IDM Events

IDM Departmental Calendar

Event Category
Mon 9/9/2019 12:00PM - 1:00PM
Open House for Undergraduates IDM Seminar Series
Open House for Undergraduates
Mon 9/9/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 9/16/2019 12:00PM - 1:00PM
Presentation by Laurie Silva, PhD IDM Seminar Series
Presentation by Laurie Silva, PhD
Mon 9/16/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Fri 9/20/2019 8:30AM - 12:00PM
35th Anniversary of the Pitt Men's Study IDM Event
35th Anniversary of the Pitt Men's Study
Fri 9/20/2019 8:30AM - 12:00PM
Public Health Auditorium (G23)


Public Health Auditorium (G23)
IDM
Event
Mon 9/30/2019 12:00PM - 1:00PM
IDM Research Day Winners IDM Seminar Series
IDM Research Day Winners
Mon 9/30/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 10/7/2019 12:00PM - 1:00PM
"TBA" IDM Seminar Series
"TBA"
Mon 10/7/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Tue 10/8/2019 9:00AM - 4:30PM
PrEP Summit: Engagement, Adherence, Retention MidAtlantic AIDS Education and Training Center Conference
PrEP Summit: Engagement, Adherence, Retention
Tue 10/8/2019 9:00AM - 4:30PM
Outside Conference and Meeting Spaces


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference
Mon 10/14/2019 12:00PM - 1:00PM
Presentation by Dustin T. Duncan, ScD IDM Seminar Series
Presentation by Dustin T. Duncan, ScD
Mon 10/14/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 10/21/2019 12:00PM - 1:00PM
Presentations by: Subramanian Thothathri & Jason Yeung IDM Seminar Series
Presentations by: Subramanian Thothathri & Jason Yeung
Mon 10/21/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Tue 10/22/2019 5:00PM - 8:30PM
Erie Evening Update: Sexual Health and Stigma MidAtlantic AIDS Education and Training Center Conference
Erie Evening Update: Sexual Health and Stigma
Tue 10/22/2019 5:00PM - 8:30PM
Outside Conference and Meeting Spaces

This evening dinner update, in collaboration with the Erie Department of Health and Erie HIV Task Force, will be held at the Bayfront Convention Center.  The presenters will discuss Sexual Health History Taking and Sexual Health and Stigma, followed by a panel of local providers.


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference
Mon 10/28/2019 12:00PM - 1:00PM
Presentations by: Byron Chuan & Zachary Koenig IDM Seminar Series
Presentations by: Byron Chuan & Zachary Koenig
Mon 10/28/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/4/2019 12:00PM - 1:00PM
Presentation by Mari Webel, PhD IDM Seminar Series
Presentation by Mari Webel, PhD
Mon 11/4/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/11/2019 12:00PM - 1:00PM
Presentations by: Emily Olsen & Karsen Shoger IDM Seminar Series
Presentations by: Emily Olsen & Karsen Shoger
Mon 11/11/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/18/2019 12:00PM - 1:00PM
Presentations by: Victoria Gould & Katrina Stephenson IDM Seminar Series
Presentations by: Victoria Gould & Katrina Stephenson
Mon 11/18/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 12/2/2019 12:00PM - 1:00PM
Presentation by: Gwen Kettenburg IDM Seminar Series
Presentation by: Gwen Kettenburg
Mon 12/2/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series

Recent Events

IDM Master's Defense

Marilee Clunk - MS Defense

Monday 6/19 11:00AM - 1:00PM
A425 Public Health

SIGLEC-10, CD1B, AND PALLADIN ARE DIFFERENTIALLY EXPRESSED BETWEEN HIV+ PROGRESSORS AND NONPROGRESSORS

Description of the problem and objectives: HIV plasma viremia and CD4+ lymphocyte counts dictate the classification of HIV+ disease progression to Acquired Immunodeficiency Syndrome (AIDS), i.e. progressor (PR) vs. non-progressor (NP). In the absence of HAART, NP CD4+ counts remain stable and viral load is substantially reduced. Recent data affirms that NPs exhibit decreased trans-infection efficiency due to reduced cholesterol levels1. Further transcriptome analysis of Multicenter AIDS Cohort Study (MACS) antigen presenting cells (APCs) reveals vastly different expression profiles between NPs and PRs for Siglec-10, CD1B, and Palladin (PALLD). While the explicit mechanism remains elusive, our aim is to elucidate the genetic origin of NP viremic control. We have hypothesized that Siglec-10, CD1b, and Palladin are differentially expressed between HIV+ PRs and NPs. 

Methods used: MACS CD14+ monocytes were cultured with IL-4 and GM-CSF to yield immature dendritic cells (iDCs). Protein expression of Siglec-10, CD1B, and PALLD in seronegative (SN), PR, and NP iDCs has been assessed using flow cytometry. RT-qPCR and TaqMan® genotyping assays in iDCs are used for corroboration of gene expression data from the transcriptome findings. 

Results: Flow cytometry data show no significant difference in Siglec-10, CD1b, or PALLD protein expression between PR and NP donors. RT-qPCR SyBr green primers for all targeted genes resulted in artefactual amplicons for control and experimental melt curves. Comparison of CT values could not be interpreted confidently. IDT Taq-Man® primers were subsequently utilized. Analysis of qPCR data shows significant differences in CD1b and PALLD expression levels between NPs and PRs (p < 0.05). Haplotype analysis of CD1b Single Nucleotide Polymorphisms (SNPs) between NP, PRs, and SN individuals via TaqMan Genotyping was not statistically significant. 

Public Health Significance: Identifying the underlying genetic factors that drive HIV-1 disease progression could reveal potential therapeutic targets with the long term aim of improving HIV health outcomes.

Last Updated On Friday, June 16, 2017 by Abby Kincaid
Created On Friday, June 16, 2017

JulAugust 2019Sep
SunMonTueWedThuFriSat
28293031123
45678910
11121314151617
18192021222324
25262728293031
1234567

Submit events and news

Enter upcoming calendar events or share your school news and announcements at publichealth.pitt.edu/submit.