Jonas Salk's injectable form of the vaccine must be ... 

Ernesto Marques on how the response to Zika failed millions

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NEW YORK TIMES - Infectious disease specialist with IDM and at the Oswaldo Cruz Foundation in Brazil, ERNESTO MARQUES JR. said Brazilian scientists felt let down when they looked for outside help—at first from European donors and health agencies. “The local researchers’ role was mainly to collect samples,” Marques said bitterly.  

The Opioid Epidemic and a Long Overdue Response

Associate Professor Linda Frank takes thoughtful look at responses to opioid epidemic. From our department and Pitt Public Health there can be many actions that can be taken. 

Microcephaly Found in Babies of Zika-Infected Mothers Months After Birth

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NEW YORK TIMES - Dr. Ernesto T. A. Marques Jr., an infectious disease specialist at the University of Pittsburgh and the Oswaldo Cruz Foundation in Recife, who was not involved in either study, said it could be that because of the initial fetal brain damage, “the necessary pathways and hormones that organize growth of the neonatal brain are not there anymore and the brain doesn’t grow.” 

Pitt Public Health-led study finds HIV-positive men at higher risk of developing heart disease indicator

Men with HIV were at significantly higher risk for development of coronary artery calcium (CAC), an early sign of coronary heart disease, according to a large national study led by the University of Pittsburgh Graduate School of Public Health. In addition, the study identified two modifiable risk factors independently associated with increased incidence of CAC: smoking and increased insulin resistance. The results are published in the journal  A... 

Lawrence A. Kingsley: HIV-positive men at higher risk of developing heart disease indicator

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Men with HIV were at significantly higher risk for development of coronary artery calcium (CAC), an early sign of coronary heart disease, according to a large national study led by the  University of Pittsburgh Graduate School of Public Health . In addition, the study identified two modifiable risk factors independently associated with increased incidence of CAC: smoking and increased insulin resistance. “Taken together, these findings underscor... 

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Recent IDM Publications

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Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States 

Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States

AIDS AND BEHAVIOR - Friedman, MR, Sang, JM, Bukowski, LA, Chandler, CJ, Egan, JE, Eaton, LA, Matthews, DD, Ho, K, Raymond, HF, & Stall, R. found that PrEP awareness campaigns tailored for black men who have sex with men and women (MSMW), concomitant with STI-to-PrEP interventions, will facilitate g... (10/14/2019)
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Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions 

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

JOURNAL OF VIROLOGY - Using samples from participants in the Multicenter AIDS Cohort study, Garcia-Bates, Palma, Shen, Gambotto, Macatangay, Ferris, Rinaldo, and Mailliard showed that PD-1 activation plays a positive role in initiating the primary T cell response. But later blocking of that pathway... (12/13/2018)

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)

Zika virus displacement by a chikungunya outbreak in Recife, Brazil 

Zika virus displacement by a chikungunya outbreak in Recife, Brazil

PUBLIC LIBRARY OF SCIENCE - Magalhaes, Braga, Cordeiro, Oliveira, Castanha, Maciel, Amancio, Gouveia, Peixoto-deSilva Jr., Peixoto, Britto, Lima, Lima, and Marques detected the tail end of a Zika epidemic in 2015-16 which was displaced by a chikungunya epidemic. Few dengue cases were identified des... (06/14/2018)

Rift Valley fever in animals and humans: Current perspectives 

Rift Valley fever in animals and humans: Current perspectives

ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease. (06/11/2018)

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN 

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.  (05/18/2018)

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury 

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM in... (05/18/2018)