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Zhentai Huang, PhD

Research Instructor, Environmental and Occupational Health

Contact

100 Technology Drive, Bridgeside Point I/EOH, Pittsburgh, PA 15219
R-znvy: muu1@cvgg.rqh
Primary Phone: 967-179-4929


Personal Statement

My research interest is focused on searching new compounds that can mitigate and/or treat the short- and long-term consequences of severe irradiation exposure such as radiological/nuclear terrorist event. Though irradiation directly induces serious damage to rapidly proliferating cells, the subsequent mechanisms of damage seem to be triggered by secondary responses whereby inflammatory cytokines, chemotactic factors and lipid mediators are the major players. More and more evidences showed that cells were damaged by irradiation directly or indirectly through necroptotic pathway. Lipids were reported to play an important role during necroptosis. My goal is to find lipid mediators during primary or secondary irradiation induced necroptosis, and search new compounds protect cells from damage by blocking the lipid mediators' signaling pathway.


Education

2005 | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing, China | PhD in Pharmacognosy
1996 | Shandong University, China | Bachelor of Science in Microbiology



Selected Publications

  1. Jiang J, Bakan A, Kapralov AA, Ishara Silva K, Huang Z, Amoscato AA, Peterson J, Krishna Garapati V, Saxena S, Bayir H, Atkinson J, Bahar I, Kagan VE. (2014) Designing inhibitors of cytochrome c/cardiolipin peroxidase complexes: mitochondria-targeted imidazole-substituted fatty acids. Free Radical Biology & Medicine. 71:221-230.
  2. Chu CT, Ji J, Dagda RK, Jiang JF, Tyurina YY, Kapralov AA, Tyurin VA, Yanamala N, Shrivastava IH, Mohammadyani D, Qiang Wang KZ, Zhu J, Klein-Seetharaman J, Balasubramanian K, Amoscato AA, Borisenko G, Huang Z, Gusdon AM, Cheikhi A, Steer EK, Wang R, Baty C, Watkins S, Bahar I, Bayir H, Kagan VE. (2013) Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nature Cell Biology. 15(10):1197-1205.
  3. Huang Z, Jiang J, Belikova NA, Stoyanovsky DA, Kagan VE, Mintz AH. (2010) Protection of normal brain cells from γ-irradiation-induced apoptosis by a mitochondria-targeted triphenyl-phosphonium-nitroxide: a possible utility in glioblastoma therapy. J Neurooncol. 100(1):1-8.
  4. Huang Z, Jiang J, Tyurin VA, Zhao Q, Mnuskin A, Ren J, Belikova NA, Feng W, Kurnikov IV, Kagan VE. (2008) Cardiolipin deficiency leads to decreased cardiolipin peroxidation and increased resistance of cells to apoptosis. Free Radic Biol Med 44(11):1935-1944.

Zhentai  Huang
© 2017 by University of Pittsburgh Graduate School of Public Health

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