Retention of 64Cu-FLFLF, a formyl peptide receptor 1-specific PET probe, correlates with macrophage and neutrophil abundance in lung granulomas from cynomolgus macaques. Mattila JT*, Beaino W, White AG, Nyiranshuti L, Maiello P, Tomko JA, Frye LJ, Fillmore D, Scanga CA, Lin PL, Flynn JL, Anderson CJ. In press: ACS Infectious Diseases. *co-corresponding author.
Zinc limitation triggers anticipatory adaptions in Mycobacterium tuberculosis. Dow A, Sule P, O'Donnell TJ, Burger A, Mattila JT, Antonio B, Vergara K, Marcantonio E, Adams LG, James N, Williams PG, Cirillo JD, Prisic S. PLoS Pathog. 2021 May 14;17(5)e:1009570. doi: 10.1371/journal.ppat.1009570. eCollection 2021 May.
Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Mycobacterium tuberculosis Granulomas. Millar JA, Butler JR, Evans S, Mattila JT, Linderman JJ, Flynn JL, Kirschner DE. Front Immunol. 2021 Jan 20;11:613638. doi: 10.3389/fimmu.2020.613638. eCollection 2020.PMID: 33552077.
Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation. Evans S, Butler JR, Mattila JT*, Kirschner DE. PLoS Comput Biol. 2020 Dec 28;16(12):e1008520. doi: 10.1371/journal.pcbi.1008520. eCollection 2020 Dec. *co-corresponding author
IL-10 Impairs Local Immune Response in Lung Granulomas and Lymph Nodes during Early Mycobacterium tuberculosis Infection. Wong EA, Evans S, Kraus CR, Engelman KD, Maiello P, Flores WJ, Cadena AM, Klein E, Thomas K, White AG, Causgrove C, Stein B, Tomko J, Mattila JT, Gideon H, Lin PL, Reimann KA, Kirschner DE, Flynn JL.J Immunol. 2020 Feb 1;204(3):644-659. doi: 10.4049/jimmunol.1901211. Epub 2019 Dec 20.
Neutrophils express pro- and anti-inflammatory cytokines in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques. Gideon HP, Phuah J, Junecko BA, Mattila JT. Mucosal Immunol. 2019 Nov;12(6):1370-1381. doi: 10.1038/s41385-019-0195-8. Epub 2019 Aug 21.
Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques. Ganchua SKC, Cadena AM, Maiello P, Gideon HP, Myers AJ, Junecko BF, Klein EC, Lin PL, Mattila JT, Flynn JL.PLoS Pathog. 2018 Nov 1;14(11):e1007337. doi: 10.1371/journal.ppat.1007337. eCollection 2018 Nov.
Monocyte and Alveolar Macrophage Skewing Is Associated with the Development of Pulmonary Arterial Hypertension in a Primate Model of HIV Infection. Schweitzer F, Tarantelli R, Rayens E, Kling HM, Mattila JT, Norris KA.AIDS Res Hum Retroviruses. 2019 Jan;35(1):63-74. doi: 10.1089/AID.2018.0132. Epub 2018 Oct 30.PMID: 30229666
Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology. Cicchese JM, Evans S, Hult C, Joslyn LR, Wessler T, Millar JA, Marino S, Cilfone NA, Mattila JT, Linderman JJ, Kirschner DE.Immunol Rev. 2018 Sep;285(1):147-167. doi: 10.1111/imr.12671.
Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model. Warsinske HC, Pienaar E, Linderman JJ, Mattila JT, Kirschner DE.Front Immunol. 2017 Dec 20;8:1843. doi: 10.3389/fimmu.2017.01843. eCollection 2017.
Mattila JT, Beaino W, Maiello P, Coleman MT, White AG, Scanga CA, Flynn JL, Anderson CJ. Positron Emission Tomography Imaging of Macaques with Tuberculosis Identifies Temporal Changes in Granuloma Glucose Metabolism and Integrin α4β1-Expressing Immune Cells. J Immunol. 2017 Jun 7. pii: ji1700231. doi: 10.4049/jimmunol.1700231.
Mattila JT, Maiello P, Sun T, Via LE, Flynn JL. Granzyme B-expressing neutrophils correlate with bacterial load in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques. Cell Microbiol. 2015 Aug;17(8):1085-97. doi: 10.1111/cmi.12428. Epub 2015 Mar 12.
Flynn JL, Gideon HP, Mattila JT, Lin PL. Immunology studies in non-human primate models of tuberculosis. Immunol Rev. 2015 Mar;264(1):60-73. doi:10.1111/imr.12258.
