Allison L Kuipers, PhD

Dr. Kuipers' primary research is on the molecular determinants of cardiovascular and other age-related diseases. Her long-term interests stem from previous exposure to both laboratory and epidemiology research and include the development of translational approaches that move from “the bench to the population”. Dr. Kuipers’ current research is focused on identifying the role of the Wingless (Wnt) Pathway in human cardiovascular disease. She has an ancillary study of subclinical cardiovascular disease, including vascular calcification, carotid ultrasound, and pulse-wave velocity, in a population-based, longitudinal cohort study of African ancestry men on the Caribbean island of Tobago. Her aim is to use a variety of banked biospecimen samples in order to test the association of multiple molecular markers, such as genetic variation, gene expression, and protein concentration, with these subclinical measures in order to better understand the etiology and physiology of cardiovascular disease. She is also researching the role that aging plays in vascular health with both her own study and as a part of the Long Life Family Study, a family-based longitudinal cohort of exceptional longevity, for which a study site is located at the University of Pittsburgh. Her long term research goals are focused on using translational molecular techniques to study the interrelation and shared etiologies of an array of human chronic diseases, including cardiovascular disease, aging, hypertension, dyslipidemia, obesity, diabetes, kidney disease, and osteoporosis.

2014 | University of Pittsburgh, Pittsburgh, PA | NHLBI T32 Post-doctoral Fellowship
2011 | University of Pittsburgh, Pittsburgh, PA | PhD in Epidemiology
2011 | University of Pittsburgh, Pittsburgh, PA | Certificate in Public Health Genetics
2011 | University of Pittsburgh, Pittsburgh, PA | NHLBI T32 Pre-doctoral Fellowship
2007 | University of Pittsburgh, Pittsburgh, PA | BS in Biological Sciences

EPIDEM 2600: Molecular Epidemiology (Spring Semester)

An updated, complete list of publications can be found at: https://www.ncbi.nlm.nih.gov/myncbi/allison.kuipers.1/bibliography/public/

A selection of recent and influential works include: 

1.     Kuipers AL, Miljkovic I, Kammerer CM, Evans RW, Bunker CH, Patrick AL, Wheeler VW, Sutton-Tyrrell K, Zmuda JM. Evidence for a genetic link between bone and vascular measures in African ancestry families. J Bone Miner Res. Aug 2013. 28(8):1804-10.

2.     Kuipers AL, Kammerer CM, Miljkovic I, Woodard G, Miljkovic I, Bunker CH, Patrick AL, Wheeler VW, Newman AB, Zmuda JM. Genetic epidemiology and genome-wide linkage analysis of carotid artery ultrasound traits in multigenerational African ancestry families. Atherosclerosis. Nov 2013. 231(1):120-3.

3.     Kuipers AL, Zmuda JM, Carr JJ, Terry JG, Bunker CH, Patrick AL, Wheeler VW, Miljkovic I. Association of Volumetric Bone Mineral Density with Aortic Calcification in African Ancestry Men. Osteoporosis Int. Mar 2014. 25(3):1063-9.

4.     Kuipers AL, Miljkovic I, Carr JJ, Terry JG, Nestlerode CS, Ge Y, Bunker CH, Patrick AL, Zmuda J. Association of Circulating Sclerostin with Vascular Calcification in Afro-Caribbean Men. Atherosclerosis. Jan 2015. 17(239):218-23.

5.  Kuipers AL, Egwuogu H, Evans RW, Patrick AL, Youk AY, Bunker CH, Zmuda JM. Renal function and bone loss in a cohort of Afro-Caribbean men. J Bone Miner Res. Dec 2015. 30(12):2215-20.

6.  Kuipers AL, Miljkovic I, Evans R, Bunker CH, Patrick AL, Zmuda JM. Optimal serum cholesterol concentrations are associated with accelerated bone loss in African ancestry men. Osteoporos Int. Apr 2016. 27(4):1577-84.

7.  Kuipers AL, Kammerer CM, Pratt JH, Gundberg C, Bunker CH, Wheeler VW, Patrick AL, Zmuda JM. Association of plasma renin activity with osteocalcin and bone mineral density in African ancestry families. Hypertension. May 2016. 67(5):977-82.

8. Kuipers AL, Zmuda JM, Carr JJ, Terry JG, Nair S, Cvejkus R, Bunker CH, Patrick AL, Wassel CL, Miljkovic I. Association of Ectopic Fat with Abdominal Aorto-Illiac and Coronary Artery Calcification in African Ancestry Men. Atherosclerosis. June 2017. 263:198-204.

9. Kuipers AL, Miljkovic I, Barinas-Mitchell E, Cvejkus R, Bunker CH, Wheeler VW, Zmuda JM. Arterial stiffness and hypertension status in Afro-Caribbean men.  J Hypertens. 2019. 37(3):546-54.

10. Kuipers AL, Wojczynski MK, Barinas-Mitchell E, Minster RL, Wang L, Feitosa MF, Kulminski A, Thyagarajan B, Lee JH, Province MA, Newman AB, Zmuda JM. Genome-wide linkage analysis of carotid artery traits in exceptionally long-lived families. Athersclerosis. 2019. Oct 10(291):19-26.

11. Kuipers AL, Miljkovic I, Barinas-Mitchell E, Nestlerode CS, Cvejkus RK, Wheeler VW, Zhang Y, Zmuda JM. Wnt pathway gene expression is associated with arterial stiffness. J Am Heart Assoc. 2020. 9(3):e014170.