- F. Gally, Y.P. Di, S. K. Smith, M. N. Minor, Y. Liu, D. L Bratton, S. C. Frasch, N. M. Michels, S. R. Case and H.W. Chu. SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice. American Journal of Pathology 178(5):2159-67. May, 2011. PMID:21514430
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- G. D. Leikauf, V. J. Concel, P. Liu, A. Berndt, A. S. Jang, K. Bein, K. A. Brant, M. Dietsch, H. Pope-Varsalona, R. A. Dopico, Jr., Y.P. Di, Q. Li, L. J. Vuga, M. Medvedovic, N. Kaminski, M. You, D. Prows. Haplotype association mapping of survival during acute lung injury in mice implicates transforming growth factor beta signaling. American Journal of Respiratory and Critical Care Medicine 183(11):1499-509. Jun 1, 2011, Epub 2011 Feb 4, PMID:21297076
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- L. Lukinskiene, S. Reynolds, C. Steele, B. Stripp, G.Leikauf, J. Kolls, and Y.P. Di. Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection. Journal of Immunology, 187(1):382-90. Jul 1, 2011, Epub 2011 Jun 1. PMID:21632717
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- N Vo, D Wang, G Sowa, W Witt, K Ngo, P Coelho, R Bedison, B Byer, R Studer, J Lee, Y.P. Di, and J Kang. Differential effects of nicotine and tobacco smoke condensate on human annulus fibrosus cell metabolism. Journal of Orthopaedic Research 2011 Mar 29. doi: 10.1002/jor.21417. [Epub ahead of print] PMID:21448984
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- Y.P. Di. Functional roles of SPLUNC1 in innate immune response against gram-negative bacteria. Biochemical Society Transactions 2011 Aug 1;39(4):1051-5 PMID:21787346
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- P. Keohavong, B. Kahkonon, E. Kinchington, J. Yin, X. Liu, J. Jin, J. M. Siegfried and Y.P. Di. K-ras mutations in lung tumors from NNK-treated mice with lipopolysaccharide-elicited lung inflammation. Anticancer Research 2011 Sep;31(9):2877-82) PMID:21868532
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- T. Richards, C. Park, Y. Chen, K. F. Gibson, Y. P. Di, A. Pardo, S. Watkins5, M. Selman, J. Pilewski, F. Sciurba, N. Kaminski, Y. Zhang. Allele Specific Transactivation of Matrix Metalloproteinase 7 by FoxA2 and Correlation with Plasma Levels in Idiopathic Pulmonary Fibrosis. American Journal of Physiology. Lung Cellular and Molecular Physiology 2012 Apr; 302(8):L746-54. Epub 2012 Jan 20. PMID: 22268124
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- S. Tao, L. Zhu, P. Lee, W. Lee, , K. Knox, J. Chen, Y. P. Di and Yin Chen. Negative control of TLR3 signaling by TICAM1 downregulation. American Journal of Respiratory Cell and Molecular Biology 2012 May; 46(5):660-7. Epub 2011 Dec 28. PMID: 22205631
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- G.D. Leikauf, H. Pope-Varsalona, V.J. Concel, P. Liu, K. Bein, A. Berndt, T.M. Martin, K. Ganguly, A.S. Jang, K.A. Brant, R.A. Dopico Jr, S. Upadhyay, Y. P. Di, Q. Li, Z. Hu, L.J. Vuga, M. Medvedovic, N. Kaminski, M. You, D.C. Alexander, J.E. McDunn, D.R. Prows, D.L. Knoell, J.P. Fabisiak. Integrative assessment of chlorine-Induced acute lung injury in mice American Journal of Respiratory Cell and Molecular Biology 2012 Mar 23. [Epub ahead of print] PMID: 22447970
