IDM Events

IDM Departmental Calendar

Event Category
Fri 9/20/2019 8:30AM - 12:00PM
35th Anniversary of the Pitt Men's Study IDM Event
35th Anniversary of the Pitt Men's Study
Fri 9/20/2019 8:30AM - 12:00PM
Public Health Auditorium (G23)


Public Health Auditorium (G23)
IDM
Event
Tue 10/8/2019 9:00AM - 4:30PM
PrEP Summit: Engagement, Adherence, Retention MidAtlantic AIDS Education and Training Center Conference
PrEP Summit: Engagement, Adherence, Retention
Tue 10/8/2019 9:00AM - 4:30PM
Outside Conference and Meeting Spaces


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference
Tue 10/22/2019 5:00PM - 8:30PM
Erie Evening Update: Sexual Health and Stigma MidAtlantic AIDS Education and Training Center Conference
Erie Evening Update: Sexual Health and Stigma
Tue 10/22/2019 5:00PM - 8:30PM
Outside Conference and Meeting Spaces

This evening dinner update, in collaboration with the Erie Department of Health and Erie HIV Task Force, will be held at the Bayfront Convention Center.  The presenters will discuss Sexual Health History Taking and Sexual Health and Stigma, followed by a panel of local providers.


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference

Recent Events

IDM Master's Defense

Joe Albe, "Viral Encephalitis: Phenotyping Leukocyte Infiltration ..."

Thursday 4/13 1:00PM - 2:00PM
A425 Public Health

"Viral Encephalitis:  Phenotyping Leukocyte Infiltration
into the Central Nervous System as a
Result of Rift Valley Fever Virus Infection"

Abstract:  Rift Valley Fever Virus (RVFV) is a vector-borne infection endemic to the Horne of Africa; However, 2001 outbreaks in the Arabian Peninsula demonstrate its expanding range. Humans can develop encephalitis as a result of RVFV infection. Our lab uses an immunocompetent Lewis rat model to study neuropathogenesis of RVFV, which uniformly develop lethal encephalitis within 7 – 8 days after aerosol exposure. Lewis rats infected subcutaneously do not develop apparent disease. The goal of this study is to characterize the phenotypes, timing, and extent of immune cell infiltrate into the CNS of RVFV-infected Lewis rats. Lewis rats were infected with RVFV ZH501 by aerosol or subcutaneous routes, and subsequently serial sacrificed between 1 and 7 days post infection. Rat immune cells were isolated from brains via percoll gradients, were stained with the appropriate antibodies, run on a BD LSRII flow cytometer, and analyzed with FlowJo 7.6.5.

In aerosol infected rats, the leukocyte infiltrate 5 days post infection and later, consisted of primarily neutrophils, corresponding to the clinical window. Rats infected subcutaneously had detectable infiltrate, despite no apparent disease, which primarily consisted of phenotypic CD4+ T cells. These findings suggest that aerosol infected rats mainly exhibit innate leukocyte infiltration to the brain while subcutaneous have limited leukocyte infiltration and display a stronger adaptive immune response. The relative contributions of viral cytopathology versus immunopathology remain to be determined, but this study represent the first attempt to characterize the leukocytic component of RVFV infection.

 

 


Last Updated On Wednesday, May 03, 2017 by Malenka, Judith Ann
Created On Monday, April 10, 2017

JulAugust 2019Sep
SunMonTueWedThuFriSat
28293031123
45678910
11121314151617
18192021222324
25262728293031
1234567

Submit events and news

Enter upcoming calendar events or share your school news and announcements at publichealth.pitt.edu/submit.