IDM Faculty News

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Stall’s research helps to “Kick ASS”

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SAN FRANCISCO BAY TIMES - The reality of AIDS Survivor Syndrome (ASS) is now being confirmed by empirical research. On November 3, 2017, BCHS Associate Chair for Science RON STALL presented his findings on the subject in San Francisco at a provider and community town hall entitled “Research on the AIDS Survivor Syndrome: New Data from The Multi-Center AIDS Cohort Study and Voices of Survivors Themselves.”  

Marques: While Zika hasn’t been in the news much, that doesn’t mean it’s gone

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WASHINGTON POST - Local transmission seems to have come to a standstill, with one suspected case in Texas and one case confirmed in Florida. Herd immunity may be preventing more big outbreaks. But if Zika behaves like other arboviruses, it will probably stick around. They tend to be cyclical, says Pitt Public Health researcher ERNESTO MARQUES. “You have big booms, then they drop. Then a few years later, they come back again.” 

Enigma: Marques worked to pinpoint culprit of mysterious illness in Brazil

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PITTWIRE - When a mysterious illness suddenly emerged in his Brazilian hometown, IDM researcher ERNESTO MARQUES mobilized with colleagues to decode its unknowns. The work may help infectious-disease researchers stop or stall new epidemics. His story begins on page 18. 

Frank on Telehealth Appalachian AIDS Education and Training (video)

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The Telehealth Appalachian AIDS Education and Training Center Project, led by IDM's LINDA FRANK, provides web-based HIV education, training, clinical guidelines, and resources to Appalachian community health centers. Frank has worked to increase knowledge and awareness about HIV disease in underserved communities in the hope of preventing discrimination and delivering more care to those who need it.  

Marques: Zika virus still offers no clear answers

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THE GLOBE AND MAIL - It has been two years since Brazil’s northeast was hit with the public-health crisis that left babies born with CZS and set off alarm bells in the global health community. Yet experts continue to grapple with big questions. “We can’t really tell if what happened here was replicated or not in other areas of Brazil or Latin America because we don’t really know how many women were exposed,” said IDM’s ERNESTO MARQUES, who is con... 

Frank addresses surgeon general report on opioid epidemic (video)

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WPXI - "We've got to increase public health awareness of addiction. A lot of people think, 'It's not my family, it's not me, it's not my community,' and we know that it can be anybody." IDM's LINDA FRANK talks to NIGHTTalk about opioid addiction in Pittsburgh and around the country.  

2017 faculty and staff Delta Omega initiates

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The following four individuals will be inducted into the Omicron chapter of the Delta Omega Honorary Society at the Graduate School of Public Health, recognizing merit and encouraging further excellence in, and devotion to, public health work: Nancy W. Glynn (EPI '94), faculty and alumna; Leah M. Lamonte (IDM '06), alumna; Natalie A. Solomon-Brimage (BCHS '06), alumna; Christopher A. Taylor (EPI '10), alumnus. 

Rotarian director talks with Salk and Burke about polio eradication (video)

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A round-table was held today with some amazing minds on the issue of polio eradication: Jennifer Jones, director of Rotary International; PETER SALK, IDM visiting professor and son of research pioneer Jonas Salk; and DONALD BURKE, school dean and University associate vice chancellor of global health. Rotary has been raising awareness that "We are this close to ending polio!" While all were in Pittsburgh, they shared amazing conversation about the... 

IDM's Peter Salk on importance of Julius Youngner, polio vaccine pioneer, dead at 96

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NEW YORK TIMES - “I think it’s absolutely fair to say that had it not been for Dr. Youngner, the polio vaccine would not have come into existence,” PETER SALK president of the Jonas Salk Legacy Foundation and a visiting professor at the University of Pittsburgh Graduate School of Public Health, said in an e-mail. He added, “The really important thing to recognize is that the development of the polio vaccine at the University of Pittsburgh was a t... 

Marques offers insignt as Zika season approaches

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TRIB LIVE - In the U.S., there have been 5,264 Zika cases reported, with the vast majority in travelers returning from affected areas in other countries, says ERNESTO MARQUES, associate professor with Pitt Public Health and scientific director of CURA ZIKA, an international alliance with counterparts in Brazil to help fundraising for research into the virus. Learn more about Cura Zika at www.publichealth.pitt.edu/curazika. 

Marques looks for clues to Zika damage in twins

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NEW YORK TIMES - Determining why one twin becomes infected in the womb while the other does not may illuminate how Zika crosses the placenta, how it enters the brain, and whether any genetic mutations make a fetus more resistant or susceptible to Zika infection. Perhaps the virus entered through a weak spot in one placenta’s membrane, said ERNESTO MARQUES, an infectious disease expert at Pitt Public Health and the Oswaldo Cruz Foundation in Recif... 

Study by IDM's Mellors provides new understanding of HIV infections

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A new study represents an important advance toward better treatments and even a cure. “The immune system stays activated, angry, upset and inflamed despite current treatments, and that’s not good,” said study leader JOHN MELLORS of infectious diseases and microbiology. The research, involving various research centers including the National Institute of Allergy and Infectious Diseases, counters the idea “that inflammation and immune-cell activati... 

DC alumni reception brings together friends and colleagues

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Dozens of Pitt Public Health grads from the capital area gathered at Penn Social during the 2017 ASPPH annual meeting, joining Dean Burke and host faculty for hearty conversations and refreshments. If the forecast of snow scared you away, we missed you! Access our photo albums anytime at www.publichealth.pitt.edu/flickr. 

IDM's Ernesto Marques knows Brazil's Zika families suffer a life of struggle and scares

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NEW YORK TIMES - In the impoverished northeast, devoted parents live around the needs of children whose grave disabilities are only beginning to be understood. “These babies, most of them or all of them, they’re going to live very long lives, you can keep them alive a long time, and they will need assistance from someone 24 hours a day,” said ERNESTO MARQUES, an infectious disease expert at the University of Pittsburgh and the Oswaldo Cruz Founda... 

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Recent IDM Publications

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Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States 

Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States

AIDS AND BEHAVIOR - Friedman, MR, Sang, JM, Bukowski, LA, Chandler, CJ, Egan, JE, Eaton, LA, Matthews, DD, Ho, K, Raymond, HF, & Stall, R. found that PrEP awareness campaigns tailored for black men who have sex with men and women (MSMW), concomitant with STI-to-PrEP interventions, will facilitate g... (10/14/2019)
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Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions 

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

JOURNAL OF VIROLOGY - Using samples from participants in the Multicenter AIDS Cohort study, Garcia-Bates, Palma, Shen, Gambotto, Macatangay, Ferris, Rinaldo, and Mailliard showed that PD-1 activation plays a positive role in initiating the primary T cell response. But later blocking of that pathway... (12/13/2018)

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)

Zika virus displacement by a chikungunya outbreak in Recife, Brazil 

Zika virus displacement by a chikungunya outbreak in Recife, Brazil

PUBLIC LIBRARY OF SCIENCE - Magalhaes, Braga, Cordeiro, Oliveira, Castanha, Maciel, Amancio, Gouveia, Peixoto-deSilva Jr., Peixoto, Britto, Lima, Lima, and Marques detected the tail end of a Zika epidemic in 2015-16 which was displaced by a chikungunya epidemic. Few dengue cases were identified des... (06/14/2018)

Rift Valley fever in animals and humans: Current perspectives 

Rift Valley fever in animals and humans: Current perspectives

ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease. (06/11/2018)

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN 

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.  (05/18/2018)

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury 

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM in... (05/18/2018)