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Lawrence A Kingsley, DrPH

Professor, Epidemiology

Professor, Infectious Diseases and Microbiology

Contact

2135 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261
R-znvy: xvatfyrl@cvgg.rqh
Primary Phone: 967-179-0514


Personal Statement

I am an infectious disease epidemiologist with special interest in the natural history of HIV and the metabolic and cardiovascular complications unique to HIV infection and antiretroviral therapies. For the past 30 years, I have served as the Co-Principal Investigator of the Pittsburgh Multicenter AIDS Cohort Study (MACS) and initiated and participated in dozens of internal and external MACS collaborations on a broad array of topics. Early major contributions were the reporting of risk factors for the sexual transmission of HIV (Kingsley, et al. The Lancet 1987), the sexual transmission efficiency of HBV and HIV (Kingsley, et al. JAMA 1990) and the prognostic value of HIV viral load for progression to AIDS and death (Mellors…and Kingsley, Science 1996).  In 1999, I initiated the MACS studies in HIV-associated lipodystrophy and in 2004, I led the first MACS CVD study utilizing cardiac CT for the quantitation of coronary artery calcium, a marker for coronary atherosclerosis.

For over 10 years, I served as Chairman for the MACS Metabolic Working group and have led and participated in several collaborations on investigations of diabetes, insulin resistance, body habitus changes, physical activity and lipid alterations among HIV-infected and uninfected men. Many of these collaborations have produced important contributions to the literature.


Education

1972 | The Pennsylvania State University | Bachelor of Science
1981 | University of Pittsburgh | Master of Public Health
1983 | University of Pittsburgh | Doctor of Public Health


Selected Publications

Kingsley LA, Detels R, Kaslow R, Polk BF, Rinaldo C, Chmiel J, Detre K, Kelsey S, Odaka N, Ostrow D, Van Raden M, Visscher B:  Risk Factors for Seroconversion to Human Immunodeficiency Virus (HIV) Among Male Homosexuals.  The Lancet 1:345-349, 1987.

Kingsley LA, Rinaldo CR, Lyter DW, Valdiserri RO, Belle SH, Ho M: The Sexual Transmission Efficiency of Hepatitis B Virus and Human Immunodeficiency Virus Among Homosexual Men.  JAMA 264:230-234, 1990.

Ragni MV, Kingsley LA: Cumulative Risk for AIDS and Other Outcomes in a Cohort of Hemophiliacs in Western Pennsylvania. J Acq Immun Def Syn  3:708-713, 1990.

Kingsley LA, Zhou SYJ, Bacellar H, Rinaldo CR, Chmiel JS, Detels R, Saah A, VanRaden M, Ho M, and Muñoz A: Temporal Trends in HIV Seroconversion 1984-1989.  A Report From The Multicenter AIDS Cohort Study (MACS). Am J Epid 134:331-339, 1991.

Moore PS, Kingsley LA, Holmberg SD, Spira T, Gupta P, Hoover DR, Parry JP, Conley LJ, Jaffe H, Chang Y: KSHV Infection Precedes Kaposi's Sarcoma: Evidence for Causality.  AIDS 10:175-180, 1996.

Mellors JW, Rinaldo Cr, Gupta P, White RM, Todd JA, Kingsley LA: Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma. Science  272:1167-1170, 1996.

Ragni M, Belle SH, Bass D, Duerstein S, Kingsley LA: Clinical Characteristics and Blood Product Usage in AIDS-Associated Lymphoma in Hemophiliacs: A Case-Control Study.  Haemophilia 4:826-835, 1998.

Riddler SA, Smit E, Cole SR, Li R, Chmiel JS, Dobs A, Palella F, Visscher B, Evans R and Kingsley LA: Impact of HIV Infection and HAART on Serum Lipids in Men.  JAMA  289:2978-2982, 2003.

Palella FJ, Chmiel JS, Riddler SA, Calhoun BC, Dobs A, Visscher BR, Kingsley LA: New Pattern of Lipoaccumulation in HIV-infected Persons With Body Habitus Changes JAMA  296:766-768, 2006.

Kingsley LA, Cuervo J, Munoz A, Palella FJ, Post W, Witt M, Budoff M and Kuller LH. Subclinical Coronary Atherosclerosis, HIV-infection and Antiretroviral Therapy: Results From the Multicenter AIDS Cohort Study.   AIDS  22:1589-1599, 2008.

Longenberger A, Lim Y, Brown TT, Abraham A, Palella FJ Jr, Effros, RB, Orchard TJ, Brooks MM and Kingsley LA:  Low physical function as a risk factor for incident diabetes mellitus and insulin resistance in the Multicenter AIDS Cohort Study:  J Future Virology  6:439-449, 2011.

Post WS, Budoff M, Kingsley L, Palella FJ Jr, Witt MD, Li X, George RT, Brown TT, Jacobson LP. Associations between HIV infection and subclinical coronary atherosclerosis.   Ann Intern Med. 160:458-467, 2014.

Hanna DB, Post WS, Deal JA, Hodis HN, Jacobson LP, Mack WJ, Anastos K, Gange SJ, Landay AL, Lazar JM, Palella FJ, Tien PC, Witt MD, Xue X, Young MA, Kaplan RC, Kingsley LA. HIV Infection Is Associated With Progression of Subclinical Carotid Atherosclerosis. Clin Infect Dis. 2015;61(4):640-50. PMCID: PMC4607734

Kingsley LA, Deal J, Jacobson L, Budoff M, Witt M, Palella F, Calhoun B, Post WS. Incidence and progression of coronary artery calcium (CAC) in HIV-infected and HIV-uninfected men.  AIDS 2015;29(18):2427-34. PMCID: PMC4646724


 

 

Lawrence A Kingsley
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