IDM Events

IDM Departmental Calendar

Event Category
Mon 9/9/2019 12:00PM - 1:00PM
Open House for Undergraduates IDM Seminar Series
Open House for Undergraduates
Mon 9/9/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 9/16/2019 12:00PM - 1:00PM
Presentation by Laurie Silva, PhD IDM Seminar Series
Presentation by Laurie Silva, PhD
Mon 9/16/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Fri 9/20/2019 8:30AM - 12:00PM
35th Anniversary of the Pitt Men's Study IDM Event
35th Anniversary of the Pitt Men's Study
Fri 9/20/2019 8:30AM - 12:00PM
Public Health Auditorium (G23)


Public Health Auditorium (G23)
IDM
Event
Mon 9/30/2019 12:00PM - 1:00PM
IDM Research Day Winners IDM Seminar Series
IDM Research Day Winners
Mon 9/30/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 10/7/2019 12:00PM - 1:00PM
"TBA" IDM Seminar Series
"TBA"
Mon 10/7/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Tue 10/8/2019 9:00AM - 4:30PM
PrEP Summit: Engagement, Adherence, Retention MidAtlantic AIDS Education and Training Center Conference
PrEP Summit: Engagement, Adherence, Retention
Tue 10/8/2019 9:00AM - 4:30PM
Outside Conference and Meeting Spaces


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference
Mon 10/14/2019 12:00PM - 1:00PM
Presentation by Dustin T. Duncan, ScD IDM Seminar Series
Presentation by Dustin T. Duncan, ScD
Mon 10/14/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 10/21/2019 12:00PM - 1:00PM
Presentations by: Subramanian Thothathri & Jason Yeung IDM Seminar Series
Presentations by: Subramanian Thothathri & Jason Yeung
Mon 10/21/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Tue 10/22/2019 5:00PM - 8:30PM
Erie Evening Update: Sexual Health and Stigma MidAtlantic AIDS Education and Training Center Conference
Erie Evening Update: Sexual Health and Stigma
Tue 10/22/2019 5:00PM - 8:30PM
Outside Conference and Meeting Spaces

This evening dinner update, in collaboration with the Erie Department of Health and Erie HIV Task Force, will be held at the Bayfront Convention Center.  The presenters will discuss Sexual Health History Taking and Sexual Health and Stigma, followed by a panel of local providers.


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference
Mon 10/28/2019 12:00PM - 1:00PM
Presentations by: Byron Chuan & Zachary Koenig IDM Seminar Series
Presentations by: Byron Chuan & Zachary Koenig
Mon 10/28/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/4/2019 12:00PM - 1:00PM
Presentation by Mari Webel, PhD IDM Seminar Series
Presentation by Mari Webel, PhD
Mon 11/4/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/11/2019 12:00PM - 1:00PM
Presentations by: Emily Olsen & Karsen Shoger IDM Seminar Series
Presentations by: Emily Olsen & Karsen Shoger
Mon 11/11/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/18/2019 12:00PM - 1:00PM
Presentations by: Victoria Gould & Katrina Stephenson IDM Seminar Series
Presentations by: Victoria Gould & Katrina Stephenson
Mon 11/18/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 12/2/2019 12:00PM - 1:00PM
Presentation by: Gwen Kettenburg IDM Seminar Series
Presentation by: Gwen Kettenburg
Mon 12/2/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series

Recent Events

IDM Master's Defense

Hawa Mariko, "Medroxyprogesterone Acetate has Minimal Impact on HIV-1 Replication..."

Friday 4/14 1:00PM - 2:00PM
A425 Public Health

"Medroxyprogesterone Acetate has

Minimal Impact on HIV-1 Replication

in Ectocervical Tissue Ex Vivo"

 

Abstract:  The link between depomedroxyprogesterone acetate use and risk of HIV-1 acquisition has been demonstrated in epidemiologic studies. Peak medroxyprogesterone-17-acetate (MPA) levels occur 4 days post-injection with serum progestin levels of 2 nM. Our hypothesis is physiologic concentrations of MPA will not affect HIV replication in ectocervical tissue ex vivo.

 

Ectocervical tissue was processed into polarized explants. Explants were cultured alone (control) or with MPA in the basolateral compartment at physiological (0.05nM, 0.5nM, 1nM, 5nM) (n=17) or higher concentrations (500nM, 5µM, 500µM) (n=10) for 48 h, infected with either 5x10or 5x103 TCID50  HIV-1BaL apically for 24 h, and then washed. Basolateral supernatants were collected and replenished with fresh medium containing MPA every 3-4 days up to 21 days. Supernatant collections at the 48 h time point (pre-infection) were tested for cytokine expression while all following supernatant collections post-infection were analyzed for viral p24gag (pg/ml).

 

Viral growth over 21 days for supraphysiologic concentrations indicated suppression, while that for physiologic concentrations was not significantly different from the control. Cytokine   marke evaluation   indicated   a   hormone   dose-dependent   relationship   between decreasing MPA concentrations (500µM-5nM) and increasing expression of pro-inflammatory cytokines approaching levels of the control, significant for IL-12 (p40), IL6, and IL-8.

 

MPA does not significantly impact HIV-1 replication at physiologic concentrations but ha a overall suppressive effect on replication at supraphysiologic concentrations in ectocervical tissue in cervical tissue ex vivo.

 

The public health significance of DMPA continuation requires balancing unintended pregnancy while diminishing HIV acquisition risk, especially when the risks of infection do not outweigh the contraceptive benefits.

 

 

 

Last Updated On Wednesday, May 03, 2017 by Malenka, Judith Ann
Created On Friday, April 07, 2017

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