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Dr. Valerian E Kagan, PhD, DSc

Professor, Environmental and Occupational Health

Contact

Environmental and Occupational Health, 100 Technology Drive, BRIDG 328, Pittsburgh, PA 15219
R-znvy: xntna@cvgg.rqh
Primary Phone: 967-179-4924
Secondary Phone: 967-179-4255
Fax: 967-179-4816
Web site:


Personal Statement

Dr. Valerian E. Kagan is one of the world’s recognized leaders and one of the most prominent authorities in the field of Free Radical Biology and Medicine.  Internationally known for his profound interdisciplinary studies of oxidative stress, antioxidants, tissue and cell acute and chronic injury, he has founded a new field of research “Oxidative Lipidomics” and demonstrated its research power in investigations of cell death mechanisms. Free radicals, lipid peroxidation and oxidative stress have been long associated with tissue and cell damage through yet not well characterized specific mechanisms.  The incompleteness of this knowledge is a stumbling block in discovery, development and effective implementation of antioxidant preventive and therapeutic strategies.  The research performed by Dr. Kagan is a breakthrough in the field as it uncovers specific pathways through
which enzymes of oxidative metabolism participate in the production of specific oxygenated lipid molecules that act as signals triggering cell death program as well as mechanisms involved in clearance of damaged or dead cells. Understanding these key signaling pathways is of prime importance for obtaining new insights into mechanisms of radiation injury, inflammation, and immune responses.  Based on the discoveries of Dr. Kagan’s lab mechanism-based approaches to
creation of novel generations of preventive, protective and mitigating small molecule drugs have been developed that are being tested in a number of conditions.


Education

1967 -  MV Lomonosov Moscow State University, Russia, BS - Biochemistry, Biophysics
1978 -  MV Lomonosov Moscow State University, Russia, MS - Biochemistry, Biophysics
1972 -  MV Lomonosov Moscow State University, Russia, PhD- Biochemistry, Biophyscis
1981 - USSR Academy of Sciences, Russia, DSc - Biochemistry, Biophysics
1983 - State Prize of the USSR for Science (in the former USSR, the top 10-15 programs in Science were 
            annual awarded this prize.
2012 - Fellow, The American Association for the Advancement of Science


Teaching

Introduction to Research Methods I and II: Instructor
Biochemical Techniques in Molecular Toxicology: Instructor
Cancer Biology and Therapeutics (Graduate Pharmacology Course Series): Lecturer
Principles of Toxicology: Lecturer
Molecular Fundamentals: Lecturer
Molecular Biophysics 2: Biomolecular Interactions and Dynamics: Lecturer


Selected Publications

Stoyanovsky DA, Sparvero LJ, Amoscato AA, He RR, Watkins S, Pitt BR, Bayir H, Kagan VE. 
Improved spatial resolution of matrix-assisted laser desorption/ionization imaging of lipids in the brain by alkylated derivatives of 2.5-dihydroxybenzoic acid.  Rapid Commun Mass Spectrom. 28(5):403-12, 2014. PMID: 24497278.

Tyurin VA, Balasubramanian K, Winnica D, Tyurina YY, Vikulina AS, He RR, Kapralov AA, Macphee CH, Kagan VE.  Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic ‘eat-me’ signals: cleavage and inhibition of phagocytosis by Lp-PLA2. Cell Death
Differ. 21(5):825-35, 2014 PMID: 24464221

Goetzman ES, Alcorn JF, Bharathi SS, Uppala R, McHugh KJ, Kosimider B, Chen R, Zuo YY, Beck ME, McKinney RW, Skilling H,Suhrie KR, Karunanidhi A, Yeasted R, Otsubo C, Ellis B, Tyurina YY, Kagan VE, Mallampalli RK, Vockley J.   Long-chain Acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction.  J Biol Chem, 289(15):10668-79, 2014 PMID: 24591516

Cao W, Ramakrishnan R, Tyurin VA, Veglia F, Condamine T, Amoscato A, Mohammadyani D, Johnson JJ, Min Zhang L, Klein-Seetharaman J, Celis E, Kagan VE, Gabrilovich DI.  Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer. J Immunol. 2014. [Epub ahead
of print] PMID: 24554775

