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The University's Guidance on Events and Gatherings directs that "In order to promote social distancing, any nonessential gathering or event with more than 25 participants scheduled through April 17, 2020, should be canceled, postponed or moved to a virtual event. No new events should be scheduled at this time. Additionally, nonessential meetings or events of any size should be reconsidered."

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EOH Journal Club

M2 polarization of macrophages facilitates arsenic-induced cell transformation of lung - ONLINE

Thursday 4/16 11:00AM - 12:00PM

Join Zoom Meeting Meeting ID: 848 181 150

Presenter: Grace Ge

Paper: M2 polarization of macrophages facilitates arsenic-induced cell transformation of lung epithelial cells

Authors:  Jiajun Cui, Wenhua Xu, Jian Chen, Hui Li, Lu Dai, Jacqueline A. Frank,Shaojun Peng, Siying Wang, Gang Chen

Abstract: The alterations in microenvironment upon chronic arsenic exposure may
contribute to arsenic-induced lung carcinogenesis. Immune cells, such as
macrophages, play an important role in mediating the microenvironment in the lungs.
Macrophages carry out their functions after activation. There are two activation status
for macrophages: classical (M1) or alternative (M2); the latter is associated with
tumorigenesis. Our previous work showed that long-term arsenic exposure induces
transformation of lung epithelial cells. However, the crosstalk between epithelial cells
and macrophages upon arsenic exposure has not been investigated. In this study,
using a co-culture system in which human lung epithelial cells are cultured with
macrophages, we determined that long-term arsenic exposure polarizes macrophages
towards M2 status through ROS generation. Co-culture with epithelial cells further
enhanced the polarization of macrophages as well as transformation of epithelial cells,
while blocking macrophage M2 polarization decreased the transformation. In addition,
macrophage M2 polarization decreased autophagy activity, which may account for
increased cell transformation of epithelial cells with co-culture of macrophages.

Click Here For Article

Last Updated On Wednesday, March 25, 2020 by Tatone, Kelly Lee
Created On Wednesday, February 5, 2020