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- J.V. Thaikoottathil, R.J. Martin, Y. P. Di, M. Minor, S. Case, B. Zhang, G. Zhang, H. Huang, H.W. Chu. SPLUNC1 Deficiency Enhances Airway Eosinophilic Inflammation in Mice. American Journal of Respiratory Cell and Molecular Biology 2012 Apr 12. [Epub ahead of print] PMID: 22499853
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- R. Birru, B, Kahkonon, and Y. P. Di. Chronic Inflammation in the Pathogenesis of COPD and Lung Cancer. Proceedings of the American Thoracic Society 2012 May; 9(2):81. PMID: 22550252
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- Y. P. Di, J. Zhao, and R. Harper. Cigarette smoke induces MUC5AC expression through the activation of Sp1. Journal of Biological Chemistry 2012 Aug 10;287(33):27948-58. Epub 2012 Jun 14. PMID: 22700966
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- Y. Liu and Y. P. Di. Effects of second hand smoke on airway secretion and mucociliary clearance. Frontiers in Physiology 3:342. doi: 10.3389/fphys.2012.00342, PMID: 22973232 IF=4.13
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- R. Birru, and Y. P. Di. Pathogenic mechanism of lung diseases associated with cigarette smoke induced inflammation. Frontiers in Physiology 3:348. doi: 10.3389/fphys.2012.00348, PMID: 22973236
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- S. Sayeed, L. Nistico, C. St Croix, and Y. P. Di. Multifunctional role of human SPLUNC1 in Pseudomonas aeruginosa infection. Infection And Immunity 2013 Jan; 81(1):285-91. doi: 10.1128/IAI.00500-12. Epub 2012 Nov 6.PMID: 23132494
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- Y. Liu, J. A. Bartlett, M. E. Di, J. M. Bomberger, Y. R. Chan, L. Gakhar, R. K. Mallampalli, P. B. McCray, Jr., and Y. P. Di. SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection. American Journal of Pathology 2013 May;182(5):1519-31. doi: 10.1016/j.ajpath.2013.01.050..PMID: 23499554
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- G.D. Leikauf, V.J. Concel, K. Bein, P. Liu, A. Berndt, T.M. Martin, K. Ganguly, A.S. Jang, K.A. Brant, R.A. Dopico Jr, S. Upadhyay, C.L. Cario, Y. P. Di, L.J. Vuga, E. Kostem, E. Eskin, M. You, N. Kaminski, D..R Prows, D.L. Knoell, J.P. Fabisiak. Functional Genomic Assessment of Phosgene-induced Acute Lung Injury in Mice. American Journal of Respiratory Cell and Molecular Biology 2013 Apr 5. [Epub ahead of print] PMID: 23590305
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- Volonte D, Liu Z, Musille PM, Stoppani E, Wakabayashi N, Y. P. Di, Lisanti MP, Kensler TW, Galbiati F. Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence. Molecular Biology of the Cell 2013 Jun;24(12):1852-62. doi: 10.1091/mbc.E12-09-0666. Epub 2013 May 1. PMID: 23637463
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- Y. P. Di, A. V. Tkach, N. Yanamala, S. Stanley, S Gao, M. R. Shurin, E. R Kisin, V. E. Kagan, A. Shvedova. Dual Acute Pro-Inflammatory and Anti-Fibrotic Pulmonary Effects of SPLUNC1 After Exposure to Carbon Nanotubes. American Journal of Respiratory Cell and Molecular Biology 2013 May 30. [Epub ahead of print] PMID: 23721177
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- Y. Liu, M. E. Di, H.W. Chu, X. Liu, L. Wang, S. Wenzel, and Y. P. Di. Increased susceptibility to pulmonary Pseudomonas infection in Splunc1 knockout mice. Journal of Immunology 2013 Oct 15;191(8):4259-4268. Epub 2013 Sep 18.PMID: 24048904
