IDM Events

IDM Departmental Calendar

Event Category
Mon 9/9/2019 12:00PM - 1:00PM
Open House for Undergraduates IDM Seminar Series
Open House for Undergraduates
Mon 9/9/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 9/16/2019 12:00PM - 1:00PM
Presentation by Laurie Silva, PhD IDM Seminar Series
Presentation by Laurie Silva, PhD
Mon 9/16/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Fri 9/20/2019 8:30AM - 12:00PM
35th Anniversary of the Pitt Men's Study IDM Event
35th Anniversary of the Pitt Men's Study
Fri 9/20/2019 8:30AM - 12:00PM
Public Health Auditorium (G23)


Public Health Auditorium (G23)
IDM
Event
Mon 9/30/2019 12:00PM - 1:00PM
IDM Research Day Winners IDM Seminar Series
IDM Research Day Winners
Mon 9/30/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 10/7/2019 12:00PM - 1:00PM
"TBA" IDM Seminar Series
"TBA"
Mon 10/7/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Tue 10/8/2019 9:00AM - 4:30PM
PrEP Summit: Engagement, Adherence, Retention MidAtlantic AIDS Education and Training Center Conference
PrEP Summit: Engagement, Adherence, Retention
Tue 10/8/2019 9:00AM - 4:30PM
Outside Conference and Meeting Spaces


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference
Mon 10/14/2019 12:00PM - 1:00PM
Presentation by Dustin T. Duncan, ScD IDM Seminar Series
Presentation by Dustin T. Duncan, ScD
Mon 10/14/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 10/21/2019 12:00PM - 1:00PM
Presentations by: Subramanian Thothathri & Jason Yeung IDM Seminar Series
Presentations by: Subramanian Thothathri & Jason Yeung
Mon 10/21/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Tue 10/22/2019 5:00PM - 8:30PM
Erie Evening Update: Sexual Health and Stigma MidAtlantic AIDS Education and Training Center Conference
Erie Evening Update: Sexual Health and Stigma
Tue 10/22/2019 5:00PM - 8:30PM
Outside Conference and Meeting Spaces

This evening dinner update, in collaboration with the Erie Department of Health and Erie HIV Task Force, will be held at the Bayfront Convention Center.  The presenters will discuss Sexual Health History Taking and Sexual Health and Stigma, followed by a panel of local providers.


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference
Mon 10/28/2019 12:00PM - 1:00PM
Presentations by: Byron Chuan & Zachary Koenig IDM Seminar Series
Presentations by: Byron Chuan & Zachary Koenig
Mon 10/28/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/4/2019 12:00PM - 1:00PM
Presentation by Mari Webel, PhD IDM Seminar Series
Presentation by Mari Webel, PhD
Mon 11/4/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/11/2019 12:00PM - 1:00PM
Presentations by: Emily Olsen & Karsen Shoger IDM Seminar Series
Presentations by: Emily Olsen & Karsen Shoger
Mon 11/11/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 11/18/2019 12:00PM - 1:00PM
Presentations by: Victoria Gould & Katrina Stephenson IDM Seminar Series
Presentations by: Victoria Gould & Katrina Stephenson
Mon 11/18/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series
Mon 12/2/2019 12:00PM - 1:00PM
Presentation by: Gwen Kettenburg IDM Seminar Series
Presentation by: Gwen Kettenburg
Mon 12/2/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)


Public Health Lecture Hall (A115)
IDM
Seminar Series

Recent Events

IDM Master's Defense

Julie Laux - MPH-PEL Defense

Thursday 4/20 8:30AM - 9:30AM
Conference Room 2140 Parran Hall

"CCR5 Antagonists Used as

Topical Microbicides Modulate CCR5 Expression

and May Compound HIV Infection"


Abstract:  CCR5 antagonists, such as Maraviroc (MVC) and 5P12-RANTES, are being evaluated as HIV preventatives. Their advantage is they restrict HIV entry via CCR5 receptor. However, sub-clinical concentrations could paradoxically increase HIV risk by increasing CCR5 expression.

Peripheral blood mononuclear cells (PBMCs) and cervical tissue were cultured with one HIV antiretrovirals (ARVs), Maraviroco (MVC), 5P12-RANTES, dapivirine (DPV), or griffithsin (GRFT).  PBMCs/cervical tissue’s isolated immune cells were stained with live/dead stain and monoclonal antibodies. Samples were analyzed using a BD LSRII flow cytometer and FlowJo v. 10.1 software. To determine if suboptimal concentrations of ARVs influence HIV susceptibility, PBMCs/cervical tissue were treated with MVC, 5P12-RANTES, DPV, or GRFT and challenged with HIV-1BaL.  Supernatant was collected on days 3, 7, and 11 then tested for viral p24 by the AlphaLISA.

In PBMCs,
10 nM and 1nM MVC induced greater CCR5+ expression when compared to DPV or GRFT treated cells, respectively. No drug concentrations had a significant increase in percent positive CCR5+CD4+ cells. There were no significant changes in CCR5 MFI or percent positive cells found in the cervical tissue.  HIV replication, via p24 production, did not increase for any drug concentration in PBMCs, but 975nM MVC significantly increased p24 expression in cervical tissue.

MVC is an effective therapeutics for HIV-infected persons, but may be problematic for HIV prevention due to its dose and time dependent qualities. Likewise, 5P12-RANTES showed similar trends in CCR5 expression. Topical application of CCR5 antagonists may be effective for only a short period in the genital tract. Conversely, DPV and GRFT did not affect CCR5 expression. The use of CCR5 antagonists for HIV prevention should be reconsidered as other options become available.  The public health impact of improving topical HIV drugs would reduce global HIV prevalence and shift toward an HIV-free world.
   

Last Updated On Friday, April 07, 2017 by Malenka, Judith Ann
Created On Friday, April 07, 2017

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