Kagan VE, Epand RM.  Decipering the mysteries of cardiolipins in mitochondria.  Chem Phys Lipids. 179:1-2, 2014. PMID: 24365282

Chu CT, Bayir H, Kagan VE.  LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons: Implications for Parkinson disease.  Autophag. 10(2):376-378, 2014. PMID: 24351649

Tyurina YY, Domingues RM, Tyurin VA, Maciel E, Domingues P. Amoscato AA, Bayir H, Kagan VE. 
Characterization of cardiolipins and their oxidation products by LC-MS analysis.  Chem Phys Lipids. 179:3-10, 2014. PMID: 24333544

Chen BB, Coon TA, Glasser JR, Zou C, Ellis B,Das T, McKelvey AC, Rajbhandari S, Lear T, Kamga C, Shiva S, Li C, Pilewski JM,Callio J, Chu CT, Ray A, Ray P, Tyurina YY, Kagan VE, Mallampalli RK.  E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia.  Cell Rep. [Epub ahead of print], 2014. PMID:24703837

Jiang J, Bakan A. Kapralov AA, Ishara Silva K, Huang Z, Amoscato AA, Peterson J, Krishna Garapati V, Saxena S, Bayir H, Atkinson J, Bahar I, Kagan VE.  Designing inhibitors of cytochrome  c/cardiolipin
peroxidase complexes: mitochrondria-targeted imidazole-substituted fatty acids.  Free Radic Biol Med. 71C:221-230, 2014. PMID:24631490

Fabisiak JP, Borisenko GG, Kagan VE.  Quantitative Method of Measuring Phosphatidylserien Externalization During Apoptosis Using Electron Paramagnetic Resonance (EPR) Spectroscopy and Annexin-Conjugated Iron.  Methods Mol Bio. 1105:613-21, 2014. PMID: 24623356

Fabisiak JP, Tyurina YY, Tyurin VA, Kagan VE.  Quantification of selective phosphatidylserine oxidation during apoptosis. Methods Mol Bio. 1105:603-11, 2014. PMID: 2462355

Fazzi F, Njah J, Di Giuseppe M, Winnica DE, Go K, Sala E, St Croix CM, Watkins SC, Tyurin VA, Phinney DG, Fattman CL, Leikauf GD, Kagan VE, Ortiz LA. TNFR1/Phox Interaction and TNFR1 Mitochondrial Translocation Thwart Silica-Induced Pulmonary Fibrosis.  J Immunol. 192(9):3837-46, 2014.  PMID:24623132

Tyurina YY, Poloyac SM, Tyurin VA, Kapralov AA, Jiang J, Anthonymuthu TS, Kapralova VI, Vikulina AS, Jung MY, Epperly MW,Mohammadyani D, Klein-Seetharaman J, Jackson TC, Kochanek PM, Pitt BR, Greenberger JS, Vladimirov VA, Bayir H, Kagan VE.  A mitochondrial pathway for biosynthesis of
lipid mediators. Nat chem. 6(6):542-52, 2014. PMID: 24848241

Shurin MR, Yanamala N, Kisin ER, Tkach AV, Shurin GV, Murray AR, Leonard HD, Reynolds S, Gutkin DW, Star A, Fadeel B, Savolainen K, Kagan VE, Shvedova AA.  Graphene Oxide Attenuates Th2-Type Immune Responses, but Augments Airway Remodeling and Hyperresponsiveness in a Murine Model of Asthma.  ACS Nanop. [Epub ahead of print]. 2014.  PMID: 24847914

Balasubramanian J, Maeda A, Lee JS, Mohammadyani D, Dar HH, Jiang JF, St. Croix CM, S Watkins,  Tyurin VA, Tyurina YY, Klöditz K, Polimova A, Kapralova VI, Xiong Z, Ray P, Klein-Seetharaman J, Mallampalli RK, Bayir H, Fadeel B, Kagan VE.  Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity. Sci. Signal. 8m  ra95,2015.PMID:26396268. http://stke.sciencemag.org/cgi/content/full/sigtrans;8/395/ra95ijkey=o6hms9pYalOro&keytype=ref&siteid=sigtrans



Valerian E Kagan
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