IDM Events

IDM Departmental Calendar

Event
Mon 10/21/2019 1:00PM - 2:00PM
IDM Seminar Series
Presentation by: Subramanian Thothathri & Jason Yeung IDM Seminar Series
Presentation by: Subramanian Thothathri & Jason Yeung
Mon 10/21/2019 1:00PM - 2:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
Tue 10/22/2019 5:00PM - 8:30PM
MidAtlantic AIDS Education and Training Center Conference
Erie HIV Update: Reducing Stigma and Improving Sexual Health MidAtlantic AIDS Education and Training Center Conference
Erie HIV Update: Reducing Stigma and Improving Sexual Health
Tue 10/22/2019 5:00PM - 8:30PM
Outside Conference and Meeting Spaces

This evening dinner update, in collaboration with the Erie Department of Health and Erie HIV Task Force, will be held at the Bayfront Convention Center.  The presenters will discuss Sexual Health History Taking and Sexual Health and Stigma, followed by a panel of local providers.


Outside Conference and Meeting Spaces
Wed 10/23/2019 12:00PM - 1:00PM
IDM PhD & MS Journal Club
Article - TBA IDM PhD & MS Journal Club
Article - TBA
Wed 10/23/2019 12:00PM - 1:00PM
A719 Public Health


A719 Public Health
Wed 10/23/2019 12:00PM - 1:00PM
IDM MPH Journal Club
Practicum Panel: 1st & 2nd Years IDM MPH Journal Club
Practicum Panel: 1st & 2nd Years
Wed 10/23/2019 12:00PM - 1:00PM
A216 Public Health


A216 Public Health
Mon 10/28/2019 12:00PM - 1:00PM
IDM Seminar Series
Presentations by: Byron Chuan & Zachary Koenig IDM Seminar Series
Presentations by: Byron Chuan & Zachary Koenig
Mon 10/28/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
Wed 10/30/2019 12:00PM - 1:00PM
IDM PhD & MS Journal Club
Article - TBA IDM PhD & MS Journal Club
Article - TBA
Wed 10/30/2019 12:00PM - 1:00PM
A719 Public Health


A719 Public Health
Wed 10/30/2019 12:00PM - 1:00PM
IDM MPH Journal Club
Article - Metagenomic analysis of viruses in toilet waste from long distance flights --.... IDM MPH Journal Club
Article - Metagenomic analysis of viruses in toilet waste from long distance flights --....
Wed 10/30/2019 12:00PM - 1:00PM
A425 Public Health


A425 Public Health
Mon 11/4/2019 12:00PM - 1:00PM
IDM Seminar Series
Presentation by Mari Webel, PhD IDM Seminar Series
Presentation by Mari Webel, PhD
Mon 11/4/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
Wed 11/6/2019 12:00PM - 1:00PM
IDM PhD & MS Journal Club
Article - TBA IDM PhD & MS Journal Club
Article - TBA
Wed 11/6/2019 12:00PM - 1:00PM
A719 Public Health


A719 Public Health
Wed 11/6/2019 12:00PM - 1:00PM
IDM MPH Journal Club
Article - Effect of Microglial Inflammation in Prion Disease IDM MPH Journal Club
Article - Effect of Microglial Inflammation in Prion Disease
Wed 11/6/2019 12:00PM - 1:00PM
A425 Public Health


A425 Public Health
Mon 11/11/2019 12:00PM - 1:00PM
IDM Seminar Series
Presentations by: Emily Olsen & Karsen Shoger IDM Seminar Series
Presentations by: Emily Olsen & Karsen Shoger
Mon 11/11/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
Wed 11/13/2019 12:00PM - 1:00PM
IDM PhD & MS Journal Club
Article - TBA IDM PhD & MS Journal Club
Article - TBA
Wed 11/13/2019 12:00PM - 1:00PM
A719 Public Health


