IDM Events

IDM Departmental Calendar

Event Category
Fri 9/20/2019 8:30AM - 12:00PM
35th Anniversary of the Pitt Men's Study IDM Event
35th Anniversary of the Pitt Men's Study
Fri 9/20/2019 8:30AM - 12:00PM
Public Health Auditorium (G23)


Public Health Auditorium (G23)
IDM
Event
Tue 10/8/2019 9:00AM - 4:30PM
PrEP Summit: Engagement, Adherence, Retention MidAtlantic AIDS Education and Training Center Conference
PrEP Summit: Engagement, Adherence, Retention
Tue 10/8/2019 9:00AM - 4:30PM
Outside Conference and Meeting Spaces


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference
Tue 10/22/2019 5:00PM - 8:30PM
Erie Evening Update: Sexual Health and Stigma MidAtlantic AIDS Education and Training Center Conference
Erie Evening Update: Sexual Health and Stigma
Tue 10/22/2019 5:00PM - 8:30PM
Outside Conference and Meeting Spaces

This evening dinner update, in collaboration with the Erie Department of Health and Erie HIV Task Force, will be held at the Bayfront Convention Center.  The presenters will discuss Sexual Health History Taking and Sexual Health and Stigma, followed by a panel of local providers.


Outside Conference and Meeting Spaces
MidAtlantic AIDS Education and Training Center
Conference

Recent Events

IDM Master's Defense

Hong Liu - MS Defense

Thursday 4/20 12:00PM - 1:00PM
Public Health Lecture Hall (A115)

"Glucose Transporter Expression in

Lung Granulomas from

Mycobacterium Tuberculosis-Infected Monkeys"

Abstract:  Tuberculosis (TB) remains a major threat to public health that causes tremendous morbidity and mortality in developing countries. The diagnostic tests for TB have problems with sensitivity, specificity, and ability to measure treatment outcomes. Positron emission tomography/computed tomography (PET/CT) imaging techniques can provide a fast and sensitive way of diagnosing active TB and can be a valuable tool of studying TB-associated inflammation in tissues. The most common PET probe is FDG, a glucose analog that is taken up by metabolically active cells, but the factors driving FDG uptake and the cells responsible for this in granulomas remain unknown. Our study focused on expression of glucose transporters (Gluts), a diverse set of proteins involved in glucose metabolism, in granulomas from Mycobacterium tuberculosis-infected monkeys. Our objective was to measure Glut expression, localization, and cellular source. We used RT-PCR and multi-color immunohistochemistry to accomplish this objective. We found that there was substantial variation in Glut expression between granulomas and uninfected lung, and that expression of individual Gluts did not correlate with FDG uptake in tissues. Our immunohistochemical studies demonstrated that Glut1 and 3 were strongly expressed by epithelioid macrophages, a cell type that exists in hypoxic environments and is likely to be using glycolysis to generate energy. We also identified a correlation between neutrophils and FDG uptake, suggesting these cells may contribute to PET/CT-measured inflammation in granulomas. Our results suggest that multiple factors, rather than a single Glut, drive FDG uptake in granulomas, but also indicate Glut expression on specific cell populations may strongly influence PET/CT detection of TB. Future work identifying the relationship between these cell populations and changes in FDG uptake over the course of disease may lead to important new information on pathogenesis in TB.

 

 

Last Updated On Thursday, April 06, 2017 by Malenka, Judith Ann
Created On Thursday, April 06, 2017

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