IDM PhD & MS Journal Club

Jennifer Bowling, PhD Student / Reed Lab

Wednesday 2/1 12:00PM - 1:00PM
A719 Public Health
B.A. Satterfield, R.W. Cross, K.A. Fenton, et al.  Nipah Virus C and W Proteins Contribute to Respiratory Disease in Ferrets.  J. Virol.  90:6326, 2017.
Nipah virus (NiV) is a highly lethal paramyxovirus that recently emerged as a causative agent of febrile encephalitis and severe respiratory disease in humans. The ferret model has emerged as the preferred small-animal model with which to study NiV disease, but much is still unknown about the viral determinants of NiV pathogenesis, including the contribution of the C protein in ferrets. Additionally, studies have yet to examine the synergistic effects of the various P gene products on pathogenesis in animal models. Using recombinant NiVs (rNiVs), we examine the sole contribution of the NiV C protein and the combined contributions of the C and W proteins in the ferret model of NiV pathogenesis. We show that an rNiV void of C expression resulted in 100% mortality, though with limited respiratory disease, like our previously reported rNiV void of W expression; this finding is in stark contrast to the attenuated phenotype observed in previous hamster studies utilizing rNiVs void of C expression. We also observed that an rNiV void of both C and W expression resulted in limited respiratory disease; however, there was severe neurological disease leading to 60% mortality, and the surviving ferrets demonstrated sequelae similar to those for human survivors of NiV encephalitis.

Last Updated On Wednesday, February 1, 2017 by Malenka, Judith Ann
Created On Tuesday, January 3, 2017