Pienaar E, Cilfone NA, Lin PL, Dartois V, Mattila JT, Butler JR, Flynn JL, Kirschner DE, Linderman JJ. A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment. J Theor Biol. 2015 Feb 21;367:166-79. doi: 10.1016/j.jtbi.2014.11.021. Epub 2014 Dec 9.
Cilfone NA, Ford CB, Marino S, Mattila JT, Gideon HP, Flynn JL, Kirschner DE, Linderman JJ. Computational modeling predicts IL-10 control of lesion sterilization by balancing early host immunity-mediated antimicrobial responses with caseation during mycobacterium tuberculosis infection. J Immunol. 2015 Jan 15;194(2):664-77. doi: 10.4049/jimmunol.1400734.
Marino S, Cilfone NA, Mattila JT, Linderman JJ, Flynn JL, Kirschner DE. Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection. Infect Immun. 2015 Jan;83(1):324-38. doi:10.1128/IAI.02494-14. Epub 2014 Nov 3.
Mattila JT, Fine MJ, Limper AH, Murray PR, Chen BB, Lin PL. Pneumonia. Treatment and diagnosis. Ann Am Thorac Soc. 2014 Aug;11 Suppl 4:S189-92. doi: 10.1513/AnnalsATS.201401-027PL. Review.
Mattila JT, Thomas AC. Nitric oxide synthase: non-canonical expression patterns. Front Immunol. 2014 Oct 9;5:478. doi: 10.3389/fimmu.2014.00478. eCollection 2014. Review.
Thomas AC, Mattila JT. "Of mice and men": arginine metabolism in macrophages. Front Immunol. 2014 Oct 7;5:479. doi: 10.3389/fimmu.2014.00479. eCollection 2014.Review.
Gong C, Mattila JT, Miller M, Flynn JL, Linderman JJ, Kirschner D. Predicting lymph node output efficiency using systems biology. J Theor Biol. 2013 Oct 21;335:169-84. doi:10.1016/j.jtbi.2013.06.016. Epub 2013 Jun 29.
Mattila JT, Ojo OO, Kepka-Lenhart D, Marino S, Kim JH, Eum SY, Via LE, Barry CE 3rd, Klein E, Kirschner DE, Morris SM Jr, Lin PL, Flynn JL. Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms. J Immunol. 2013 Jul 15;191(2):773-84. doi: 10.4049/jimmunol.1300113.
Diedrich CR, Mattila JT, Flynn JL. Monocyte-derived IL-5 reduces TNF production by Mycobacterium tuberculosis-specific CD4 T cells during SIV/M. tuberculosis coinfection. J Immunol. 2013 Jun 15;190(12):6320-8. doi: 10.4049/jimmunol.1202043. PMCID: PMC3677169.
Phuah JY, Mattila JT, Lin PL, Flynn JL. Activated B cells in the granulomas of nonhuman primates infected with Mycobacterium tuberculosis. Am J Pathol. 2012 Aug;181(2):508-14. doi: 10.1016/j.ajpath.2012.05.009. Epub 2012 Jun 19. Erratum in: Am J Pathol. 2012 Nov;181(5):1889.
Mattila JT, Diedrich CR, Lin PL, Phuah J, Flynn JL. Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation. J Immunol. 2011 Mar 15;186(6):3527-37. doi:10.4049/jimmunol.1003773. Epub 2011 Feb 11.
Green AM, Mattila JT, Bigbee CL, Bongers KS, Lin PL, Flynn JL. CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection. J Infect Dis. 2010 Aug 15;202(4):533-41. doi: 10.1086/654896.
Diedrich CR, Mattila JT, Klein E, Janssen C, Phuah J, Sturgeon TJ, Montelaro RC, Lin PL, Flynn JL. Reactivation of latent tuberculosis in cynomolgus macaques infected with SIV is associated with early peripheral T cell depletion and not virus load. PLoS One. 2010 Mar 10;5(3):e9611. doi: 10.1371/journal.pone.0009611.
Windish HP, Lin PL, Mattila JT, Green AM, Onuoha EO, Kane LP, Flynn JL. Aberrant TGF-beta signaling reduces T regulatory cells in ICAM-1-deficient mice, increasing the inflammatory response to Mycobacterium tuberculosis. J Leukoc Biol. 2009 Sep;86(3):713-25. doi:10.1189/jlb.1208740. Epub 2009 May 19. Erratum in: J Leukoc Biol. 2014 Sep;96(3):503-4.
Complete list of work available via NCBI My Bibliography: http://www.ncbi.nlm.nih.gov/sites/myncbi/1zcguUgIGy35Z/bibliography/47892992/public