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- Y.P. Di. Assessment of pathological and physiological changes in mouse lung through bronchoalveolar lavage. Methods in Molecular Biology 2014;1105:33-42. doi: 10.1007/978-1-62703-739-6_3. PMID: 24623217
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- Y. Zhang, R Birru, and Y.P. Di. Analysis of clinical and biological samples using microsphere based multiplexing Luminex system. Methods in Molecular Biology 2014;1105:43-57. doi: 10.1007/978-1-62703-739-6_4. PMID: 24623218
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- L Zhu, Y.P. Di, R Wu, KE Pinkerton, Y Chen. Repression of CC16 by cigarette smoke (CS) exposure. PLOS One 2015 Jan 30;10(1):e0116159. doi: 10.1371/journal.pone. 0116159. eCollection 2015. PMID: 25635997
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- B Lee, KM Robinson, KJ McHugh, EV Scheller, S Mandalapu, C Chen, Y.P. Di, ME Clay, RI Enelow, PJ Dubin, JF Alcorn. Influenza-induced Type I Interferon Enhances Susceptibility to Gram-negative and Gram-positive Bacterial Pneumonia in Mice. American Journal of Physiology. Lung Cellular and Molecular Physiology 2015 May 22;ajplung.00338.2014. PMID:26001778. doi:10.1152/ajplung.00338.2014.
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- A. Di Grazia, F. Cappiello, H. Cohen, B Casciaro, V. Luca, A. Pini, Y.P. Di, Shai, and M.Mangoni. D-Amino acids incorporation in the frog skin-derived peptide esculentin-1a(1-21)NH2 is beneficial for its multiple functions. Amino Acids 2015 Dec;47(12):2505-19. doi: 10.1007/s00726-015-2041-y. PMID: 26162435
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- D. G. Phinney, M. Di Giuseppe, J. Njah, E. Sala, S. Shiva, C. M. St Croix, D. B. Stolz, S. C. Watkins, Y.P. Di, G. D. Leikauf, J. Kolls, D. W. Riches, G. Deiuliis, N. Kaminski, S. V Boregowda, D. H. McKenna, and L. A. Ortiz. Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle micro RNAs. Nature Communication 2015 Oct 7;6:8472. doi: 10.1038/ncomms9472. PMID: 26442449
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- E. Travanty, B. Zhou, H. Zhang, Y.P. Di, J. Alcorn, D. Wentworh, R. Mason, and J. Wang. Differential susceptibility of human lung primary cells to H1N1 influenza viruses. Journal of Virology 2015 Dec;89(23):11935-44. doi: 10.1128/JVI.01792-15. Epub 2015 Sep 16. PMID: 26378172
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- W.G Walton, S Ahmad, MS Little, CS Kim, J Tyrrell, Q Lin, Y.P. Di, R Tarran, MR Redinbo. Structural features essential to the antimicrobial functions of human SPLUNC1. Biochemistry 2016 May 31;55(21):2979-91. doi: 10.1021/acs.biochem.6b00271. Epub 2016 May 17. PMID: 27145151
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- F. Cappiello, A. Di Grazia, L. Segev-Zarko, S. Scali, L. Ferrera, L. Galietta, A. Pini, Y. Shai, Y. P. Di, and M. Mangoni. Esculentin-1a-derived peptides promote clearance of P. aeruginosa internalized in cystic fibrosis bronchial cells as well as lung cells migration: Biochemical properties and a plausible mode of action. Antimicrobial Agents and Chemotherapy 2016; 60(12):7252-7262. PMID: 27671059
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- T. Wu, J. Huang, P.J. Moore, M.R. Little, W.G. Walton, R.C. Fellner, N. E. Alexis, Y.P. Di, M.R. Redinbo, S.L. Tilley and R. Tarran. Identification of BPIFA1 as an epithelium-derived smooth muscle relaxing factor. Nature Communication 8, Published online: 06 February 2017 doi:10.1038/ncomms14118. PMID: 28165446
