EOH Journal Club

EOH Journal Club - Fall 2017 - Brandy Hill

Thursday 11/16 11:00AM - 12:00PM
EOH Journal Club Seminar - Fall 2017

Date: Thursday November 16, 2017

Time: 11am - 12pm

Presenter: Brandy Hill

Paper:  Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study

Authors: Eunice Y. Lee, MS, Jue Lin, PhD, Elizabeth M. Noth, PhD, S. Katharine Hammond, PhD, Kari C. Nadeau, MD, PhD, Ellen A. Eisen, ScD, and John R. Balmes, MD

Objective: The main objective of this pilot study was to gather preliminary information about how telomere length (TL) varies in relation to exposure to polycyclic aromatic hydrocarbons (PAHs) in children living in a highly
polluted city.

Methods: We conducted a cross-sectional study of children living in Fresno, California (n¼14). Subjects with and without asthma were selected based on their annual average PAH level in the 12-months prior to their blood draw. We measured relative telomere length from peripheral blood mononuclear cells (PBMC).

Results: We found an inverse linear relationship between average PAH level and TL (R2¼0.69), as well as between age and TL (R2¼0.21). Asthmatics had shorter mean telomere length than non-asthmatics (TLasthmatic¼1.13, TLnon-asthmatic¼1.29).

Conclusions: These preliminary findings suggest that exposure to ambient PAH may play a role in telomere shortening.

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Last Updated On Friday, October 27, 2017 by Orbell, Adam W
Created On Monday, October 2, 2017