Udai B Pandey, PhD

Associate Professor, Human Genetics


4401 Penn Ave, Rangos Research Building, 7121, Pittsburgh, PA 15224
R-znvy: hqnv@cvgg.rqh
Primary Phone: 967-147-8647
Web site:


  • 1999-2004  PhD (Medical Genetics), Sanjay Gandhi Postgraduate Institute of Medical Sciences, India
  • 2004-2008 Postdoctoral fellow, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia (J. Paul Taylor’s lab)
  • 2008-2009 Postdoctoral fellow, Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis TN (J. Paul Taylor’s lab)


  • Genetics Society of America
  • Society for Neuroscience


  • Louisiana State University Health Sciences Center Alumni Excellence Award  (2013)
  • Faculty Assembly Award for Outstanding Accomplishments by a Young Faculty Member at Louisiana State University Health Sciences Center (2012)
  • The Board of Reagents (State of Louisiana) Travel Grant for Emerging Faculty (TGEF) (2011)
  • Travel Award, Gordon Research Conference on CAG Triplet Repeat Disorders, France, (2007)
  • Best Poster Award, Annual Neurodegeneration Retreat, University of Pennsylvania (2007)
  • Selected for platform presentation, 49th Annual Drosophila Research Conference, Philadelphia (2007)
  • Travel award, Keystone Symposia, Molecular Mechanisms of Neurodegeneration, New Mexico, (2007)
  • Best poster Award, Annual Biomedical Postdoc Research Symposium, University of Pennsylvania (2007)
  • Young Investigator travel award, Gordon Research Conference, CAG Repeat Disorders, Boston (2005)
  • Best poster Award, Annual Biomedical Postdoc Research Symposium, University of Pennsylvania (2005)
  • Best Poster Award, Annual Neurodegeneration Retreat, University of Pennsylvania (2005)

Selected Publications

  •    Anderson A, Gochenaur L, Singh A, Grant R, Patel K, Watkins S, Wu J, Pandey UB. Traumatic injury induces Stress Granule Formation and enhances Motor Dysfunctions in ALS
    Models. Hum Mol Genet. 2018 Apr 15;27(8):1366-1381.
  • Bakthavachalu B, Huelsmeier J, Sudhakaran I, Hillebrand J, Singh A, Petrauskas A, Thiagarajan D, Sankaranarayanan M, Mizoe L, Anderson EA, Pandey UB, Ross E,
    VijayRaghavan K, Parker R, Ramaswami M. RNP-granules assembly via Ataxin02
    disordered domains is required for long-term memory and neurodegeneration. Neuron. 2018 May 16;98(4):754-766
    *Previewed in ‘Neuron’
  • Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM,
    Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell
    CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 2018 Apr 19;173(3):677-692
  • Marrone L, Japtok J, Reinhardt P, Janosch A, Andree A, Lee H, Moebius C, Reinhardt L,
    Hackmann K, Klink B, Alberti S, Bickle M, Hyman AA, Casci I, Pandey UB, Hermann A, and Sterneckert J. Phenotypic screening using iPSC reporter lines identifies brain-penetrant drugs stimulating autophagy as therapeutics for FUS-ALS. Stem Cell Reports 2018 Feb 13;10(2):375-389.
  • Kim SH, Stiles SG, Feichtmeier JM, Ramesh N, Zhan L, Scalf MA, Smith LM, Pandey
    UB, Tibbetts RS. Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS. Hum Mol Genet. 2018 Jan 15;27(2):322-337
  • Rudich P, Snoznik C, Watkins SC, Monaghan J, Pandey UB, Lamitina T. Nuclear localized C9orf72 associated arginine containing dipeptides exhibit age-dependent toxicity in C. elegans. Hum Mol Genet 2017 Dec 15;26(24):4916-492
  • Ramesh N, Pandey UB, Proteostasis dysfunction in ALS: Autophagy eating its way
    to prominence. Front Mol Neurosci (2017) Aug 22; 10:263
  • Daigle JG, Krishnamurthy K, Ramesh R, Casci I, Monaghan J, McAvoy K, Godfrey GW, Daniel D, Johnson E, Monahan Z, Shewmaker F, Pasinelli P, Pandey UB. Pur alpha ameliorates FUS toxicity and regulates cytoplasmic stress granule dynamics. Acta Neuropathologica 2016 Jan 4
  • Scaramuzzino C, Casci I, Parodi S, Lievens PMJ, Milioto C, Polanco MJ, Chivet M, Mishra A, Badders N, Aggarwal N, Grunseich C, Sambataro F, Basso M, Fackelmayer FO, Taylor JP, Pandey UB and Pennuto M. Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy. Neuron 2015 Jan 7; 84(7) 
  • Casci I and Pandey UB. A Fruitful Endeavor: Modeling ALS in the Fruit Fly. Brain Research 2015 May 14;1607:47-74
  • Wen X, Tan W, Westergard T, Krishnamurthy K,  Shamamandri Markandaiah S, Lin S, Ichida JK, Monaghan J, Pandey UB, Pasinelli P and Trotti D. Antisense Proline-Arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death, Neuron 2014 Dec 17;84(6)
  • Shahidullah M, Le Marchand SJ, Fei H, Zhang J, Pandey UB, Dalva MB, Pasinelli  P, Levitan IB. Defects in Synapse Structure and Function Precede Motor Neuron Degeneration in Drosophila Models of FUS-Related ALS. J Neurosci. 2013 Dec 11;33(50):19590-8
  • Daigle JG, Lanson NA, Smith RB, Casci I, Maltare A, Monaghan J, Nichols CD, Kryndushkin D, Shewmaker F, Pandey UB. RNA binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations. Human Molecular Genetics 2013 Mar 15;22(6):1193-205.
  • Lanson NA, Pandey UB. FUS-related Proteinpathies: Lessons from Animal Models. Brain Research 2012 Jun 26;1462:44-60.
  • Lanson NA, Maltare A, King H, Smith R, Kim JH, Taylor JP, Lloyd TE and Pandey UB. A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. Human Molecular Genetics 2011 Jul 1;20(13):2510-23. 
  • Batlevi Y, Simon C, Pandey UB, Powers C, Taylor JP, and Baehrecke EH. Dynein light chain 1 is required for autophagy, protein clearance and cell death in Drosophila, PNAS, 2010 107, 2
  • Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, Schwartz SL, DiProspero NA, Knight MA, Schuldiner O, Padmanabhan R, Hild M, Berry DL, Garza D, Hubbert CC, Yao TP, Baehrecke EH, Taylor JP. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature. 2007 Jun 14; 447(7146):860-4.
    *Previewed in Neuron and selected for ‘must read paper’ by faculty 1000 biology.
  • Pandey UB, Batlevi Y, Baehrecke EH, Taylor JP. HDAC6 at the Intersection of Autophagy, the Ubiquitin-proteasome System, and Neurodegeneration. Autophagy. 2007, 3 (6) 

View Dr. Pandey’s full list of publications from Pubmed 

Udai B Pandey