Biostatistics Seminar Series

## Jingyi (Jessica) Li, University of California, Los Angeles

Thursday 11/1 3:30PM - 4:30PM

Public Health Auditorium (G23)

Public Health Auditorium (G23)

In many binary classification application in biomedical sciences, such as disease diagnosis, practitioners commonly face the need to control type I error (i.e., the conditional probability of misclassifying a class 0 observation as class1) so that it remains below a desired threshold. To address this need, the Neyman-Pearson (NP) classification paradigm is a natural choice; it minimizes type II error (i.e., the conditional probability of misclassifying a class 1 observation as class 0) while enforcing an upper bound, alpha, on the type I error. Although the NP paradigm has a century-long history in hypothesis testing, it has not been well recognized and implemented in classification schemes. Common practices that directly control the empirical type I error to no more than alpha do not satisfy the type I error control objective because the resulting classifiers are still likely to have type I errors much larger than alpha. As a result, the NP paradigm has not been properly implemented for many classification scenarios in practice. In this work, we develop the first umbrella algorithm that implements the NP paradigm for all scoring-type classification methods, such as logistic regression, support vector machines and random forests. Powered by this umbrella algorithm, we propose a novel graphical tool for NP classification methods: NP receiver operating characteristic (NP-ROC) bands, motivated by the popular receiver operating characteristic (ROC) curves. NP-ROC bands will help choose alpha in a data adaptive way and compare different NP classifiers. We demonstrate the use and properties of the NP umbrella algorithm and NP-ROC bands, available in the R package nproc, through simulation and real data case studies.

Last Updated On Friday, October 19, 2018 by Tang, Lu

Created On Friday, August 24, 2018