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Stephen R Wisniewski, PhD

Professor, Epidemiology

Vice Provost for Data and Information, Office of the Provost

Co-director, Epidemiology Data Center, Epidemiology

Contact

4420 Bayard Street, Suite 600, Pittsburgh, PA 15260
R-znvy: fgrirjvf@cvgg.rqh
Primary Phone: 967-179-7791
Secondary Phone: 967-179-0763
Fax: 967-179-8220


Personal Statement

My primary research interests include the design and analysis of clinical trials. Specifically, multi-center  clinical trials.  I am currently coordinating multi-center trials of traumatic brain injury, psychiatric disorder, pulmonary disorders and trauma induced coagulopathy.


Education

1994 | University of Pittsburgh, Pittsburgh, PA  | PhD, Epidemiology
1988 | The Ohio State University, Columbus, Ohio | MAS, Statistics
1987 | The Pennsylvania State University, University Park, PA | BS, Mathematics


Teaching

My teaching experience in the Department of Epidemiology has focused on epidemiological methods.  Over the course of my career I have been the primary instructor or a visiting lecturer for both Epidemiology 2180 (Epidemiology Method 1) and Epidemiology 2230 (Epidemiology Methods 2).


Selected Publications

From over 375 peer-reviewed publications

The Endohthalmitis Vitrectomy Study Group. Results of the Endophthalmitis Vitrectomy Study: A Randomized Trial of Immediate Vitrectomy and of Intravenous Antibiotics for the Treatment of Post-Operative Bacterial Endophthalmitis. Archives of Ophthalmology, 1995; 113: 1479-1946.  PMID 9052630

 

The Endophthalmitis Vitrectomy Study Group. The Endophthalmitis Vitrectomy Study: Microbiologic Factors in Visual Outcome. American Journal of Ophthalmology, 122; 833-855: 1996.PMID 8659579

 

Marion DW, Penrod LE, Kelsey SF, Obrist WD, Kochanek PM, Palmer AM, Wisniewski SR and DeKosky ST. Improved Outcome After Traumatic Brain Injury with the Use of Moderate Hypothermia. The New England Journal of Medicine, 336; 540-546; 1997. PMID: 9023090

 

Wisniewski SR, Hammer ME, Grizzard WS, Kelsey SF, Everett D, Packo KH, Yarian DL, Doft BH for the EVS Study Group. An Investigation of the Hospital Charges Related to the Treatment of Endophthalmitis in the Endophthalmitis Vitrectomy Study. Ophthalmology, 1997; 104: 739-745. PMID: 9160017

 

Wisniewski SR, Capone A, Kelsey SF, Groer-Fitzgerald S, Lambert HM, and Doft BH for the Endophthalmitis Vitrectomy Study. The Presenting Characteristics of Postoperative Endophthalmitis in the Endophthalmitis Vitrectomy Study. Ophthamology, 2000;107:1274-1282.PMID 10889097

 

Doft BH, Wisniewski SR, Kelsey SF, Groer-Fitzgerald S for the Endophthalmitis Vitrectomy Study Group. Diabetes and Post-Operative Endophthalmitis in the Endophthalmitis Vitrectomy Study: Implications for Management. Archives of Ophthalmology, 2001;119:650-656. PMID 11346391

 

Lavori PW, Rush AJ, Wisniewski SR, Alpert J, Fava M. Kupfer DJ, Nierenberg A., Quitkin FM, Sacheim HA, Thase ME, Trivedi M for the STAR*D Group. Strengthening Clinical Effectiveness Trials: Equipoise-Stratified Randomization. Biological Psychiatry, 2001-50:792-801. PMID 11720698

 

Wisniewski SR, Belle SH, Coon DW, Marcus SM, Ory MG, Burgio L, Burns R, Schulz R. The Resources of Enhancing Alzheimer’s Caregiver Health (REACH): Project Design and Baseline Characteristics. Psychology and Aging, 2003; 18:375-384. PMID 14518801

 

Sachs GS, Thase ME, Otto MW, Baur M, Miklowitz D, Wisniewski SR, Lavori P, Lebowitz B, Rudorfer M, Frank E, Nierenberg AA, Fava M, Bowden C, Ketter T, Marangell L, Calabrese J, Kupfer D, Rosenbaum for the STEP-BD Investigators. The Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD): A Model for Multisite Collaborative Research and A Bipolar Trial Methodology. Biological Psychiatry, 2003; 53:1028-1042.  PMID 12788248

 

Rush AJ, Fava M, Wisniewski SR, Lavori PW, Trivedi M, Sackeim HA, Thase ME, Nierenberg AA, Quitkin FM, Kashner TM, Kupfer DJ, Rosenbaum JF, Alpert J, Stewart J, McGrath PJ, Biggs MM, Shores-Wilson K, O’Neal BL, Lebowitz BD, Ritz AL, Niederehe G for the STAR*D Investigators Group. Sequenced Treatment Alternatives to Relieve Depression (STAR*D): Rationale and Design. Controlled Clinical Trials, 2004; 25:116-142. PMID 15061154

