Associate Professor, Environmental and Occupational Health
4116 Public Health, 130 De Soto Street, Pittsburgh, PA 15261
Primary Phone: 967-179-8027
Secondary Phone: 967-179-8997
Web site: http://www.pitt.edu/~jpp16/
The primary objective of the work in our laboratory is to elucidate the response of metalloproteins, especially hemoglobins and mitochondrial enzyme complexes, to environmental and occupational stressors/toxicants. We are also engaged in the search for chemical countermeasures to ameliorate the effects of the stressors/toxicants and the development of physical methods to study the sub-molecular, molecular and cellular mechanisms of intoxication and their antagonism by various antidotes.
1976 | University of Essex UK | BSc (Hon) Biological Chemistry
1981 | University of Essex UK | PhD Chemistry
Environmental Health Chemistry (EOH 2309)
Transport and Fate of Environmental Agents (EOH 2122)
Special Topics in Bio-inorganic Toxicology
J. Peterson*, L.L. Pearce and E.L. Bominaar: “Visible Region Magnetic Linear Dichroism Spectra of Ferrocytochrome c and Deoxymyoglobin: Demonstration of a New Tool for the Study of Metalloproteins”; J. Am. Chem. Soc, 121, 5972-5980 (1999).
A. J. Kannai*, L.L. Pearce, P.R. Clemens, L.A. Birder, M.M. VanBibber, S.-Y. Choi, W.C. deGroat, J. Peterson: “Identification of a Neuronal Nitric Oxide Synthase in Isolated Cardiac Mitochondria Using Electrochemical Detection”; Proc. Natl. Acad. Sci. USA, 98, 14126-14131 (2001).
Leah K. Cambal, Andrew C. Weitz, Hui-Hua Li, Yang Zhang, Xi Zheng, Linda L. Pearce, Jim
Peterson*: “Comparison of the relative propensities of isoamyl nitrite and sodium nitrite to ameliorate acute cyanide poisoning in mice and a novel antidotal effect arising from anesthetics”; Chem. Res. Toxicol. 26,
Oscar S. Benz, Quan Yuan, Andrew A. Amoscato, Linda L. Pearce, Jim Peterson “Co(III)TMPyP is an Antidote for Acute Cyanide Toxicity” Chemical Research in Toxicology. (2012)25, 2687–2703.
Sang-Min Lee, Joseph N. McLaughlin, Daniel R. Frederick, Lin Zhu, Karla Wasserloos, Iris Kaminski, Octavia Peck-Palmer ,Linda Pearce, Jim Peterson, CBI Person, Jin; Joseph D. Latoche, Tim D. Oury, Cheryl L. Fattman, Donna Beer-Stolz, John F. Alcorn, Derek C. Angus,
Bruce R. Pitt, A. Murat Kaynar “Metallothionien-induced zinc partitioning exacerbates hyperoxic induced lung injury”, Am J Physiol Lung Cell Mol Physiol March 1, (2013) 304:L350-L360
Leah K. Cambal Andrew C. Weitz, Hui-Hua Li, Xi Zheng, Linda L. Pearce and Jim Peterson “Alternative Nitrite Therapies for Acute Cyanide Poisoning in Mice: Complications Arising from Anesthetics” Chemical Research in Toxicology. (2013) May20;26(5):828-36. PMID:23536974.
Angela Fago, Alvin L. Crumbliss, Michael P. Hendrich, Linda L. Pearce, Jim Peterson, Robert Henkens, and Celia Bonaventura “Oxygen Binding to Partially Nitrosylated Hemoglobin” Biochimica Biophysica Acta - Proteins and Proteomics Biochimica et Biophysica Acta. (2013) April 25. PMID:23624264.
Andrea A. Cronican, Kristin L. Frawley, Humza Ahmed, Linda L. Pearce*and Jim Peterson* “Antagonism of Acute Sulfide Poisoning in Mice by Nitrite Anion without Methemoglobinemia” Chemical Research in Toxicology (2015)28(7) 1398-1408.
Oscar S. Benz, Quan Yuan, Andrea A. Cronican, Jim Peterson* and Linda L. Pearce* "Effect of Ascorbate on the Cyanide-Scavenging Capability of Cobalt(III) meso-Tetra(4-N-methylpyridyl)porphine Pentaiodide: Deactivation by Reduction?” Chemical Research in Toxicology (2016)29(3) 270-278.
Elisenda Lopez-Monzano, Andrea A. Cronican, Kristin L. Frawley, Jim Peterson* and Linda L. Pearce* “Cyanide Scavenging by a Cobalt Schiff-base Macrocycle: A Cost-effective Alternative to Corrinoids” Chemical Research in Toxicology (2016) April 22 DOI: 10.1021/acs.chemrestox.6b00070
Samantha L. Malone Rubright, Linda L. Pearce* and Jim Peterson** “Environmental Toxicology of Hydrogen Sulfide” (invited review) Nitric Oxide(2017) 71 (1) 1-13. DOI:10.1016/j.niox.2017.09.011
Quan Yuan, Linda L. Pearce,* and Jim Peterson* “Relative Propensities of Cytochrome c Oxidase and Cobalt Corrins for Reaction with Cyanide and Oxygen: Implications for Amelioration of Cyanide Toxicity” Chemical Research in Toxicology(2017) 30(12) 2197-2308. DOI:10.1021/acs.chemrestox.7b00275
Kristin L. Frawley, Andrea A. Cronican, Linda L. Pearce,* and Jim Peterson* “Sulfide Toxicity and Its Modulation by Nitric Oxide in Bovine Pulmonary Artery Endothelial Cells” Chemical Research in Toxicology(2017) 30(12) 2100-2009. DOI:10.1021/acs.chemrestox.7b00147
Andrea A. Cronican, Kristin L. Frawley, Erin P. Straw, Elisenda Lopez-Manzano, Hirunwut Praekunatham, Jim Peterson,* and Linda L. Pearce* “A Comparison of the Cyanide-Scavenging Capabilities of Some Cobalt-Containing Complexes in Mice” Chemical Research in Toxicology(2018) 31(4) 259-268. DOI:10.1021/acs.chemrestox.7b00314
Samantha L Malone, Linda L Pearce & Jim Peterson. Environmental Toxicology of Cyanide. Clinical and Experimental Toxicology of Cyanide. Chichester, UK: John Wiley & Sons. 2015.
Kristin L. Frawley, H. Praekunatham, Andrea A. Cronican, Jim Peterson and Linda L. Pearce “Assessing Modulators of Cytochrome c oxidase Activity in Galleria mellonella Larvae” Comp. Biochem. Physiol. C: Toxicol. & Pharm. (2019) 219, 77-86.
Kimberly K. Garrett, Kristin L. Frawley, Samantha Carpenter Totoni, Yookyung Bae, Jim Peterson* and Linda L. Pearce* “The Antidotal Action of Some Gold(I) Complexes Toward Phosphine Toxicity” Chemical Research in Toxicology (2019) May 16. doi: 10.1021/acs.chemrestox.9b00095. [Epub ahead of print]
Hirunwut Praekunatham, Linda L. Pearce* and Jim Peterson* “Reaction kinetics of cyanide binding to a cobalt Schiff-base macrocycle relevant to its mechanism of antidotal action” accepted, pending revision, by Chemical Research in Toxicology (2019).