SPECIALTY PHARMACY TIMES - A new studying has found a correlation between children born to pre-pregnancy body-mass index (BMI) and the likelihood of developing childhood cancer, even after correcting for known risk factors, such as newborn size and maternal age. "My hope is that this study can be, in a way, empowering and also motivating for weight loss," said lead author Shaina Stacy (EOH '15 '12).
KDKA RADIO – The Clairton Coke Works is one of the biggest emitters of air pollutants in the area and there is a lot of anecdotal evidence about poor health in that area. EOH’s Jim Fabisiak and Brandy Hill (EOH ‘21) talk about their work and the importance of scientific investigation learning about asthma patients in the county, following hot spots of asthma, and preliminarily finding about the Mon Valley’s lung health.
PITTSBURGH TRIBUNE REVIEW - A fire at the U.S. Steel Clairton Plant knocked pollution controls offline and heightened concerns about pollution. Allegheny County ranks in the top 2% for cancer risk from about 200 potentially cancer-causing pollutants identified by the EPA, according to a 2013 Pitt Public Health report. "That risk is going to be much more elevated the closer you are to those point sources," said EOH's Jim Fabisiak.
SCIENCE - The EPA plans to quickly revap its guidelines for evaluating whether environmental contaminants can cause cancer or other ailments, a move Trump administration critics fear is part of a broader effort to weaken the basis for regulating a wide range of pollutants. "The problem is, there's no way it can be done in any serious way," said EOH's Bernard Goldstein, dean emeritus. "The danger is you'll just get it wrong and for 15 years, you'...
NEXT PITTSBURGH - While U.S. Steel has recently completed repairs and pledged to spend $1 billion to upgrade facilities, public outrage over violations hasn't been quieted. "I think the economic factors have outweighed the health factors," says EOH's Sally Wenzel. "I think that has been an issue with the Pittsburgh area for a while."
PITTSBURGH POST-GAZETTE - EOH Chair Sally Wenzel was an investigator in the clinical trial for the new biologic drug dupilumab, marketed as Dupixent and approved by the federal Food and Drug Administration last fall. The drug is part of the effort to help patients with severe asthma who don’t get control by using their regular long-term control medications, such as inhaled corticosteriods and bronchodilator medication, to open up and reduce swel...
THE WASHINGTON POST - A powerful op-ed from Bernard Goldstein, dean emeritus and former head of the EPA's Office of Research and Development under Ronald Reagan. "I would have resigned either position had the agency’s overall advisory processes been subject to its current destructive alterations."
WESA FM - It’s been more than three months since a fire at U.S. Steel’s Clairton Coke Works significantly increased emissions of sulfur dioxide, and Mon Valley residents say it's still affecting their quality of life. On the debut of a new occasional series, "Moment of Science," 90.5 WESA’s Liz Reid talked with EOH's Jim Fabisiak about how sulfur dioxide affects the human body.
MEDPAGE TODAY - With the aid of a computational tool, Wenzel says they have identified key phenotypes among patients with severe asthma that can help predict who may benefit and not benefit from treatment with systemic corticosteroids (CS). Aware of the possible side effects, EOH's Sally Wenzel said, “physicians would like to prescribe them only to patients they know will benefit from them.”
While important in the treatment of the common and often life-long respiratory disease, corticosteroids aren't without side effects and for some patients, the treatment just isn't as effective. EOH Chair Sally Wenzel and colleagues used a machine learning algorithm and identified variables that allowed them to cluster patients based on response.
EARTH.COM NEWS - EOH's Bernard Goldstein told the Wall Street Journal that the report shows that the Trump administration is challenging the EPA's long-held standard approaches to science.
ENVIRONMENTAL HEALTH NEWS - Around one in three Americans gets a cancer diagnosis during their lifetime. "If someone chooses to smoke, most of the risk will only impact them," said James Fabisiak. "When we think about air pollution, on the other hand, the risk is smaller than smoking but that risk is now distributed over a much wider segment of the population."
UPMC - New research, developed largely from Amrita Sahu's (EOH) thesis work, implicates the so-called “longevity protein” Klotho, both as culprit and therapeutic target to the inability for skeletal muscle to hear after injury as we get older. “We found that we were able to rescue, at least in part, the regenerative defect of aged skeletal muscle,” said lead author, EOH's Fabrisia Ambrosio.
PITT MED - Cells die—that’s just part of life. But there’s always a reason. Pitt scientists are figuring out how to keep programmed cell death in check. EOH's VALERIAN KAGAN and SALLY WENZEL and other colleagues including EOH's HULYA BAYIR, are partnering to better understand “the reason” for ferroptosis—exactly what biomolecular line is crossed, how that signal is communicated within and between cells, which molecules pull the trigger, and how....