 

Wisniewski SR, Stegman D, Trivedi M, Husain MM, Eng H, Shores-Wilson K, Luther J, Biggs MM, Burroughs D, Ritz LA, Fava M, Quitkin F, Rush AJ for the STAR*D Investigators. Methods of testing feasibility for sequenced alternatives to relieve depression (STAR*D). Journal of Psychiatric Research, 2004; 38:241-248. PMID 15003429

 

Wisniewski SR, Eng H, Meloro L, Gatt R, Ritz L, Stegman D, Trivedi M, Biggs MM, Friedman E, Shores-Wilson K, Warden D, Bartolowits D, Martin JP and Rush AJ.  Web-based communications and management of a multi-center clinical trial:  the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project.  Clinical Trials, 2004;1:387-398. PMID 16279277

 

Warden D, Rush AJ, Trivedi M, Ritz L, Stegman D, Wisniewski SR.  Quality improvement methods as applied to a multicenter effectiveness trial – STAR*D.  Contemporary Clinical Trials, 2005;26:95-112. PMID 15837455

 

Balasubramani GK, Wisniewski SR, Zhang H, Eng HE.  Development of an efficient SASâ macro to perform permutation tests for two independent samples.  Computer Methods and Programs in Biomedicine, 2005;79:179-187.  PMID 15904990

 

Trivedi MH, Fava M, Wisniewski SR, Thase ME, Quitkin F, Warden D, Ritz L, Nierenberg A, Lebowitz BD, Biggs MM, Luther JF, Shores-Wilson K, Rush AJ for the STAR*D Study Team.  A Comparison of Citalopram Augmentation with Bupropion-SR and Buspirone Following SSRI Failure for Depressed Outpatients: A STAR*D Report.  New England Journal of Medicine, 2006;354:1243-1252.  PMID 16554526.

 

Rush AJ, Trivedi MH, Wisniewski SR, Stewart JW, Nierenberg A, Thase ME, Ritz L, Biggs MM, Warden D, Luther JF, Shores-Wilson K, Niederehe G, Fava M for the STAR*D Team.  A Comparison of Bupropion-SR, Sertraline, and Venlafaxine-XR Following SSRI Failure for Depressed Outpatients: A STAR*D Report.  New England Journal of Medicine, 2006;354:1231-1242.   PMID 16554525 

 

Wisniewski SR, Rush AJ, Balasubramani GK, Trivedi MH, Nierenberg AA for the STAR*D Investigators.  Self-Rated Global Measure of the Frequency, Intensity, and Burden of Side Effects.  Journal of Psychiatric Practice, 2006;12:71-79. PMID 16728903

 

Wisniewski SR, Leon AC, Otto MW, Trivedi MH.  Prevention of Missing Data in Clinical Research Studies.  Biological Psychiatry, 2006;59:997-100.  PMID 16566901

 

Otto MW, Simon NM, Wisniewski, SR, Miklowitz DJ, Kogan J, Reilly-Harrington NA, Frank E, Nierenberg AA, Marangell L, Sagduyu KA, Weiss RD, Miyahara S, Thase ME, Sachs GS, Pollack MH, for STEP-BD Investigators.  One-Year Longitudinal Outcome for Bipolar Patients With Anxiety Disorders: Data from the First 1000 Participants in STEP.   British Journal of Psychiatry, 2006;189:20-25. PMID: 16816301

 

Fava M, Rush AJ, Wisniewski SR, Nierenberg AA, Alpert J, McGrath PJ, Thase ME, Warden D, Biggs MM, Luther JF, Niederehe G, Ritz L, Trivedi MH for the STAR*D Team.  A Comparison of Mirtazapine and Nortriptyline Following Two Consecutive Failed Medication Treatments for Depressed Outpatients: A STAR*D Report.  American Journal of Psychiatry, 2006; 131:1161-1172.  PMID 16816220

 

Wieland ME, Rosenstock J, Kelsey SF, Ganguli M, Wisniewski SR.  Distal Support and Community Living Among Individuals Diagnosed with Schizophrenia and Schizoaffective Disorder.  Psychiatry, 70(1); 1-11.  PMID 17492907 

 

McGrath PJ, Stewart JW, Fava M, Trivedi MH, Wisniewski SR, Nierenberg AA, Thase ME, Davis L, Biggs MM, Shores-Wilson K, Luther JF, Niederehe G, Warden D, Rush AJ for the STAR*D Study Team.  Tranylcypromine Versus Venlafaxine Plus Mirtazapine Following Three Failed Antidepressant Medication Trials for Depression:  A STAR*D Report.  American Journal of Psychiatry, 2006;1531-1541. PMID 16946177

