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COVID-19 Update: As Pa. cases decline, did state avoid post-holiday surge?

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PITTSBURGH POST-GAZETTE — Lee Harrison, a Pitt epidemiologist and chairman of the Allegheny County Board of Health, said that the drop in the positivity rate was encouraging, but warned that the state is not done with the winter surge. “We’re in the middle still of a raging pandemic,” he said.  "I would encourage people to really continue to hunker down, stay safe, and, whenever their turn comes up to get vaccinated, get vaccinated.”  

Amanpour & Salk: Vaccine lessons from history (video)

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CNN — Christiane Amanpour discusses with IDM's Peter Salk the 97% drop in polio prevalence within a few years of initial vaccine adoption. In 1953, Dr. Peter Salk was one of the first to receive a polio vaccine—from none other than his father, Jonas Salk. They go on to discuss herd immunity and vaccine hesitancy both in 1954 and today.  

From polio to the COVID vaccine, IDM's Peter Salk sees great progress

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NPR - IDM's Peter Salk was just 9 when he got one of the first polio vaccine shots in 1953 at the family home outside Pittsburgh. Today, he has been hugely impressed by the development of a vaccine in less than a year. Dr. Salk is a bit concerned about the number of people who are reluctant, or outright opposed, to getting the vaccine. But he believes those numbers will shrink as people see the benefits. Until then, he'll be playing it safe.   

Covid-19 vaccine: Light faint at the end of the tunnel for Vietnam

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VNEXPRESS - Amid a global sigh of relief over vaccine developments, experts say Vietnam's access is fraught with uncertainty. IDM's Toan Ha said the country's ability to produce its own vaccines is critical. "I believe that Vietnam will be able to successfully develop clinically-tested Covid-19 vaccines in the near future. It is better to be self-reliant, being able to locally produce an affordable and safe vaccine than relying on foreign manufa... 

"It's going to be a long road" - What IDM's Peter Salk thinks about COVID-19

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USA TODAY - Jonas Salk’s vaccine helped wipe polio from most of the world, something that many people hope will happen with the coronavirus vaccine. However, IDM's Dr. Peter Salk warns eradicating polio from the U.S. was a long and difficult journey, and he doesn’t expect eliminating COVID-19 will be any easier. “It’s going to be a long road, just even getting enough vaccines out to people around the world."  

White House bet on Pfizer doses raises concerns about vaccine supply

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THE HILL - The Trump administration's decision not to purchase additional doses of Pfizer's COVID-19 vaccine could prove to be a risky gamble resulting in vaccination delays. IDM's Amy Hartman said it appeared that the administration was hedging its bets. "I think it's easy in hindsight to say yeah, they should have [secured more doses]." But Hartman was not sure why the U.S. would decline to buy more doses once they knew initial results wer... 

On World AIDS Day 2020, Learn About Pitt’s Work and Impact

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PITTWIRE - Pitt Public Health, the local community, and the University of Pittsburgh have long fought HIV and AIDS. One of our many efforts is the Pitt Men’s Study, which last year celebrated a milestone: 40 years of studying the disease. Learn how we're working together to conquer the disease.  

As the battle against HIV continues, Pitt Men’s Study volunteer joins coronavirus vaccine study

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TRIBUNE-REVIEW — When drug makers solicited volunteers to test a coronavirus vaccine, Marc Wagner jumped. It was a matter of giving back. Wagner felt compelled to do his part for science. But just as important, it was an opportunity for him to honor the herculean efforts of scientists and others he has met over the last 35 years in his battle against HIV.  

Why a vaccine won’t end the covid pandemic

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TRIBUNE-REVIEW — IDM's Amy Hartman said the early results from vaccine trials have her feeling more optimistic than she’s been throughout the pandemic. But, she cautioned, “it’s important to keep in mind that vaccines aren’t necessarily a finite ‘solution’ but they are an important step toward controlling the pandemic.” In the meantime, continuing mitigation efforts—staying physically apart, wearing masks, and washing hands—remain vital.  

Emergency use of COVID-19 vaccines likely in weeks, though U.S. still headed for a harsh winter

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MILWAUKEE JOURNAL SENTINEL - "Vaccination of select high-risk individuals may start by the end of the year, but most likely the majority of vaccines will be released during the first quarter of 2021," said IDM's Amy Hartman. Vaccine makers still need to gather results from larger groups of recipients who have been studied for longer periods. "That's important," she said, "because some very rare side effects may not become apparent until either a... 

