Biostatistics Seminar Series

Biostatistics Seminar: Russell Shinohara, University of Pennsylvania

Thursday 2/25 3:30PM - 4:30PM

A115 Crabtree Hall

Visit publichealth.pitt.edu/calendar or
publichealth.pitt.edu/biostatistics-seminars  for details.


Biostatistics 2016 Spring Seminar Speaker Series presents

2/25/2016
RUSSELL (TAKI)  SHINOHARA, PHD
Assistant Professor of Biostatistics in Department of Biostatistics and Epidemiology 
University of Pennsylvania, Perelman School of Medicine

"DEVELOPING TISSUE DAMAGE AND REPAIR BIOMARKERS FROM CONVENTIONAL MAGNETIC RESONANCE NEUROIMAGING"

While conventional magnetic resonance imaging (MRI) is measured in arbitrary intensity units, much work has centered on the development of normalization procedures. In this talk, we propose a simple, fast, and robust statistical normalization method which does not require prior segmentation of a reference tissue. This technique allows us to measure changes across the brain using conventional MRI in interpretable statistical units, providing a promising new tool for large multi-center studies and clinical practice in which conventional MRI are used routinely. We then propose methods for the identification of multiple sclerosis (MS) white matter lesions both cross-sectionally and longitudinally at the population level using these statistically normalized images which are now quantitative. Finally, we examine the prospect of quantifying disease activity and tissue damage using our statistical quantitative MRI, derived solely from widely available conventional MRI, compared to contrast-enhanced and advanced quantitative MRI modalities. Our preliminary results indicate that statistical quantitative MRI is significantly less costly, less invasive, and yet may provide more precise and sensitive biomarkers for disease-related changes in MS on MRI. 

DocumentSeminar Flyer - Taki Shinohara.pdf


Thursdays  |  3:30 pm  |   A115 Crabtree Hall 

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Created On Monday, March 21, 2016