 

Nierenberg AA, Fava M, Trivedi MH, Wisniewski SR, Tahse ME, McGrath PJ, Alpert JE, Warden D, Luther JF, Niederehe G, Lebowitz B, Shores-Wilson K, Rush AJ for the STAR*D Study Team.  A Comparison of Lithium and T3 Augmentation Following Two Failed Medication Treatments for Depression:  A STAR*D Report.  American Journal of Psychiatry, 2006;163:1519-1530.  PMID 16946176

 

Rush AJ, Trivedki MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, Niederehe G, Thase ME, Lavori PW, Lebowitz BD, McGrath PJ, Rosenbaum J, Sackeim HA, Kupfer DJ, Luther J, Fava M.  Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several treatment Steps:  A STAR*D Report.  American Journal of Psychiatry, 2006;163:1905-1917. PMID 17074942

 

Wisniewski SR, Rush AJ, Bryan C, Shelton R, Trivedi MH, Marcus S, Husain MM, Hollon SD, Fava M for the STAR*D Investigators.  Comparison of Quality of Life Measures in a Depressed Population.  The Journal of Nervous and Mental Disease, 2007;195:219-225. PMID 1746881

 

Wisniewski SR, Fava M, Trivedi MH, Thase ME, Warden D, Niederehe G, Friedman ES, Biggs MM, Sackeim HA, Shores-Wilson K, McGrath PJ, Lavori PW, Miyahara S, Rush AJ.  Acceptability of Second-Step Treatments to Depressed Outpatients:  A STAR*D Report.  American Journal of Psychiatry, 2007;164:753-760. PMID 17475734

 

Warden D, Rush AJ, Trivedi MH, Fava M, Wisniewski SR.  The STAR*D project results: A comprehensive review of findings.  Current Psychiatry Reports, 2007;9:449-459. PMID 18221624

 

Cook IA, Balasubramani GK, Eng H, Friedman E, Young EA, Martin J, Nay WT, Ritz L, Rush AJ, Stegman D, Warden D, Trivedi MH, Wisniewski SR.    Electronic source materials in clinical research: Acceptability and validity of symptom self-rating in major depressive disorder.  Journal of Psychiatric Research, 2007;41:737-743. PMID 17275840

 

Miklowitz DJ, Otto MW, Frank E, Reilly-Harrington NA, Kogan JN, Sachs GS, Thase ME, Calabrese JR, Marangell LB, Ostacher MJ, Patel J, Thomas MR, Araga M, Gonzalez JM, Wisniewski SR.   Intensive psychosocial intervention enhances functioning in patients with bipolar depression: Results from a 9-month randomized controlled trial.  American Journal of Psychiatry, 2007;164:1340-1347. PMID 17728418

 

Bryan CJ, Songer TJ, Brooks MM, Thase ME, Gaynes BN, Klinkman M, Rush AJ, Trivedi MH, Fava M, Wisniewski SR.  A comparison of baseline sociodemographic and clinical characteristics between major depressive disorder patients with and without diabetes: A STAR*D report.  Journal of Affective Disorders, 2008;108:113-120. PMID 18037497

 

Advancing Research Standards for PTSD Interventions:  Suggested Approaches for Designing and Evaluating Clinical Trials.

 

Wisniewski SR, Rush AJ, Nierenberg AA, Gaynes BN, Warden D, Luther JF, McGrath PJ, Lavori PW, Thase ME, Fava M, Trivedi MH.  Can Phase III Trial Results of Antidepressant Medications be Generalized to Clinical Practice? A STAR*D Report.  American Journal of Psychiatry, 2009;166;599-607.  PMID 19339358

 

Bryan C, Songer T, Brooks MM, Thase ME, Gaynes B, Klinkman M, Balasubramani GK, Rush AJ, Trivedi MH, Fava M, Wisniewski SRDo Depressed Patients With Diabetes Experience More Side Effects When Treated With CitalopramThan Their Counterparts Without Diabetes? A STAR*D Study.  Primary  Care Companion of the Journal of Clinical Psychiatry, 2009;11(5):186-196. PMID 19956455

 

Kocsis JH, Gelenberg AJ, Rothbaum BO, Klein DN, Trivedi MH, Manber R, Keller MB, Leon AC, Wisniewski SR, Arnow BA, Markowitz JC, Thase ME; REVAMP Investigators.  Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP Trial.  Archives of General Psychiatry, 2009;66(11):1178-88. PMID 19884606

 

Wisniewski SR, Chen CC, Kim E, Kan HJ, Guo Z, Carlson BX, Tran QV, Pikalov A.Global benefit-risk analysis of adjunctive aripiprazole in the treatment of patients with major depressive disorder.  Pharmacoepidemiology and Drug Safety, 2009;18(10):965-72. PMID 19662630

