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Linda L Pearce, PhD

Assistant Professor, Environmental and Occupational Health

Contact

556 Bridgeside , 100 Technology Dr., Pittsburgh, PA 15219
R-znvy: yvc65@cvgg.rqh
Primary Phone: 967-179-8873
Web site:


Personal Statement

 Our research interests center around the response of the mitochondria and hemoglobin to environmental stressors (i.e. cyanide, sulfide and radiation).  EPR (electron paramagnetic
resonance), done in conjunction with Prof. Mike Hendrich at CMU, also provides a useful probe for our investigations.


Education

 University of South Florida, B.S. Clinical Chemistry    
Iowa State University, PhD Inorganic Chemistry



Teaching


Environmental Health Chemistry (EOH 2309)


Selected Publications


Pearce, L. L.; Epperly, M. W.; Greenberger, J. S.; Pitt, B. R.; Peterson, “Identification of
Respiratory Complexes I and III as Mitochondrial Sites of Damage Following
Exposure to Ionizing Radiation and Nitric Oxide.”  J.  Nitric
Oxide, 2001, 5, 128-36.

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J. Kanai, L.L. Pearce, P.R. Clemens, L.A. Birder, M.M. VanBibber, S.-Y. Choi, W.C. deGroat, J. Peterson:  “Identification of a Neuronal Nitric Oxide Synthase in Isolated Cardiac Mitochondria Using Electrochemical Detection”; Proc.
Natl. Acad. Sci. USA, 2001, 98, 14126-14131.

 

 L.L. Pearce, A.J. Kanai, L.A. Birder, B.R. Pitt, J. Peterson:  “The Catabolic Fate of Nitric
Oxide:  The Nitric Oxide Oxidase and Peroxynitrite Reductase Activities of Cytochrome Oxidase”; J. Biol. Chem., 2002, 277, 13556-13562.

 

L.L. Pearce*, E.L. Bominaar, J. Peterson*:  “VisibleRegion MCD and MLD Spectra of Nitrosylferrohemoglobin and Oxyhemoglobin”; Biochem. Biophys. Res. Comm., 2002, 297, 220-223.

 

A. Fago, A.L. Crumbliss, J. Peterson, L.L. Pearce, C. Bonaventura*:  “The Case of the Missing NO-hemoglobin:  Spectral Changes Suggestive of Heme Redox Reactions Reflect Changes in NO-heme Geometry”; Proc. Natl. Acad. Sci. USA 2003, 100, 12087-12092.

 

L.L. Pearce*, E.L. Bominaar, B.C. Hill, J. Peterson*:  “Reversal of Cyanide Inhibition of Cytochrome c Oxidase by the Auxiliary Substrate Nitric Oxide:  An Endogenous Antidote to Cyanide Poisoning?”; J. Biol. Chem. 2003, 278, 52139-52145.

 

A. Kanai*, M. Epperly, L. Pearce, L. Birder, M. Zeidel, S. Meyers, J. Greenberger, W. de
Groat, G. Apodaca, J. Peterson: “Differing Roles of Mitochondrial Nitric Oxide Synthase in
Cardiomyocytes and Urothelial Cells”; Am. J. Physiol. Heart Circ. Physiol.2004, 286, H13-H21.

 
J. Peterson*, A.J. Kanai, L.L. Pearce:  “A Mitochondrial Role for Catabolism of Nitric Oxide in Cardiomyocytes not Involving Oxymyoglobin”; Am. J. Physiol. Heart Circ. Physiol. 2004, 286,
H55-H58.


T. Chen, L.L. Pearce, J. Peterson, D. Stoyanovsky, T.R. Billiar*:  “Glutathione Depletion Renders Rat
Hepatocytes Sensitive to Nitric Oxide-donor Mediated Toxicity”; Hepatology 2005, 42, 598-607.


Pearce, L.L.; Kanai, A.J.; Epperly, M.W.; Peterson, J., “Nitrosative Stress Results in   Irreversible Inhibition of Purified Mitochondrial Complexes I and II without Modification of Cofactors,” Nitric
Oxide 2005 13, 254-263.

 
L. L. Pearce, E. L. Manzano, S. Martinez-Bosch and J. Peterson: “Antagonism of Nitric Oxide Toward the Inhibition of Cytochrome c oxidase by Carbon Monoxide and Cyanide”;Chem. Res.
Toxicol. 21(11), 23073-2081, 2008.


