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Noon Seminar Series

Human Genetics noon seminar series

The Human Genetics Seminar Series has a new location and will be held on Fridays from 12 - 1 in A115 Public Health. Exceptions to this time and/or place are noted in the schedule below.

Upcoming

Fri 2/22/2019 12:00PM - 1:00PM
TBD
Public Health Lecture Hall (A115)

Fri 3/1/2019 12:00PM - 1:00PM
TBD
Public Health Lecture Hall (A115)

Fri 3/8/2019 12:00PM - 1:00PM
Michael Pogue-Geile - Schizophrenia and Endophenotypes
Public Health Lecture Hall (A115)

Fri 4/5/2019 12:00PM - 1:00PM
Grand Rounds CC Li Lecture
Public Health Lecture Hall (A115)

The Department of Human Genetics holds an annual guest lecture in honor of former faculty member Ching Chun "C.C." Li, Pitt Public Health faculty for over 30 years, former chair of the Department of Biostatistics, and celebrated statistician and geneticist. Stay tuned for more information about this year's lecture. 

Fri 4/19/2019 12:00PM - 1:00PM
TBD
Public Health Lecture Hall (A115)

Previous

Fri 2/15/2019
Advances in molecular biology – rapidly reshaping cancer treatment Human Genetics Seminar Series
Advances in molecular biology – rapidly reshaping cancer treatment
Fri 2/15/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)

Fri 2/1/2019
Svetlana Yatsenko - The secrets of the X chromosome Human Genetics Seminar Series
Svetlana Yatsenko - The secrets of the X chromosome
Fri 2/1/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)

Fri 1/25/2019
Toren Finkel - Mitochondria, metabolism and aging Human Genetics Seminar Series
Toren Finkel - Mitochondria, metabolism and aging
Fri 1/25/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)

Fri 1/18/2019
John Shaffer - The genetic architecture of human facial morphology Human Genetics Seminar Series
John Shaffer - The genetic architecture of human facial morphology
Fri 1/18/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)

John Shaffer, PhD - The genetic architecture of human facial morphology

Fri 1/11/2019
Novel therapies for inborn errors of metabolism of fatty acid oxidation: A personalized medicine ap Human Genetics Seminar Series
Novel therapies for inborn errors of metabolism of fatty acid oxidation: A personalized medicine ap
Fri 1/11/2019 12:00PM - 1:00PM
Public Health Lecture Hall (A115)

Inborn errors of energy metabolism are among the most common inherited disorders affecting ~1:5,000 people in the US. Three mitochondrial metabolic pathways are required for efficient energy production in eukaryotic cells – the electron transfer chain (ETC), fatty acid b-oxidation (FAO), and the tricarboxylic acid (TCA) cycle. The ETC is organized into inner mitochondrial membrane supercomplexes that promote substrate channeling and catalytic efficiency. While previous studies have suggested functional interaction between FAO and the ETC, their physical interaction had never been demonstrated. Studies in the Vockley lab have now shown for the first time that FAO enzymes physically interact with electron transfer chain supercomplexes at two points. The FAO trifunctional protein interacts with the NADH-binding domain of complex I of the ETC, while electron transfer flavoprotein dehydrogenase interacts with ETC complex III. In addition, the FAO enzyme very long chain acyl-CoA dehydrogenase (VLCAD) physically interacts with TFP, thus creating a multi-functional energy protein complex. These findings provide first view of an integrated molecular architecture for the major energy generating pathways in mitochondria that ensures the safe transfer of unstable reducing equivalents from FAO to the ETC. The impact of these findings on understanding the pathophysiology of inborn errors of energy metabolism, and the development of novel therapeutic agents based on patient specific bioenergetic and genetic characteristics will be presented.

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Questions/Comments

For questions, comments or to edit/update any of these events please contact Ryan Evans and Mike Singer
© 2019 by University of Pittsburgh Graduate School of Public Health

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