Ryan L. Minster, PhD, MSIS

Assistant Professor, Human Genetics


3118 Public Health
R-znvy: ezvafgre@cvgg.rqh
Primary Phone: 967-179-1473

Personal Statement

Dr Minster is a genetic epidemiologist who focuses on the genetics of complex traits such as body composition, obesity and healthy aging. He is particularly interested in pleiotropic relationships among complex phenotypes such as those between bone mineral density and geometry, lean muscle mass and fat mass. He is also interested in evidence of selection in population isolates and their impact on human disease.


1998 | University of Pittsburgh, Pittsburgh, PA | Bachelor of Science, Molecular Biology
2003 | University of Pittsburgh, Pittsburgh, PA | Master of Science in Information Science
2011 | University of Pittsburgh, Pittsburgh, PA | Doctor of Philosophy, Human Genetics



Genomic Data Processing & Structures | HUGEN 2071
Genomic Data Pipelines & Tools | HUGEN 2072
Genomic Data Visualization & Integration | HUGEN 2073
Genome Bioinformatics Capstone | HUGEN 2074


Bioinformatics Resources for Geneticists | HUGEN 2010
Bioinformatics for Human Genetics | HUGEN 2070
Statistical Genetics | HUGEN 2080

Selected Publications

J.C. Carlson, D.E. Weeks, N.L. Hawley, G. Sun, H. Chen, T. Naseri, M.S. Reupena, R. Deka, S.T. McGarvey & R.L. MinsterGenome-wide association studies in Samoans give insight into the genetic etiology of fasting serum lipid levelsbioRχiv.
DOI: 10.1101/411546


M. Krishnan, T.J. Major, R.K. Topless, O. Dewes, L. Yu, J.M.D. Thompson, L. McCowan, J. deZoysa, L.K. Stamp, N. Dalbeth, J. Harre ́ Hindmarsh, N. Rapana, R. Deka, W.W.H. Eng, D.E. Weeks, R.L. Minster, S.T. McGarvey, S. Viali, P. Wilcox, D. Grattan, P.R. Shepherd, A.N. Shelling, R. Murphy & T.R. Merriman. Discordant association of the crebrf rs373863828 minor allele with increased body mass index and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in New ZealandDiabetologia 61, 1603 (2018).
DOI: 10.1007/s00125-018-4623-1


A.T. Kraja, E.W. Daw, P. Lenzini, L. Wang, S.J. Lin, C.A. Williams, A.B. Wells, K.L. Lunetta, J.M. Murabito, P. Sebastiani, G. Tosto, S. Barral, R.L. Minster, A. Yashin, T. Perls & M.A. Province. A comparison of genetic imputation methods using Long Life Family Study genotypes and sequence data with the 1000 Genome reference panelInt. J. Bioinform. Res. Appl. in press.


M.M. Marron, J. Singh, R.M. Boudreau, K. Christensen, S. Cosentino, M.F. Feitosa, R.L. Minster, T. Perls, N. Schupf, P. Sebastiani, S. Ukraintseva, M.K. Wojczynski & A.B. Newman. A novel healthy blood pressure phenotype in the Long Life Family StudyJ. Hypertens. 36, 43 (2018).
DOI: 10.1097/hjh.0000000000001514


S.A. Sherman, R.J. Rogers, K.K. Davis, R.L. Minster, S.A. Creasy, N.C. Mullarkey, M. O’Dell, P. Donahue, J.M. Jakicic. Energy expenditure in vinyasa yoga versus walkingJ. Phys. Act. Health 19, 1–29 (2017).
DOI: 10.1123/jpah.2016-0548

J. Singh, R.L. Minster, N. Schupf, A. Kraja, Y. Liu, L. Christensen, A.B. Newman, C.M. Kammerer. Genomewide association scan of a mortality associated endophenotype for a long and healthy life in the Long Life Family StudyJ. Gerontol. A Biol. Sci. Med. Sci. in press.
DOI: 10.1093/gerona/glx011


R.L. Minster, N.L. Hawley, C.-T. Su, G. Sun, E.E. Kershaw, H. Cheng, O.D. Buhule, J. Lin, M.S. Reupena, S. Viali, J. Tuitele, T. Naseri, Z. Urban, R. Deka, D.E. Weeks, S.T. McGarvey. A thrifty variant in CREBRF strongly influences body mass index in SamoansNat. Genet. 48, 1049–54 (2016).
DOI: 10.1038/ng.3620


J.L. Sanders, J. Singh, R.L. Minster, J.D. Walston, A.M. Matteini, K. Christensen, R. Mayeux, I.B. Borecki, T. Perls, A.B. Newman. Association Between Mortality and Heritability of the Scale of Aging Vigor in EpidemiologyJ. Am. Geriatr. Soc. 64, 1679–83 (2016).
DOI: 10.1111/jgs.14190


R.L. Minster, J.L. Sanders, J. Singh, C.M. Kammerer, M.M. Barmada, A.M. Matteini, Q. Zhang, M.K. Wojczynski, E.W. Daw, J.A. Brody, A.M. Arnold, K.L. Lunetta, J.M. Murabito, K. Christensen, T.T. Perls, M.A. Province, & A.B. Newman. Genome-Wide Association Study and Linkage Analysis of the Healthy Aging IndexJ. Gerontol. A Biol. Sci. Med. Sci. 70, 1003–8 (2015).
DOI: 10.1093/gerona/glv006

B.A. Kozel, C.-T. Su, J.R. Danback, R.L. Minster, S. Madan-Khetarpal, J. McConnell, M.K. Mac Neal, K.L. Levine, R.C. Wilson, R.C. Sciurba & Z. Urban. Biomechanical properties of the skin in cutis laxa. J. Invest. Dermatol. 134, 2836–8 (2014).
DOI: 10.1038/jid.2014.224


O.D. Buhule, R.L. Minster, N.L. Hawley, M. Medvedovic, G. Sun, S. Viali, R. Deka, S.T. McGarvey, D.E. Weeks. Stratified randomization controls better for batch effects in 450K methylation analysis: a cautionary tale. Front. Genet. 5, 354 (2014).
DOI: 10.3389/fgene.2014.00354


N.L. Hawley, R.L. Minster, D.E. Weeks, S. Viali, M.S. Reupena, G. Sun, H. Cheng, R. Deka & S.T. McGarvey. Prevalence of adiposity and associated cardiometabolic risk factors in the Samoan Genome-Wide Association Study. Am. J. Hum. Biol. 26, 491–501 (2014).
DOI: 10.1002/ajhb.22553


Ryan L. Minster