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Yong Seok Park, PhD

Assistant Professor, Biostatistics

Contact

7138 Parran
R-znvy: lbatcnex@cvgg.rqh
Primary Phone: 967-179-8573
Fax: 967-179-7638


Personal Statement

My current research focuses on epigenetic and high throughput genomic data analysis in cancer study. Since January 2012, I have focused on Bioinformatics research such as developing whole genome DNA methylation data analysis pipeline using novel statistical model, RNA sequencing data analysis, microarray and sequencing based gene expression data analysis. In addition, I have developed a web-based statistical tool to predict recurrence of prostate cancer for patients after radiation therapy using Bayesian joint survival-longitudinal modeling. My research interests also include other traditional Biostatistics research including survival analysis, nonparametric analysis and ordered statistics analysis.


Education

2011 | University of Michigan-Ann Arbor | Ph.D.
2007 | University of Michigan-Ann Arbor | Master of Science
Tsinghua University, Beijing P.R.China | Master of Engineering 
Shanghai Jiao Tong University, Shanghai P.R.China | Bachelor of Engineering


Teaching

BIOST 2083, Linear Models, Fall 2014

BIOST 2083, Linear Models, Fall 2015
BIOST 2083, Linear Models, Fall 2016

BIOST 2025, Biostatistics Seminar, Fall 2014  

BIOST 2025, Biostatistics Seminar, Winter 2015  

BIOST 2025, Biostatistics Seminar, Fall 2015


Selected Publications

  1. Machicado JD, Gougol A, Stello K, Tang G, Park Y, Slivka A, Whitcomb DC, Yadav D,
    Papachristou GI. (2017)  Acute Pancreatitis Has a Long-Term Deleterious Effect on Physical Quality of Life. Clin Gastroenterol Hepatol,S1542-3565(17)30668-7. 
  2. Seynnaeve, B., Lee, S., Borah, S., Park, Y., Pappo, A., Kirkwood, J. M., Bahrami, A. (2017). Genetic and Epigenetic Alterations of TERT Are Associated with Inferior Outcome in Adolescent and Young Adult Patients with Melanoma. Scientific Reports, 7, 45704
  3. Xu Z, Zhen B, Park Y, Zhu B,(2017) Designing therapeutic cancer vaccine trials with delayed treatment effect. Statistics in medicine, 36,592-605
  4. Kim S, Oesterreich S, Kim S, Park Y, Tseng GC.,(2017) Integrative Clustering of Multi-level Omics Data for Disease Subtype Discovery using Sequential Double Regularization. Biostatistics (Oxford, England) , 18,165-179
  5. Andersen, C.L., Sikora, M.J., Boisen, M.M., Ma, T., Christie, A., Tseng, G., Park, Y.S., Luthra, S., Chandran, U., Haluska, P., Mantia-Smaldone, G.(2017)  Active estrogen receptor-alpha signaling in ovarian cancer models and clinical specimens. Clinical Cancer Research, 23,3802-3812.
  6. Gearhart, T. L., Montelaro, R. C., Schurdak, M. E., Pilcher, C. D., Rinaldo, C. R.,  Kodadek, T., Park, Y., Islam, K., Yurko, R., Marques, E. T. A  Jr. and Burke, D. S.(2016), Selection of a potential diagnostic biomarker for HIV infection from a random library of non-biological synthetic peptoid oligomers. Journal of immunological methods, 435,85-9.
  7. Qin, Z., Li, B., Conneely, K. N., Wu, H., Hu, M., Ayyala, D, Park, Y., Jin, V. X., Zhang, F., Zhang, H., Li,  L., Lin, S. (2.16) Statistical challenges in analyzing methylation and long-range chromosomal interaction data. Statistics in biosciences,  8,284-309.
  8. Park, Y, Wu, H.(2016) Differential methylation analysis for BS-seq data under general experimental design. Bioinformatics (Oxford, England), 32(10):1446-53.
  9. Zhang, X, Rao, A., Sette, P, Deibert, C. Pomerantz, A., Kim, W. J., Kohanbash, G, Chang, Y., Park, Y., Engh, J. Choi, J., Chan, T. Okada, H. Lotze, M. Paola, G., Amankulor, N. (2016) IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression. Neuro-oncology, 18,1402-12.
  10. Li, H, Wheeler, S, Park, Y, Ju, Z, Thomas, SM, Fichera, M, Egloff, AM, Lui, VW, Duvvuri, U, Bauman JE, Mills, GB, Grandis, JR (2016). Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts. Molecular Cancer Research, 14,278-86.
  11. Park, Y., Figueroa, M.E., Rozek, L.S., Sartor, M.A (2014). methylSig: a whole genome DNA methylation analysis pipeline. Bioinformatics, 30, 2414-22.
  12. Park, Y., Kalbfleisch, J.D. and Taylor, J.M.G (2014). Confidence intervals under order restriction. Statistica Sinica,  24, 429-445.
  13. Taylor, J.M.G., Park, Y., and others (2013), Real-time individual predictions of prostate cancer recurrence using joint  models. Biometrics, 69, 206-213.
  14. Park, Y., Taylor, J.M.G. and Kalbfleisch, J.D. (2012), Pointwise nonparametric maximum likelihood estimator of stochastically ordered survivor functions. Biometrika, 99, 327-343. (Supplementary material)
  15. Park, Y., Kalbfleisch, J.D. and Taylor, J.M.G. (2012), Constrained nonparametric maximum likelihood estimator of stochastically ordered survivor functions. Canadian Journal of Statistics, 40, 22-39.





Yong Seok  Park
© 2017 by University of Pittsburgh Graduate School of Public Health

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