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EOH Journal Club

Ambient black carbon particles reach the fetal side of human placenta

Thursday 1/23 11:00AM - 12:00PM
4140 Public Health, Young Seminar Room

Presenter: Brandy Hill

Paper: Ambient black carbon particles reach the fetal side of human placenta

Authors: Hannelore Bové, Eva Bongaerts, Eli Slenders, Esmée M. Bijnens, Nelly D. Saenen, Wilfried Gyselaers, Peter Van Eyken, Michelle Plusquin, Maarten B.J. Roeffaers, Marcel Ameloot & Tim S. Nawrot

Particle transfer across the placenta has been suggested but to date, no direct evidence in real-life, human context exists. Here we report the presence of black carbon (BC) particles as part of combustion-derived particulate matter in human placentae using white-light generation under femtosecond pulsed illumination. BC is identified in all screened placentae, with an average (SD) particle count of 0.95 × 104 (0.66 × 104) and 2.09 × 104 (0.9 × 104) particles per mm3 for low and high exposed mothers, respectively. Furthermore, the placental BC load is positively associated with mothers’ residential BC exposure during pregnancy (0.63 2.42 μg per m3). Our finding that BC particles accumulate on the fetal side of the placenta suggests that ambient particulates could be transported towards the fetus and represents a potential mechanism explaining the detrimental health effects of pollution from early life

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Last Updated On Wednesday, January 15, 2020 by Orbell, Adam W
Created On Wednesday, January 15, 2020