This evening dinner update, in collaboration with the Erie Department of Health and Erie HIV Task Force, will be held at the Bayfront Convention Center. The presenters will discuss Sexual Health History Taking and Sexual Health and Stigma, followed by a panel of local providers.
Abstract: The New World Alphaviruses Eastern Equine Encephalitis virus (EEEV), Venezuelan Equine Encephalitis virus (VEEV), and Western Equine Encephalitis virus (WEEV) are all mosquito-borne pathogens originating in North and South America. All three viruses are capable of causing severe illness in animals and humans, with extreme cases leading to encephalitis. Given the lack of commercially available vaccines or treatments, and previous research into these pathogens as potential bioterrorism weapons, the aim of our laboratory was to develop a cynomolgus macaque model to study the unique neuropathology of each virus when delivered via an aerosol route. To assess pathogenesis, PBMCs were isolated from whole blood and analyzed by flow cytometry. Inflammation in the CNS was also evaluated using a LEGENDplex bead based immunological array. Results indicate a substantial increase in the number of CCR2+ myeloid cells in circulation, a receptor important for brain homing and migration. In addition, inflammatory cytokines MCP-1, IP-10, IL-6, and IL-8 were substantially upregulated in the CNS tissues and CSF of lethally infected animals.
Last Updated On Wednesday, April 26, 2017 by Borkowski, Matthew Gerard
Created On Thursday, April 06, 2017