Presenter: Brandy Hill
Paper: Ambient black carbon particles reach the fetal side of human placenta
Authors: Hannelore Bové, Eva Bongaerts, Eli Slenders, Esmée M. Bijnens, Nelly D. Saenen, Wilfried Gyselaers, Peter Van Eyken, Michelle Plusquin, Maarten B.J. Roeffaers, Marcel Ameloot & Tim S. Nawrot
Particle transfer across the placenta has been suggested but to date, no direct evidence in real-life, human context exists. Here we report the presence of black carbon (BC) particles as part of combustion-derived particulate matter in human placentae using white-light generation under femtosecond pulsed illumination. BC is identified in all screened placentae, with an average (SD) particle count of 0.95 × 104 (0.66 × 104) and 2.09 × 104 (0.9 × 104) particles per mm3 for low and high exposed mothers, respectively. Furthermore, the placental BC load is positively associated with mothers’ residential BC exposure during pregnancy (0.63 2.42 μg per m3). Our finding that BC particles accumulate on the fetal side of the placenta suggests that ambient particulates could be transported towards the fetus and represents a potential mechanism explaining the detrimental health effects of pollution from early life
Presented by Beth L. Roman, associate professor of human genetics, member of the Heart, Lung, and Blood Vascular Medicine Institute, and basic research director, HHT Center.
Chair - International Clinical Research Centre
Principle Investigator - Translational Ageing and Neuroscience Program,
Centre for Translational Medicine
International Clinical Research Centre, St. Anne's University Hospital
Brno, Czech Republic
Last Updated On Thursday, July 19, 2018 by McCullough, Caitlin Emily
Created On Monday, July 16, 2018
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