 

Stall R, Duran L, Wisniewski SR, Friedman MS, Marshal MP, McFarland W, Guadamuz TE, Mills TC.  Running in place: implications of HIV incidence estimates among urban men who have sex with men in the United States and other industrialized countries.  AIDS Behavior, 2009;13(4):615-29. PMID 19205867

 

Bryan C, Songer T, Brooks MM, Rush AJ, Thase ME, Gaynes B, Balasubramani GK, Trivedi MH, Fava M, Wisniewski SR.  The impact of diabetes on depression treatment outcomes.  General Hospital Psychiatry, 2010;32:33-41.  PMID  20114126

 

Barkin JL, Wisner KL, Bromberger JT, Beach SR, Wisniewski SRAssessment of functioning in new mothers. Journal of Women's Health, 12010;9:1493-1499. PMID 21054183

 

Williams LM, Rush AJ, Koslow SH, Wisniewski SR, Cooper NJ, Nemeroff CB, Schatzberg AF, Gordon E.International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: Rationale and protocol. Trials, 2011;12. art no. 4 . PMID: 21208417

 

Rush AJ, Trivedi MH, Stewart JW, Nierenberg AA, Fava, M, Warden D, Morris DW, Luther JF, Husain MM, Cook IA, Shelton RC, Lesser IM, Kornstein SG, Wisniewski SR.  Combining Medications to Enhance Depression Outcomes (CO-MED):  Acute and Long-Term Outcomes of a Single-Blind Randomized Study.  American Journal of Psychiatry, 2011; 168:689-701. PMID:  21536692

 

Beers SR, Wisniewski SR, Garcia-Filion P, Tian Y, Hahner T, Berger RP, Bell MJ Adelson PD.  Validity of a pediatric version of the glasgow outcome scale-extended.  Journal of Neurotrauma,  2012;29:1126-1139.  PMID:  22220819

 

Stark JH, Sharma R, Ostroff S, Cummings DAT, Ermentrout B, Stebbins S, Burke DS, Wisniewski SR.  Local spatial and temporal processes of influenza in Pennsylvania, USA:  2003-2009.  PloS ONE,  2012;7:e34245.  PMID:  22470544

 

Stark JH, Cummings DAT, Ermentrout B, Ostroff S, Sharma R, Stebbins S, Burke DS, Wisniewski SRLocal variations in spatial synchrony of influenza epidemics.  PLoS ONE,  2012;7. no. e43528. 

 

Pawun V, Visrutaratna S, Ungchusak K, Mahasing S, Khumtalord C, Tipsriraj S, Chenwittaya C, Guadamuz TE, Wisniewski SR.  Mortality among foreign nationals in chiang mai city, Thailand, 2010 to 2011.  Journal of Travel Medicine, 2012;19:344-351. 

 

Otto MW, Wisniewski SRCBT for treatment resistant depression.  The Lancet, 2013;381:352-353.

 

Adelson PD, Wisniewski SR, Beca J, Brown SD, Bell M, Muizelaar JP, Okada P, Beers SR, Balasubramani GK, Hirtz D. Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial. The Lancet Neurology, 2012;75:6546-553. 

 

Wisner KL, Bogen DL, Sit D, McShea M, Hughes C, Rizzo D, Confer A, Luther J, Eng H, Wisniewski SW. Does fetal exposure to SSRIs or maternal depression impact infant growth?  American Journal of Psychiatry, 2013;170:485-493.

 

Kolko DJ, Campo J, Kilbourne AM, Hart J, Sakolsky D, Wisniewski SR.  Collaborative care outcomes for pediatric behavioral health problems: A cluster randomized trial.  Pediatrics, 2014;133:e981-e982.

Zimmerman RK, Rinaldo CR, Nowalk MP, Balasubramani GK, Moehling KK,
Bullotta A, Eng HF, Raviotta JM, Sax TM, Wisniewski SR.  Viral
infections in outpatients with medically attended acute respiratory illness
during the 2012-2013 influenza season.  BMC Infectious Diseases,
2015;15:art. no. 87.  PMID: 25887948


Bell MJ, Wisniewski SR.  Severe  Traumatic Brain Injury in Children:  A Vision for the Future.  Intensive Care Medicine, 2016;42:1618-20. PMID: 27256038.


Morris A, Fitzpatrick M,Bertolet M, Qin S, Kingsley L, Leo N, Kessinger C, Michael H, Mcmahon D, Weinman R, Stone S, Leader JK, Kleerup E, Huang L, Wisniewski SR.  Use of
rosuvastatin in HIV-associated chronic obstructive pulmonary disease: A randomized pilot study.  AIDS, 2017;31:539-544. 

Stephen R Wisniewski
© 2017 by University of Pittsburgh Graduate School of Public Health

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