Drs. Dimitrov and Mellors progress in COVID-19 research using monoclonal antibody libraries

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TIMES OBSERVER - Pitt scientists have discovered the fastest way to identify potent, neutralizing human monoclonal antibodies against SARS-CoV-2. When Chinese scientists published the virus' genetic sequence January, Dimitrov’s team rapidly generated the virus’s receptor binding domain-part of the spike protein that attaches to human cells-and used it as “bait” to pan their multiple libraries of over 1 trillion human antibodies built over preced... 

HIV-related stigma in healthcare settings during COVID-19

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As part of the Conversations about COVID-19 seminar series, Mackey Friedman of IDM and BCHS joins IDM's Sarah Krier to discuss how the COVID-19 pandemic is affecting the lives of people living with HIV including their beliefs and attitudes about their healthcare needs and experiences.  

Reed explains what airborne virus means for reopening

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THE CONVERSATION - Respiratory scientist Douglas Reed, IDM and Pitt Med, examined studies that have shown how the virus has spread, including at a call center in South Korea, a restaurant in China, and a choir practice in Washington state. “The evidence strongly suggests that airborne transmission happens easily and is likely a significant driver of this pandemic. It must be taken seriously as people begin to venture back out into the world.”  

Mellors discusses potential COVID-19 drug

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CUMBERLAND TIMES-NEWS - IDM’s John Mellors, UPMC’s chief of infectious diseases, said the biological molecule “is small, which means it penetrates into areas of the body where a full-sized antibody may not. It’s fully human, meaning that there’s no foreign material that’s likely to be rejected by the host… and it appears to be safe.” But he added, it's too early to talk about pricing of a treatment when it’s not (tested) in humans yet.  

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Recent IDM Publications

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Rubio publishes thesis in Antimicrobial Agents and Therapy 

Rubio publishes thesis in Antimicrobial Agents and Therapy

Abigail Rubio (IDM '20) recently published In vitro Susceptibility of Multidrug-Resistant Pseudomonas aeruginosa following Treatment-emergent Resistance to Ceftolozane-tazobactam, comparing the in vitro susceptibility of multidrug-resistant Pseudomonas aeruginosa isolates 34 collected before and af... (04/20/2021)

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil 

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil

Multiple authors on behalf of the Microcephaly Epidemic Research Group, including IDM's Ernesto Marques, found the frequency of microcephaly in their results is consistent with previous studies. In addition, as children were evaluated at a later age and repeatedly by different groups of specialists... (03/19/2021)

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts 

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts

Amy L. Hartman, Sham Nambulli, Cynthia M. McMillen, Alexander G. White, Natasha Louise Tilston-Lunel, Joseph R. Albe, Emily Cottle, Matthew D. Dunn, L. James Frye, Theron H. Gilliland, Emily L. Olsen, Katherine J. O’Malley, Madeline M. Schwarz, Jaime A. Tomko, Reagan C. Walker, Mengying Xia, Matthe... (11/17/2020)

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function 

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function

Colleen R. Zaccard, Lauren Shapiro, Maria D. Martin-de-Saavedra, Christopher Pratt, Kristoffer Myczek, Amy Song, Marc P. Forrest, Peter Penzes Dendritic spinules are thin protrusions, formed by neuronal spines, not adequately resolved by diffraction-limited light microscopy, which has limit... (11/17/2020)
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Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States 

Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States

AIDS AND BEHAVIOR - Friedman, MR, Sang, JM, Bukowski, LA, Chandler, CJ, Egan, JE, Eaton, LA, Matthews, DD, Ho, K, Raymond, HF, & Stall, R. found that PrEP awareness campaigns tailored for black men who have sex with men and women (MSMW), concomitant with STI-to-PrEP interventions, will facilitate g... (10/14/2019)
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Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions 

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

JOURNAL OF VIROLOGY - Using samples from participants in the Multicenter AIDS Cohort study, Garcia-Bates, Palma, Shen, Gambotto, Macatangay, Ferris, Rinaldo, and Mailliard showed that PD-1 activation plays a positive role in initiating the primary T cell response. But later blocking of that pathway... (12/13/2018)

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)