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- Y Chen, M. M. Vasquez, L. Zhu, R. E. Lizarraga, M. Krutzsch, J. Einspahr, D. S. Alberts, Y.P. Di, F. D. Martinez, and S. Guerra. Effects of retinoids on augmentation of club cell secretory protein. American Journal of Respiratory and Critical Care Medicine 2017 Feb 23. doi: 10.1164/rccm.201608-1611LE. PMID: 28231434
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- B. Deslouches and Y.P. Di. Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications. Oncotarget 2017 Mar 31. doi: 10.18632/oncotarget. 16743. PMID: 28422728, PMCID: PMC5542299
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- C. Chen, M. Mangoni, and Y.P. Di. In vivo therapeutic efficacy of frog skin-derived peptides against Pseudomonas aeruginosa-induced pulmonary infection. Scientific Reports 2017 Aug 17;7(1):8548. doi: 10.1038/s41598-017-08361-8. PMID: 28819175, PMCID: PMC5561116
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- K. Ngo, P. Pohl, D. Wang, A. Leme, J. Lee, Y.P. Di, P. Roughley, P.D. Robbins, L. Niedernhofer, G. Sowa, J. Kang, S. Shapiro and N.V. Vo. ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration. Spine (Phila Pa 1976). 2017 Oct 15;42(20):1521-1528. doi: 10.1097/BRS.0000000000002258. PMID: 28570296, PMCID: PMC5633483
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- B. Deslouches and Y.P. Di. Antimicrobial Peptides: A Potential Therapeutic Option for Surgical Site Infections. Clinics in Surgery 2017 Nov 2;1740: 1-4. NIHMS981044
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- E. Caves, R. Butch, S. Cook, L. Wasil, C. Chen, Y.P. Di, N. Lee, and K. Shair. Latent Membrane Protein 1 is a novel determinant of Epstein-Barr virus genome persistence and reactivation. mSphere 2017 Nov 8: 2 (6): e00453-17. PMID: 29134204, PMCID: PMC5677982
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- D. Volonte, A. Vyas, C. Chen, S. Dacic, L. Stabile, B. Kurland, S. Abberbock, T. Burns, J. Herman, Y.P. Di and F. Galbiati. Caveolin-1 promotes the tumor suppressor properties of oncogene-induced cellular senescence. Journal of Biological Chemistry 2018 Feb 2; 293(5):1794-1809. doi: 10.1074/jbc.M117.815902. Epub 2017 Dec 15.PMID: 29247004, PMCID: PMC5798308
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- C. Chen, B. Deslouches, R. Montelaro and Y.P. Di. Enhanced efficacy of the engineered antimicrobial peptide WLBU2 via direct airway delivery in a murine model of P. aeruginosa pneumonia. Clinical Microbiology and Infection 2018 May; 24(5):547.e1-547.e8. NIHMSID: NIHMS903948. PMID: 28882728, PMCID: PMC5835169
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- C. Chen, X Zhang, Q. Lin, N. Remlinger, T. Gilbert and Y.P. Di. Urinary bladder matrix protects host in a murine model of bacterial-induced lung infection. Tissue Engineering, Part A 2018 Jul 18; https://doi.org/10.1089/ten.TEA.2018.0080, DOI: 10.1089/ten.TEA.2018. 0080 PMID: 30019635
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- Z. Yu, B. Deslouches, W. G. Walton, M. R. Redinbo, and Y.P. Di. Enhanced biofilm prevention activity of a SPLUNC1-derived antimicrobial peptide against Staphylococcus aureus. PLOS ONE 2018 Sep 14; 13(9):e0203621. doi: 10.1371/journal.pone.0203621. eCollection 2018 PMID: 30216370, PMCID: PMC6138395
