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Event changes/cancellations due to COVID-19

The University's Guidance on Events and Gatherings directs that "In order to promote social distancing, any nonessential gathering or event with more than 25 participants scheduled through April 17, 2020, should be canceled, postponed or moved to a virtual event. No new events should be scheduled at this time. Additionally, nonessential meetings or events of any size should be reconsidered."

As many events and gatherings will be impacted over the coming weeks, before attendingplease confirm whether an event has been canceled or moved online. Check  publichealth.pitt.edu/calendar for the latest updates and cancellations. 

EOH Journal Club

Organophosphorus pesticide chlorpyrifos intake promotes obesity and insulin resistance - ONLINE

Thursday 4/9 11:00AM - 12:00PM

Join Zoom Meeting https://pitt.zoom.us/j/152532472  Meeting ID: 152 532 472

Presenter: Jenna Kuhn

Paper: Organophosphorus pesticide chlorpyrifos intake promotes obesity and insulin resistance through impacting gut and gut microbiota

Authors: Yiran Liang, Jing Zhan, Donghui Liu, Mai Luo, Jiajun Han, Xueke Liu, Chang Liu, Zheng Cheng, Zhiqiang Zhou, and Peng Wang

Abstract:
Background
Disruption of the gut microbiota homeostasis may induce low-grade inflammation leading to obesity-associated diseases. A major protective mechanism is to use the multi-layered mucus structures to keep a safe distance between gut epithelial cells and microbiota. To investigate whether pesticides would induce insulin resistance/obesity through interfering with mucus-bacterial interactions, we conducted a study to determine how long-term exposure to chlorpyrifos affected C57Bl/6 and CD-1 (ICR) mice fed high- or normal-fat diets. To further investigate the effects of chlorpyrifos-altered microbiota, antibiotic treatment and microbiota transplantation experiments were conducted.

Results
The results showed that chlorpyrifos caused broken integrity of the gut barrier, leading to increased lipopolysaccharide entry into the body and finally low-grade inflammation, while genetic background and diet pattern have limited influence on the chlorpyrifos-induced results. Moreover, the mice given chlorpyrifos-altered microbiota had gained more fat and lower insulin sensitivity.

Conclusions
Our results suggest that widespread use of pesticides may contribute to the worldwide epidemic of inflammation-related diseases.

Click Here For Article

Last Updated On Wednesday, March 25, 2020 by Tatone, Kelly Lee
Created On Tuesday, January 21, 2020