Dr. Radosveta P Koldamova, MD, PhD

Professor, Environmental and Occupational Health

Contact

130 De Soto Street, PUBHL, Room 4135, Lab4060.5-4060.10, Pittsburgh 15261
R-znvy: enqnx@cvgg.rqh
Primary Phone: 967-838-2642
Web site:

Assistant(s): 
Lynette Clark, yipynex@cvgg.rqh, 967-179-4255

Personal Statement

Our research is translational neuroscience based primarily on work with animal models of Alzheimer’s disease. For the last 10 years our group has been working with Alzheimer model mice expressing human APOE3 or APOE4 isoforms. We focus on the role of genes associated with Late Onset Alzheimer’s disease such APOE, TREM2, ABCA7 and others. To evaluate functional and morphological changes on cellular, tissue and organism levels we apply wide array of methods such as behavior testing, immunohistochemistry, transcriptomic and lipidomic analysis. Significant time and effort in those projects have been spent on experiments and analysis of massive high throughput sequencing datasets transcription factor binding, histone modifications, as well as expression profiling in brain following exposure and in response to different dietary patterns and environmental toxicants, as well as the application of promising therapeutic agents.


Education

1979 Medical Academy  Sofia, BULGARIA. Medical doctor
1994 Medical Academy & Bulgarian Academy of Sciences, Sofia, BULGARIA, PhD


Teaching


Human genetics: Biochemical and Molecular genetics of complex disease (Epigenetic mechanisms
in human pathology)

 

EOH and Molecular Toxicology Journal Club


Selected Publications

Cody M. Wolfe, Nicholas F. Fitz, Kyong Nyon Nam, Iliya Lefterov, Radosveta Koldamova. The Role of APOE and TREM2 in Alzheimer's Disease - Current Understanding and Perspectives. Int J Mol Sci. 2018 Dec 26;20(1).

Castranio EL, Wolfe CM, Letronne F, Nam KN, Fitz NF, Koldamova R, Lefterov I. ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms. Acta Neuropathol Commun. 2018 Jul 26;6(1):69. doi: 10.1186/s40478-018-0569-2.

Nam KN, Wolfe C, Fitz NF, , Letronne F, Carter AY, Castranio EL, Schug J, Lefterov I, Koldamova R. Integrated approach reveals diet, APOE genotype and gender affect immune
response in APP mice. Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):152-161. doi: 10.1016/j.bbadis.2017.10.018. Epub 2017 Oct 14.

Nam KN, Mounier A, Wolfe C, Fitz NF, Carter AY, Castranio EL, Kamboh HI, Reeves
VL, Wang J, Han X, Schug J, Lefterov I, Koldamova R. Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice. Sci Rep. 2017 Jun 27;7(1):4307. doi: 10.1038/s41598-017-04412-2.

Castranio EL, Mounier A, Wolfe CM, Nam KN, Fitz NF, Letronne F, Schug J, Koldamova R, Lefterov I. Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury. Neurobiol Dis. 2017 Sep;105:1-14. doi: 10.1016/j.nbd.2017.05.006. Epub 2017 May 11.

Carter AY et al. Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice. PLoS One. 2017 Feb 27;12(2):e0172161. doi: 10.1371/journal.pone.0172161. eCollection 2017.

Fitz, N. F., et al. (2017) “Abca1 deficiency affects dendritic density and cognitive function in mice J Alzheimers Dis. 2017;56(3):1075-1085. doi: 10.3233/JAD-161056.

Kyong Nyon Nam, Anais Mounier, Nicholas F. Fitz, Cody Wolfe, Jonathan Schug, Iliya
Lefterov and Radosveta Koldamova. RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomers. Sci Rep. 2016 Apr 7;6:24048. doi: 10.1038/srep24048.

Nicholas F. Fitz, Victor Tapias, Andrea A. Cronican , Emilie Castranio, Muzamil Salem, Alexis Y. Carter, Martina Lefterova,  Iliya Lefterov  & Radosveta Koldamova, Opposing effects of Apoe/Apoa1 double deletion on amyloid β pathology and cognitive performance in APP mice. Brain. 2015 Dec;138(Pt 12):3699-715.

Anais Mounier, Danko Georgiev, Kyong Nyon Nam, Nicholas F. Fitz, Emilie Castranio, Cody Wolfe, Andrea Cronican, Jonathan Schug, Iliya Lefterov and Radosveta Koldamova, Bexarotene activated Retinoid X Receptors regulate neuronal differentiation and dendritic complexity. J Neurosci. 2015 Aug 26;35(34):11862-76. doi: 10.1523/JNEUROSCI.1001-15.2015.

Lefterov, I., Jonathan Schug, Anais Mounier, Kyong Nyon Nam, Nicholas
F. Fitz, and Radosveta Koldamova, Neurobiology of Disease “RNA-sequencing
reveals transcriptional up-regulation of Trem2 in response to bexarotene
treatment”. Neurobiol Dis. 2015 Oct;82:132-140. doi: 10.1016/j.nbd.2015.05.019.

Koldamova R., Fitz FN, Lefterov I, ATP-binding cassette transporter A1: from metabolism to
neurodegeneration. Neurobiol Dis. 2014 Dec;72 Pt A:13-21. doi: 10.1016/j.nbd.2014.05.007.

Nicholas F. Fitz, Emilie L. Castranio, Alexis Y. Carter, Ravindra Kodali, Iliya Lefterov & Radosveta Koldamova: Improvement of memory deficits and Aβ clearance in aged APP23 mice treated with a combination of anti-Aβ antibody and LXR agonist. J Alzheimers Dis. 2014;41(2):535.

Koldamova R, Schug J, Lefterova M, Cronican AA, Fitz NF, Davenport FA, Carter A, Castranio EL, Lefterov I: “Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration”. Neurobiol Dis. 2014 Mar;63:107-14.  

Fitz NF, Cronican AA, Lefterov I, Koldamova R. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science. 2013 May 24;340(6135):924-c.

Radosveta P Koldamova