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- Q. Lin, B. Deslouches, RC. Montelaro and Y.P. Di. Prevention of ESKAPE pathogen biofilm formation by antimicrobial peptides WLBU2 and LL37. International Journal of Antimicrobial Agents 2018 Nov; 52(5):667-672. doi: 10.1016/j.ijantimicag.2018.04.019. PMID: 29753132, PMCID: PMC6230315
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- A. Kumagai, F. G. Dupuy, Z. Arsov, Y. Elhady, D. Moody, R. K. Ernst, B. Deslouches, R. C. Montelaro, Y. P. Di, and S. Tristram-Nagle. Elastic behavior of model membranes with antimicrobial peptides depends on lipid specificity and D-enantiomers. Soft Matter 2019 Jan 31; DOI: 10.1039/c8sm02180e, PMID: 30702120
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- S. Jiang, B. Deslouches, C. Chen, M. E. Di, and Y. P. Di. Antibacterial Properties and Efficacy of a Novel SPLUNC1-Derived Antimicrobial Peptide, α4-Short, in a Murine Model of Respiratory Infection. mBio 2019 Apr 9;10(2). pii: e00226-19. doi: 10.1128/mBio.00226-19. DOI: 10.1128/mBio.00226-19. PMID: 30967458
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- N. Schaefer, M. A. X. Li, Seibold, N. N. Jarjour, L. C. Denlinger, M. Castro, A. M. Coverstone, W. G. Teague, J. Boomer, E. R. Bleecker, D. A. Meyers, J. Fahy, B. R. Phillips, D. T. Mauger, A. Dakhama, S. Gellatly, R. Berman, Y. P. Di*, S. E. Wenzel*, and H. W. Chu* (*co-corresponding authors). The effect of SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelial cells. JCI Insight 2019 Apr 18;4(8). pii: 127237. doi: 10.1172/jci.insight.127237. eCollection 2019 Apr 18. PMID: 30996135
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- B. Casciaro, I. d'Angelo, X. Zhang, M. Loffredo, G. Conte, F. Cappiello, F. Quaglia, Fabiana; Y. P. Di, F. Ungaro, and M. Mangoni. Poly(lactide-co-glycolide) nanoparticles for prolonged therapeutic efficacy of esculentin-1a-derived antimicrobial peptides against Pseudomonas aeruginosa lung infection: in vitro and in vivo studies. Biomacromolecules 2019 Apr 23. doi: 10.1021/acs.biomac.8b01829. PMID: 31013061
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- B. Casciaro, Q. Lin, S. Afonin, M. R. Loffredo, V. de Turris, V. Middel, A. S. Ulrich, Y. P Di, and M. L. Mangoni. Inhibition of Pseudomonas aeruginosa biofilm formation and expression of virulence genes by selective epimerization in the peptide Esculentin‐1a(1‐21)NH2. The FEBS Journal 2019 May 30. doi: 10.1111/febs.14940. PMID: 31144441
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- Z. Li, M. Zeng, Y. Deng, J. Zhao, X. Zhou, J.B. Trudeau, E. Goldschmidt, J.A. Moore, H. Chu, W. Zhang, S. Yin, Z. Liu, Y. P. Di, S.E. Lee, S.E. Wenzel. Nasal polyps 15-lipoxygenase 1 promotes CCL26/Eotaxin3 expression through ERK activation. Journal of Allergy and Clinical Immunology 2019 Jul 10. pii: S0091-6749(19)30905-4. doi: 10.1016/j.jaci.2019. 06.037. [Epub ahead of print] PMID: 31301373
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- B. Mashbat, E. Bellos, S. Hodeib, F Bidmos, R. S. Thwaites, Y. Lu, V. Wright, J. Herberg, D. S. Klobassa, W. Zenz, T. Hansel, S. Nadel, P. R. Langford, L. J. Schlapbach, M. Li, M. Redinbo, Y. P. Di, M. Levin and V. Sancho-Shimizu. A rare mutation in SPLUNC1 underlies meningococcal disease affecting bacterial adherence and invasion. Clinical Infectious Diseases (In Press) doi: 10.1093/cid/ciz600
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