Epidemiology Department Events

Epidemiology Dissertation Defense

Mary Winger - Asso. betwn. Muscle Function, Physical Performance, and Falls in Older Adults ONLINE

Friday 4/10 2:00PM - 4:00PM

Epidemiology doctoral candidate Mary Winger defends her dissertation "The Association Between Muscle Function, Physical Performance, and Falls and Fall Injuries in Older Adults." This defense will take place virtually using Zoom.

COMMITTEE:
Elsa S. Strotmeyer (Advisor/Committee Chair) - Dept. of Epidemiology
Jane A. Cauley - Dept. of Epidemiology
Robert M. Boudreau - Dept. of Epidemiology
Sara R. Piva - Dept. of Physical Therapy

PARTICIPATE VIA ZOOM VIDEO CONFERENCE
https://pitt.zoom.us/j/350349915

Abstract
Background: Weight-bearing measures of lower-extremity muscle mechanical function may be more strongly related to physical performance and fall injury than non-weight-bearing measures in older adults. However, these relationships are not well-described since past studies have typically not included multiple muscle function and physical performance measures, or non-fracture fall injuries.

Objectives: This dissertation examined associations of (1) multiple muscle function measures (lower-extremity muscle power and strength, and grip strength) with physical performance, (2) novel jump test measures (jump power, velocity and force) and grip strength with physical performance, and (3) baseline leg power and grip strength with incident fall injuries (non-fracture and fractures).

Methods: Study populations included community-dwelling older adults from the (1) Developmental Epidemiologic Cohort Study (N=68; age=78.5±5.5 years; 57% women), (2) Osteoporotic Fractures in Men (MrOS) Study clinic visit 4 (N=1,242 age=84±4 years), and (3) MrOS baseline clinic visit with fall injury follow-up data (N=5,994; age 73.7±5.9 years). Multiple regression analyses with standardized βs were applied to objectives 1 and 2, and generalized estimating equations with unstructured correlation were applied to objective 3.

Results: First, jump power had a higher magnitude of association with faster gait speed than any other power or strength measures, a magnitude of association with faster 400m walk time that was similar to Keiser power and higher than other power and strength measures, and a lower magnitude of association with chair stands speed than any other power or strength measures. Secondly, power and velocity were associated with worse gait speed, 400m walk time and chair stands speed, whereas force and grip strength were more weakly associated with physical performance. Finally, both lower leg power and grip strength were associated with increased fall injury risk.

Conclusion: These findings suggest that muscle function impairments are related to physical performance, including mobility, and fall injuries in older adults. Future studies should examine longitudinal associations of muscle function changes with changes in geriatric outcomes related to physical performance, mobility and falls. The public health relevance of current findings is that identifying potential earlier muscle function predictors of disability may inform prevention efforts that would ultimately reduce disability incidence.  

Last Updated On Wednesday, April 8, 2020 by Smith, Lori Sarracino
Created On Friday, March 27, 2020