Assistant Professor, Human Genetics
3122 Public Health Building, 130 DeSoTo street, Pittsburgh, PA 15216
Primary Phone: 967-838-5075
Web site: http://www.parklab.pitt.edu/
Dr. Park investigates large-scale behavior of molecular dynamics in human diseases using bioinformatics. Especially, he is identifying molecular mechanisms of human diseases across diverse types of genetic and epigenetic data through big data analysis and machine learning algorithms. In addition, he is interested in developing computational methods to predict treatment outcomes and elucidating translational implications of the predictions in collaborations.
2017 Postdoc Associate, Duncan Cancer Center (Wei Li, mentor), Baylor College of Medicine
2012 Ph.D., Computer Science (Luay Nakhleh, mentor), Rice University
2007 M.S., Computer Science (Tiffani Williams, mentor), Texas A&M University
2005 B.S., Computer Science, Yonsei University
H-J. Parkˆ, P. Jiˆ, S. Kim, Z. Xia, B. Rodriguez, C-P. Masamha, A-B, Shyu, J. Neilson, E.J. Wagner*, W. Li*, “3′ UTR shortening Down-regulates Tumor Suppressors in trans by Disrupting the CeRNA Crosstalk." Nature Genetics, 50, 783-789 (2018). DOI:10.1038
H. J. Park^*, S. Kim, W. Li*, “Model-based analysis of competing-endogenous pathways
(MACPath) in human cancers”, PLoS Computational Biology, 14(3): e1006074. DOI:10.1371.
M. Jeong^, H. J. Park^, H. Celik, E. L. Ostrander, J. M. Reyes, A. Guzman, B. Rodriguez, Y. Lee, L. Ding, O. A. Guryanova, W. Li, M. A. Goodell*, G. A. Challen*, “Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells in vivo”, Cell Reports, in press.
L. Minˆ, M. Jeongˆ, D. Sunˆ, H-J. Parkˆ, B. Rodriguezˆ, Z. Xia, L. Yang, X. Zhang, GJ. Darlington, W. Li* and M.A. Goodell*, “Long Non-coding RNAs Control Hematopoietic Stem Cell (HSC) Function." Cell Stem Cell, 16(4):426-38, 2015. DOI:10.1016/j.stem.2015.02.002
L. Wangˆ, H-J. Parkˆ, S. Wang, J-P Kocher, W. Li*, “CPAT: Coding-Potential Assessment Tool Using an Alignment-Free Logistic Regression Model." Nucleic Acid Research 41(6), 2013, DOI:10.1093/nar/gkt006
H-J. Parkˆ and L. Nakhleh*, “Inference of Reticulate Evolutionary Histories by Maximum Likelihood: The Performance of Information Criteria." BMC Bioinformatics, 13: S12, 2012. bmcbioinformatics.biomedcentral.com/articles