L. L. Pearce, S. Martinez-Bosch, E. L. Manzano, D. E. Winnica, M. W. Epperly and
J. Peterson: “The Resistance of Electron Transport Chain Fe-S Clusters to
Oxidative Damage during the Reaction of Peroxynitrite with Mitochondrial
Complex II and Rat Heart Pericardium”; Nitric Oxide 20 (2009)135-142, doi: 10.1016/j.niox.2008.12.001.

 
M. W. Epperly, J. A. Melendez, X. Zhang, S. Nie, L. L.  Pearce, J. Peterson, D. Franicola, T. Dixon, B. A. Greenberger, P. Komanduri, H. Wong and J. S.Greenberger: “Mitochondrial Targeting of a Catalase Transgene Product by Plasmid Liposomes Increases Radioresistance In Vitro and In Vivo”; Radiation Research (2009) 171, 588-595.

 

Molly Stitt-Fischer, Rachel K. Ungerman, Daniel S. Wilen, Lara M. Huyler, Shannon E.
Raub, Jim Peterson and Linda L. Pearce. “Manganese Superoxide Dismutase is not
Radioprotective in Bovine Pulmonary Artery Endothelial Cells at Systemic Oxygen
Levels”: Radiation Research, (2010) 174, 679–690.

 

Mai Otsuka, Sarah A. Marks, Daniel E. Winnica, Andrew A. Amoscato, Linda L. Pearce and Jim Peterson “Covalent Modifications of Hemoglobin by Nitrite Anion: Formation Kinetics and Properties of Nitrihemoglobin”; Chemical Research in Toxicology. (2010), 23, 1786–1795.


Leah K. Cambal, Megan R. Swanson, Quan Yuan, Andrew C. Weitz, Hui-Hua Li, Bruce R.
Pitt, Linda L. Pearce and Jim Peterson “Acute, Sub-lethal Cyanide Poisoning in Mice is Ameliorated by Nitrite Alone: Complications Arising from Concomitant Administration of Nitrite and
Thiosulfate as an Antidotal Combination”; Chemical Research in Toxicology, (2011) 24, 1104–1112 published in the July issue as a featured article (cover).

Oscar S. Benz, Quan Yuan, Andrew A. Amoscato, Linda L. Pearce, Jim Peterson “Co(III)TMPyP is an Antidote for Acute Cyanide Toxicity” Chemical Research in Toxicology. (2012) 25, 2687–2703.

 
Sang-Min LeeJoseph N. McLaughlin, Daniel R. Frederick1, Lin Zhu, Karla Wasserloos, Iris Kaminski2, Octavia Peck-Palmer, Linda Pearce,  Jim Peterson, CBI Person, Jin; Joseph D. Latoche, Tim D. Oury, Cheryl L. Fattman, Donna Beer-Stolz3, John F. Alcorn4, Derek C. Angus,
Bruce R. Pitt, A. Murat Kaynar   “Metallothionien-induced zincpartitioning exacerbates hyperoxic induced lung injury”, Am J PhysiolLung Cell Mol Physiol March 1, (2013) 304:L350-L360

 
Leah K. Cambal Andrew C. Weitz, Hui-Hua Li, Xi Zheng, Linda L. Pearce and Jim Peterson “Alternative Nitrite Therapies for Acute Cyanide Poisoning in Mice: Complications Arising from Anesthetics” Chemical Research in Toxicology. (2013) May 20;26(5):828-36. PMID:23536974.

 

Angela Fago?§, Alvin L. Crumbliss¶, Michael P.
Hendrich?, Linda L. Pearce**, Jim Peterson**, Robert Henkens§, and Celia Bonaventura§
“Oxygen Binding to Partially Nitrosylated Hemoglobin” Biochimica Biophysica Acta - Proteins and Proteomics Biochimica et Biophysica Acta. (2013) April 25. PMID:23624264.

 
Andrea A. Cronican, Kristin L.  Frawley, Humza Ahmed, Linda L. Pearce* and Jim Peterson* “Antagonism of Acute Sulfide Poisoning in Mice by Nitrite Anion without Methemoglobinemia” in press manuscript (2015) Chemical Research in Toxicology

Linda L Pearce
© 2017 by University of Pittsburgh Graduate School of Public Health

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