Haider H. Dar, PhD

Research Assistant Professor, Environmental and Occupational Health

Contact

Public Health Building, 130 De Soto Street, Pittsburgh, PA 15261
R-znvy: unq84@cvgg.rqh
Primary Phone: 967-838-5043
Web site:


Education

Undergraduate

2001 | Aligarh Muslim University, Aligarh, UP, India | Bachelor of Science | Chemistry

 

Graduate

2003 | School of Biotechnology, University of Jammu, Jammu, J&K, India | Master of Science | Biotechnology

2011 | Institute of Microbial Technology/Jawaharlal Nehru University, New Delhi, India | Ph. D | Biochemistry and Molecular Biology

 

Post-Graduate

2011-2014 | Research Center, Hospital Maisonneuve- Rosemont (HMR), University of Montreal, Quebec, Canada. | Postdoctoral Fellow | Biochemistry and Cell Biology.

2014-2014 | McMaster University, Hamilton, Onterio, Canada | Visiting Fellow | Microbiology


Teaching

2017-2020 | EOH 2310: Molecular Fundamentals


Selected Publications

H. H. Dar, T. S. Anthonymuthu, P. A. Ponomareva et al., (2021). A new thiol- independent mechanism of epithelial host defense against Pseudononas aeruginosa: iNOS/NO sabotage of theft-ferroptosis. (Accepted in Redox Biology,  Co-corresponding author).

 

A. M. Lamade, L. Wu, H. H. Dar, H. L. Mentrup, I. Shrivastava et al., (2021). Opposing roles of PEBP1 in regulated cell death: Curbing Necroptosis, Indorsing Ferroptosis. (Manuscript under revision in JCI).

 

W. Y. Sun, V. A. Tyurin, I. H. Shrivastava, B. Liu, Y. J. Zhai, S. Korolev, A. Y. Abramov, P. R. Angelova, O. Beharier,H. H. Dar, et al., (2021). Phospholipase iPLA 2 β averts fer- roptosis by eliminating a redox lipid death signal. Nature Chemical Biology. 17, 465-476.(PMID: 33542532).

 

T. S. Anthonymuthu, Y. Y. Tyurina, W. Y. Sun, K. Mikulska-Ruminska, I. H. Shrivastava, V. A. Tyurin, F. B. Cinemre, H. H. Dar et al., (2021) Resolving the paradox of ferroptotic cell death: ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of perox- idized ETE-PE, and protects against ferroptosis. Redox Biology. Jan;38:101744. (PMID: 33126055).

 

J. Zhao, H. H. Dar, Y. Deng, C. M. St Croix, Z. Li, Y. Minami et al., (2020). PEBP1 acts as a Rheostat between Pro-survival Autophagy and Ferroptotic Death in Asthmatic Epithelial Cells. Proc Natl Acad Sci U S A. 17(25):14376-14385. (PMID:32513718).

 

A. Kapralov*, Q. Yang*, H. H. Dar*, et al., (2020). Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nature Chemical Biology. 16:278-290. (PMID:32080625) (* Equal contribution).

 

T. Anthonymuthu, E. M. Kenny, I. Shrivastava, Y. Y. Tyurina, Z. E. Hier, H.C. Ting, H. H. Dar, et al., (2018). Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE. J. Am. Chem. Soc. 140 (51):17835-17839. (PMID:30525572).

 

H. H. Dar, Y. Y. Tyurina, K. Mikulska-Ruminska, I. Shrivastava, H.C. Ting, et al., (2018). Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium. Journal of Clinical Investigation. 128 (10):4639-4653. (PMID:30198910).

 

S. E. Wenzel, Y. Y. Tyurina, J. Zhao, C. M. St. Croix, H. H. Dar, et al., (2017). PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals Cell. 171(3):628-641. (PMID:29053969).

 

C. F. Chiu, H. H. Dar, A. A. Kapralov, R. A. S. Robinson, V. E. Kagan and A. Star (2017). Nano emitters and innate immunity: the role of surfactants in myeloperoxidase-catalyzed ox- idation of pristine single-walled carbon nanotubes. Nanoscale. 9 (18):5948-5956. (PMID:28440832).

 

V. E. Kagan, G. Mao, F. Qu, J. P. F. Angeli, S. Doll, C. St. Croix, H. H. Dar, et al., (2017). Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nature Chemical Biology. 13(1):81-90. (PMID:27842066).

 

V. E. Kagan, J. Jiang, Z. Huang, Y. Y. Tyurina, C. Desbourdes, C. Cottet-Rousselle, H. H. Dar, et al., (2016). NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy. Cell Death Differ. 23(7):1140-51. (PMID:26742431).

 

K. Balasubramanian, A. Maeda, J. S. Lee, D. Mohammadyani, H. H. Dar, et al (2015). Di- chotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phago- cytosis and attenuation of innate immunity. Science Signaling. Sep 22;8(395): ra95. (PMID:26396268).

 

N. Mashtalir, S. Daou, N. Sen, J. Gagnon, I. Hammon-Martel, H. H. Dar, M. Therrien and El B. Affar (2014). Autodeubiquitination protects the tumor suppressor BAP1 from cyto- plasmic sequestration mediated by atypical Ubiquitin ligase UBE2O. Mol Cell. May 8;54(3):392-406. (PMID:24703950).

 

H. H. Dar, D. Prasad, G. C. Varshney and P. K. Chakraborti (2011). Secretory Nucleoside diphosphate Kinase from both the Intra- and Extra- cellular Pathogenic Bacteria are function- ally indistinguishable. Microbioloby. 157, 3024-35. (PMID:21816881).

 

H. H. Dar and P. K. Chakraborti (2010). Intermolecular phosphotransfer is crucial for efficient catalytic activity of Nucleoside diphosphate kinase. Biochem J. 430, 539-549. (PMID:20575762).

 

R. Saxena, P. Kanudia, M. Datt, H. H. Dar, S. Karthikeyan, B. Singh and P. K. Chakraborti (2008). Three consecutive arginine’s are important for mycobacterial peptide deformylase enzyme activity. J. Biol. Chem. 283, 23754-23764. (PMID:18574247).

Haider H.  Dar