Events Calendar

Event changes/cancellations due to COVID-19

The University's Guidance on Events and Gatherings directs that "In order to promote social distancing, any nonessential gathering or event with more than 25 participants scheduled through April 17, 2020, should be canceled, postponed or moved to a virtual event. No new events should be scheduled at this time. Additionally, nonessential meetings or events of any size should be reconsidered."

As many events and gatherings will be impacted over the coming weeks, before attendingplease confirm whether an event has been canceled or moved online. Check  publichealth.pitt.edu/calendar for the latest updates and cancellations. 

EOH Journal Club

Human & mouse single-nucleus transcriptomics reveal TREM2-dependent & TREM2-independent - ONLINE

Thursday 4/2 11:00AM - 12:00PM

Join Zoom Meeting - https://pitt.zoom.us/j/356770679 Meeting ID: 356 770 679

Presenter: Yi Lu

Paper: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

Authors: Yingyue Zhou, Wilbur M. Song, Prabhakar S. Andhey, et Al.

Abstract:
Glia have been implicated in Alzheimer’s disease (AD) pathogenesis. Variants of the microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD risk, and activation of disease-associated microglia (DAM) is dependent on TREM2 in mouse models of AD. We surveyed gene-expression changes associated with AD pathology and TREM2 in 5XFAD mice and in human AD by single-nucleus RNA sequencing. We confirmed the presence of Trem2-dependent DAM and identified a previously undiscovered Serpina3n+C4b+ reactive oligodendrocyte population in mice. Interestingly, remarkably differential phenotypes were evident in human AD. Microglia signature was reminiscent of IRF8-driven reactive microglia in peripheral- nerve injury. Oligodendrocyte signatures suggested impaired axonal myelination and metabolic adaptation to neuronal degeneration. Astrocyte profiles indicated weakened metabolic coordination with neurons. Notably, the reactive phenotype of microglia was less evident in TREM2-R47H and TREM2-R62H carriers than in non-carriers,

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Last Updated On Wednesday, March 25, 2020 by Tatone, Kelly Lee
Created On Wednesday, January 29, 2020