A719 Public Health
Mon 11/18/2019 12:00PM - 1:00PM
IDM Seminar Series
Presentations by: Victoria Gould & Katrina Stephenson IDM Seminar Series
Presentations by: Victoria Gould & Katrina Stephenson
Mon 11/18/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
Wed 11/20/2019 12:00PM - 1:00PM
IDM PhD & MS Journal Club
Article - TBA IDM PhD & MS Journal Club
Article - TBA
Wed 11/20/2019 12:00PM - 1:00PM
A719 Public Health


A719 Public Health
Wed 11/20/2019 12:00PM - 1:00PM
IDM MPH Journal Club
Article - Pulmonary involvement during the Ebola Virus Disease IDM MPH Journal Club
Article - Pulmonary involvement during the Ebola Virus Disease
Wed 11/20/2019 12:00PM - 1:00PM
A425 Public Health


A425 Public Health
Wed 11/20/2019 12:00PM - 1:00PM
IDM MPH Journal Club
Article - TBA IDM MPH Journal Club
Article - TBA
Wed 11/20/2019 12:00PM - 1:00PM
A425 Public Health


A425 Public Health
Mon 12/2/2019 12:00PM - 1:00PM
IDM Seminar Series
Presentation by: Gwen Kettenburg IDM Seminar Series
Presentation by: Gwen Kettenburg
Mon 12/2/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
Wed 12/4/2019 12:00PM - 1:00PM
IDM PhD & MS Journal Club
Article - TBA IDM PhD & MS Journal Club
Article - TBA
Wed 12/4/2019 12:00PM - 1:00PM
A719 Public Health


A719 Public Health

Recent Events

IDM Dissertation Defense

Diana Campbell Delucia - PhD '18: Cellular cholesterol regulation of HIV-1 trafficking during...

Thursday 3/1 11:00AM - 1:00PM
Public Health Lecture Hall (A115)

CELLULAR CHOLESTEROL REGULATION OF HIV-1 TRAFFICKING DURING MACROPHAGE-MEDIATED TRANS INFECTION

Abstract: Professional antigen presenting cells (APC: myeloid dendritic cells (DC) and macrophages (MΦ); B lymphocytes) mediate highly efficient HIV-1 infection of CD4+ T cells, termed trans infection, that could contribute to HIV-1 pathogenesis. We have previously shown that lower cholesterol content in DC and B lymphocytes is associated with a lack of HIV-1 trans infection in HIV-1 infected nonprogressors (NP). Here we assessed whether HIV-1 trans infection mediated by another major APC, MΦ, is deficient in NP due to altered cholesterol metabolism. When comparing healthy HIV-1 seronegatives (SN), rapid progressors (PR), and NP, we found that monocyte-derived MΦ from NP did not mediate HIV-1 trans infection of autologous CD4+ T cells, in contrast to efficient trans infection mediated by SN and PR MΦ. MΦ trans infection efficiency was directly associated with the number of DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN)-expressing MΦ. Significantly fewer NP MΦ expressed DC-SIGN. Unesterified (free) cholesterol in MΦ cell membranes was significantly lower in NP than PR, as well as virus internalization in early endosomes. Furthermore, simvastatin (SIMV), decreased the subpopulation of DC-SIGN+ MΦ, as well as MΦ cis and trans infection. Notably, SIMV decreased cell membrane cholesterol and led to lipid raft dissociation, effectively mimicking the incompetent APC trans infection environment characteristic of NP. Our data support that DC-SIGN and membrane cholesterol are central to MΦ trans infection, and a lack of these limits HIV-1 disease progression. Lastly, we identified differentially expressed miRNA in NP and PR plasma which may contribute to the altered cholesterol phenotype we have identified in NP APC. Understanding the mechanisms of HIV-1 trans infection has great public health importance. For example, targeting the ability of MΦ to drive HIV-1 dissemination in trans could significantly enhance HIV-1 therapeutic strategies.

Advisor: Giovanna Rappocciolo

Last Updated On Friday, March 30, 2018 by Abby Kincaid
Created On Monday, February 26, 2018

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