IDM Events

IDM Departmental Calendar

Event Category
Mon 9/9/2019 12:00PM - 1:00PM
Open House for Undergraduates IDM Seminar Series
Open House for Undergraduates
Mon 9/9/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 9/16/2019 12:00PM - 1:00PM
Presentation by Laurie Silva, PhD IDM Seminar Series
Presentation by Laurie Silva, PhD
Mon 9/16/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Fri 9/20/2019 8:30AM - 12:00PM
35th Anniversary of the Pitt Men's Study IDM Event
35th Anniversary of the Pitt Men's Study
Fri 9/20/2019 8:30AM - 12:00PM
Public Health Auditorium (G23)


Public Health Auditorium (G23)
IDM
Event
Mon 9/30/2019 12:00PM - 1:00PM
IDM Research Day Winners IDM Seminar Series
IDM Research Day Winners
Mon 9/30/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 10/7/2019 12:00PM - 1:00PM
"TBA" IDM Seminar Series
"TBA"
Mon 10/7/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Tue 10/8/2019 9:00AM - 4:30PM
PrEP Summit: Engagement, Adherence, Retention MidAtlantic AIDS Education and Training Center Conference
PrEP Summit: Engagement, Adherence, Retention
Tue 10/8/2019 9:00AM - 4:30PM
Outside Conference and Meeting Spaces


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference
Mon 10/14/2019 12:00PM - 1:00PM
Presentation by Dustin T. Duncan, ScD IDM Seminar Series
Presentation by Dustin T. Duncan, ScD
Mon 10/14/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 10/21/2019 12:00PM - 1:00PM
Presentations by: Subramanian Thothathri & Jason Yeung IDM Seminar Series
Presentations by: Subramanian Thothathri & Jason Yeung
Mon 10/21/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Tue 10/22/2019 5:00PM - 8:30PM
Erie Evening Update: Sexual Health and Stigma MidAtlantic AIDS Education and Training Center Conference
Erie Evening Update: Sexual Health and Stigma
Tue 10/22/2019 5:00PM - 8:30PM
Outside Conference and Meeting Spaces

This evening dinner update, in collaboration with the Erie Department of Health and Erie HIV Task Force, will be held at the Bayfront Convention Center.  The presenters will discuss Sexual Health History Taking and Sexual Health and Stigma, followed by a panel of local providers.


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference
Mon 10/28/2019 12:00PM - 1:00PM
Presentations by: Byron Chuan & Zachary Koenig IDM Seminar Series
Presentations by: Byron Chuan & Zachary Koenig
Mon 10/28/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/4/2019 12:00PM - 1:00PM
Presentation by Mari Webel, PhD IDM Seminar Series
Presentation by Mari Webel, PhD
Mon 11/4/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/11/2019 12:00PM - 1:00PM
Presentations by: Emily Olsen & Karsen Shoger IDM Seminar Series
Presentations by: Emily Olsen & Karsen Shoger
Mon 11/11/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/18/2019 12:00PM - 1:00PM
Presentations by: Victoria Gould & Katrina Stephenson IDM Seminar Series
Presentations by: Victoria Gould & Katrina Stephenson
Mon 11/18/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 12/2/2019 12:00PM - 1:00PM
Presentation by: Gwen Kettenburg IDM Seminar Series
Presentation by: Gwen Kettenburg
Mon 12/2/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series

Recent Events

IDM Master's Defense

Pranali Ravikumar "Programming Dendritic Cells for Intercellular Delivery of T-bet ..."

Tuesday 4/18 11:00AM - 12:00PM
Public Health Lecture Hall (A115)

"Programming Dendritic Cells

for Intercellular Delivery of T-bet

to Enhance Function of Cytotoxic T Cells"

Abstract:  Advances in antiretroviral therapy (ART) have proven successful for controlling HIV-1 in chronically infected individuals. Despite these advancements, curing HIV-1 infection poses a major public health challenge due to the establishment and maintenance of HIV-1 latency in long lasting memory CD4+ T cells during ART. Moreover, the cytotoxic T cells (CTL) needed to effectively target and kill infected cells often become exhausted because of chronic activation. Interestingly, CTL from HIV elite controllers show less evidence exhaustion, which is also associated with higher levels of expression of the Th1-associated transcription factor T-bet.  In this study, we hypothesize that type-1 polarized human dendritic cells (DC1) are superior in their capacity to induce and enhance cellular immune responses against virally infected cells partially due to their capacity to express and transfer DC-derived T-bet to effector T cells.  Moreover, we propose that overexpression of T-bet in therapeutic DC, through genetic modification, offers another approach to improve DC-induced cellular immunity.  Here we show that DC1 indeed uniquely express T bet as a general trait while conventional DC generated in the presence of PGE2 (DC2) are T-bet deficient as determined by western blot and intracellular flow cytometry analysis.  We also report that overexpression of T-bet in DC1 (DC1Tbet) through use of an adenoviral vector delivery system enhances their CTL inducing activity. However, DC1Tbet display a reduction in their capacity to produce IL-12p70 upon activation with CD40L. Moreover, using a GFP-based tracking method, we demonstrate that DC1 have the capacity to directly transfer cytoplasmic content to activated CD8+ T cells in a CD40L dependent manner.  These data suggest, both a novel helper function of CD40L expressing CD4+ Th cells, and a mechanism for potential DC to T cell transfer of T-bet.  We propose that this immune mechanism of DC1 to CTL intercellular transfer can be exploited to enhance anti-HIV T cell response, or to correct their dysfunction of T cell exhaustion as supported by evidence in DC1-based cancer immunotherapy studies.


Last Updated On Thursday, April 27, 2017 by Malenka, Judith Ann
Created On Monday, April 10, 2017

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